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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    MauritioM
    @CrumblingCookie said in Bile can serve as a reservoir for funghi, making them harder to treat: Any new ventures into this? Yes, I'm trying TUDCA atm. It's interesting that some bile acids have pro-microbial effects (primary BAs) and some have anti microbial effects (secondary BAs). https://pubmed.ncbi.nlm.nih.gov/39204302/ TCA for example enables fungal infections. "...TCA through drinking water is sufficient to induce colonization and dissemination of CA in wild-type and immunosuppressed mice." https://pmc.ncbi.nlm.nih.gov/articles/PMC8708873/ While LCA and DCA have anti-fungal effects in a variety of ways. (TUDCA should have a similar effect) "Interestingly, LCA and DCA also significantly inhibited the germ tube, hyphae and biofilm formation in C. albicans. " https://pubmed.ncbi.nlm.nih.gov/29648597/ The main reason for taking tudca is to thin the bile and support the liver - gallbladder axis. That seems to be the bottleneck for me. Maybe working on the affected organs is more fruitful than trying to eradicate the fungus? Not sure. And since TUDCA should have significant direct anti-fungal effects on top of that, it could be suitable candidate in my case.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    H
    @jakethesnake you can read about BPC-157 here Judging by the thread so far, the last thing I'd suggest before trying Accutane is maybe some antibiotic if you haven't already - a lot of stuff on here about that.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    393 Topics
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    hwisdomH
    @jamezb46 said in Fenclonine: @hwisdom It doesn't block serotonin but it increases dopamine and as Georgi has written many times whenever dopamine increases serotonin tends to decrease because of enzyme competition. There are exceptions but in general the above is true as a rule. ok thought so, thought it was smth like metergoline
  • Recipes, food, meal prep, brands. Discuss them all here.

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    JenniferJ
    @Mossy, no worries. I don’t feel burdened by the thread. You just seem more skilled than I am. I can see the efficiency of being precise, for sure. I’m a recovering perfectionist and highly analytical so I understand that, as well. At its worst, I suffered from analysis paralysis so I took a much needed information vacation to reconnect to my instincts and intuition. I suspect men are naturally more instinctual than analytical, but Western culture creates self-doubt by valuing external authority over instinct. Thank you. Yes, absolutely, supporting the matter can help the mind. Maybe not the most popular opinion, but I think mind over matter can be dangerous. I don’t think we should give all our power away to our biology, but I do think we should give ourselves grace. Even though we’re capable beings, sometimes we need more than willpower and positive thinking to overcome our challenges. There’s no shame in receiving help. That’s a reasonable reaction. There’s nothing like the wrong colored cup to ruin a drink. I like that—“touch water.” Not sure if you’ve heard of it before, but there’s actually such a thing as float therapy. It’s sensory deprivation and involves floating in a tank filled with salt water. It’s like the Dead Sea encapsulated. I could never do it as I’m claustrophobic but aside from the enclosed tank, it seems very relaxing. Having premade ingredients is smart. I have a few sides and meats I keep in the fridge to mix and match throughout the week like roasted honey butter carrots, mashed and scalloped potatoes, marinated pork tenderloin and herbed turkey tenderloin, and then some buns I keep in the freezer that take only 25 seconds in the microwave to heat up. My dad’s appetite is so low that no food appeals to him. It’s a side-effect of his cancer treatments that was made worse by the flu and his stubbornness. Despite my warnings, he didn’t get the gravity of the treatments and kept up his normal routine. He’s a musician and continued playing gigs through the worst of his symptoms, caught colds, shared them with me, and we were at the tail end of one when we got the flu at Christmas. A month in and we still felt off, but he played another gig, said he felt so bad that he had to lean against the wall while playing, is now feeling so lousy he can’t walk more than a yard without asking to be put down, while I fantasize about living like a homeless person on the beach, floating around all day on a surfboard and eating Cantonese takeout because anything more than that seems exhausting. Haha! Thankfully, my useless knowledge is not limited to health so I’m ready for any gameshow. But you’re right, Wonka anything is better because it’s mixed with love, sprinkled with dew, covered in chocolate and a miracle or two. Lord knows I could use a miracle or two, and a maid, and a cook, and something for the delirium that’s clearly setting in. Help me!
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @sunsunsun XD
  • Suppression of Haidut's Cancer Cure

