Coca leaves
traditionally been used for altitude sickness (MoA= increase in CO2?),
Increasing stamina and reducing hunger and fatigue
Cocaine is just one of the many bioactive molecules. It contains 14 alkaloids in total .
They probably have synergistic effects.
The biological activity of the following alkaloids has been reported in the literature: cocaine, cinnamoylcocaine, benzoylecgonine, methylecgonine, pseudotropine, benzoyltropine, tropacocaine, alpha- and beta-truxilline, hygrine, cuscohygrine and nicotine.
https://pubmed.ncbi.nlm.nih.gov/6379304/
Ray said that the issue with cocaine is that increases your metabolism so much that you quickly develope vitamin deficiencies. This study found that chewing coca leaves increases the metabolisms of subjects by up 66%. There was one guy in the study for who it reduced it metabolism by about 20% and it was also the guy with the lowest body temp. Coca leaves actually decreased his temp from 36.3 to 36°C. So it seems like it made him hypoglycemic,maybe he didn't eat beforehand ?For another guy it increased his temps to 37.6 .
Interesting read:
http://www.scielo.org.pe/scielo.php?pid=S1726-46341944000400003&script=sci_arttext&tlng=en
Man cured his arthritis and impotence with coca.
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