@Razvan
Manganese is interesting as it's part of the SOD2 enzyme which is particularly needed in case of "dehydration".
Empirically, I've also found it to gave me what (the energy) you described. But I don't believe it stayed that way very long, I don't remember well.
Also, manganese is interesting as it seems to do positive things regarding the AQP4 aquaporin, which is involved in the glymphatic system (cleansing system of the brain).
In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/nitrosative stress (ONS) mediates such swelling. As aquaporin-4 (AQP4) is important in the mechanism of astrocyte swelling, we examined the effect of manganese on AQP4 protein levels in cultured astrocytes. Treatment of cultures with manganese increased AQP4 protein in the plasma membrane (PM), whereas total cellular AQP4 protein and mRNA levels were unchanged, suggesting that increased AQP4 levels is due to its increased stability and/or increased trafficking to the PM and not to its neosynthesis.
Aquaporin-4 in manganese-treated cultured astrocytes
They talk about AQP4 in negative terms here but it really seems to be fundamental for the glymphatic system, for example:
CSF transport is facilitated by the expression of aquaporin-4 (AQP4) water channels on the perivascular endfeet of astrocytes. Mice with genetic deletion of AQP4 (AQP4 KO) exhibit abnormalities in the brain structure and molecular water transport.
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