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    ChudC
    @the-MOUSE you dont really need hair once your his age and already have wife/kids. and being built like that is peaty. also 1.5 liters chocolate ice cream/day diet cures hairloss but you need to supp bicarb, sunbathe, and do nofap for it to take effect.
  • Taking zinc/copper/selenium and iodine for thyroid

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  • Rate the Supplement Stack of a Canadian Peater

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    PrinceTrebataP
    @Nomanarch A large amount of peaters I meet online either here or on the RPF are from Canada including me. It's interesting because I would think for our size it would be much rarer to see a Canadians on here. To answer your question though all the substances you use are good and peaty but it can be excessive if your taking them everyday. t3 and t4 are easily acquired via meds.com.mx. I had no problems getting mine through customs. Besides that ensuring you have adequate carb intake, salt to taste, eating gelatinous foods. Some other supplements you can think about trying in the future are Progest e, Pregnenolone, and Cyproheptadine.
  • Protein synthesis / net carbs

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    Purp1eOneP
    @Jennifer said in Protein synthesis / net carbs: “*Protein: (about 15-20% calories) .6-.8g/lb. Protein should be on the higher end if you are active, or you are older. Protein sources should be from ruminant meat (beef, bison, lamb, goat), specific seafood (shrimp, scallops, cod, sole, oysters, mussels, clams), pasture raised eggs, very lean 99% chicken/ turkey/ fowl (These are very lean because they are high in polyunsaturated fats if not).” I am older and active to I try to get 1g/lb. Like I mentioned in an earlier post when I dropped the protein intake below that my recovery suffered but that was with lower carbs so now that I am increasing them I will adjust and see how it works. I only track animal based protein in crono and disregard the plant based. @Jennifer said in Protein synthesis / net carbs: Since you developed allergies and digestive issues following a keto(ish) elimination diet and feel better since upping your carbs, I wonder if your thyroid was affected. Have you tracked your temps and pulse rate first thing in the morning and 20–30 minutes after eating? Too much protein relative to your needs and not enough carbs can lower thyroid function, and poor thyroid function is a common cause of allergies. I never had any thyroid problems until I did the lower carb diet. I did lab work while I was on that diet and my free T3 crashed but as soon as I increased the carbs it came right back to upper levels and that was just around 120 carbs. Definitely affected my thyroid. Unfortunately I had food allergies before starting that diet. I have had to avoid shell fish for quite some time now. But the EoE and possibly related to dairy/eggs could be the supps she has me on or my gut is now so messed up that will be need to be corrected. Would be nice if it was one of the supplements. Good thing is I am rotating off of some of the supps she has had me on for a year now and that is in the time frame EoE appeared. Something I will need to watch, thanks.
  • oxidised fish oil experiment

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    Milk DestroyerM
    @the-MOUSE That does seem to be what a couple of people that did hardcore Peating are saying. I can't say whether it is or not as the only time I was supplementing with lots of omega-3 was when I was also on a shit diet and the omega-3 didn't seem to help the shit diet.
  • 0 Votes
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    DavidPSD
    The Multifaceted Roles of Proline in Cell Behavior Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer.
  • This topic is deleted!

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  • Best Soda?

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    Ray Van WinkleR
    Wallmart has jarritos now, i get it delivered every week
  • Does t3 reduce facial bloating?

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    B
    @PrinceTrebata This morning I was 97.1 with 60 pulse. I tend to wake up a bit puffy, feet kinda swole feeling, face lacking color like not much circulation, bit stuffy nosed. I was 99.2 the evening before this. After eating and little walk I get my metabolism and temps back up to a good level and feel good. I’ve been over the adrenaline hump since ramping up to this dose over the past few months taking it slow this time. I’ve never done any blood tests but I take vitamin D daily
  • Struggling on the Ray Peat Diet?

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    P
    I couldn't do average grocery store orange juice from unripe oranges. I don't tolerate oranges well in general. No problem with sugar and milk though. The ideal Ray Peat diet is cherimoyas and gelatin, lobster and Italian cheese as he said in the back of a tiger interview. Milk and orange juice are least bad while economical. Orange juice instead of whole oranges cause Ray had an allergy to orange fiber.
  • Slight pain when supplementing TUDCA

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    PrinceTrebataP
    @irs I don't know how effective TUDCA really is. I know low ratio of t4/t3 around 1/1 2/1 is good for the liver and would help your hypothyroidism. Coffee is generally recommend by peat as well. Fatty liver is a pretty serious issue and while TUDCA may help I don't think it will solve it.
  • Potatoes causing skin issues

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  • How to get rid of dark circles?

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    cs3000C
    @Cezar4911 its often showing hypoxia or leaky vessels (low oxygen tissue, skin around the eyes is thin so shows it clearly). u can see this at peoples finger tips / toes / tip of nose / lips in people with poor circulation, Cyanosis https://upload.wikimedia.org/wikipedia/commons/thumb/d/dc/Cynosis.JPG/1024px-Cynosis.JPG , milder version of this common sign of hypothyroidism (can be iron deficiency, sleep apnea, poor lung heart function etc stuff that effects bloodflow rbc bodyheat). ray said he noticed this going away when people fixed hypothyroidism
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  • Healing ups and downs - PEM query

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    J
    @LucH thank you for that. I have also been taking low dose b- complex, but it prob doesn't have enough b2. I find supplementing the b vitamins to be so complex, with so many pitfalls. You need x to make y work, but if you take too much x, it will deplete z etc etc. It's an endless minefield. I'm going to just work on thyroid and diet, and try and get enough b vitamins from milk and liver. Even if I don't fix all my issues, I should still make real progress.
  • Beef gelatin

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    yerragY
    @Cezar4911 I can buy beef tendons that have been well processed such that it is all white and transparent. It steams well into a clear gelatin that can also be used as jello. Costs me $7/kg wet and assuming 75% moisture, translates to $28/kg dry. I consume this in 2 months. Beef tendons are best IMHO because it is free from any endotoxins. Buying gelatin is fraught with uncertainty as to sourcing, as you have to trust the word of the processor/manufacturer. And you can trust no one you don't know.
  • How much butter do you put in potatoes?

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    JenniferJ
    @Cezar4911, I usually put roughly 2 tablespoons of butter per kilo of potatoes.
  • Trynna cop som halal Armour (NDT)

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    Milk DestroyerM
    In Sweden, I don't think you'll find a bovine variation of an Armour alternative at all, unfortunately. Bovine thyroid glandular supplement is probably obtainable there but the quality is dubious and you have no idea what ratio of t4:t3 you'd be getting. Might be worth pinning more of your thoughts on diet and lifestyle/environment rather than spending a lot of money on rare imported thyroid drugs.
  • Secondary Hypogonadism

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    KvirionK
    @mavuue If your cortisol is elevated (probably is) it would be helpful to lower it too (together with estrogen). https://testonation.com/2019/06/09/43-ways-to-lower-cortisol-that-work/ In general, the best approach is to focus on improving your overall health, especially metabolism with thyroid optimization (as others already mentioned). https://www.youtube.com/watch?v=-FTOVRcUqTs Stay away from reductionistic desperate steps like partially estrogenic Clomid or inconvenient HCG...
  • thoguhts this vid

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    the MOUSET
    @BroJonas jfl