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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    645 Topics
    4k Posts
    C
    @sunsunsun Wax moths? They don't even have neutrophils and I won't deep-dive into finding out how their hemolymphs specifically compare to human or mammalian neutrophils. I really do harbor strong apprehensions against the potential (mis)use of doxy on fungal infections. What I would much rather do is oral terbinafin + fluconazole. The terbinafin by itself is useless against many fungi species but allegedly it strongly inhibits expression of the fungal efflux pumps responsible for azole resistance! This still won't tackle activitiy in the biliary tract, though. I've done some more reading of publications on biliary / gallbladder candida / fungi. Fungi can be causes of calculous (lithiasic) or also acalculous cholecystitis with or without mixed bacterial infections (Escherichia coli, Enterococcus, Klebsiella, Enterobacter, Clostridia). Even in such rare and often fatal cases that happened to be documented, candidemia was rare despite frequent (almost always) fungal infection of other organs. https://pubmed.ncbi.nlm.nih.gov/8862389/ https://pubmed.ncbi.nlm.nih.gov/28703118/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8764969/ https://pmc.ncbi.nlm.nih.gov/articles/PMC12338181/ https://pubmed.ncbi.nlm.nih.gov/24474028/ https://pubmed.ncbi.nlm.nih.gov/8207288/ I don't have visible gallbladder wall thickening or distention or an obviously, universally accepted liver disease (except for hepatomegaly) but if I had I sure as hell would want to insist on flucytosine, or flucytosine + i.v amphotericin B along with any broad-spectrum antibiotics and before mutilating surgeries they'd offer. Have looked more into berberine again, too. It's impossible to achieve its antimicrobial concentrations (at least 0.1mg/mL) systemically. Serum concentrations are about 0.5 - 16 ng/mL. I.e. 0.000005 mg/mL. Ridiculous! The berberine in practical doses of 500-1500mg will thus be acting mainly within the GI lumen in support of oral Ampho-B. Berberine has low absorption but some will spill over to reach the liver for extensive first-pass metabolism, yet probably not into biliary ducts.

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    702 Posts
    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    lobotomizeL
    @DavidPS said in The Top 5 Can’t-Miss Sport Supplements: Nitrates, found in beetroot juice Nitrates, found in beetroot juice. they interfere with cytochrome c oxidase no?

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    390 Topics
    4k Posts
    daposeD
    @lobotomize right but this is a mycelium product not a mushroom (fruiting of mycelium) product. I know Reishi mushroom blocks 5 ar but I don’t see that shiitake does. Thanks, I’ll keep looking!

  • Recipes, food, meal prep, brands. Discuss them all here.

    236 Topics
    2k Posts
    LucHL
    @Mossy said in The processing of MILK and unsaturation: I don't worry about it. I consider what would be best, and I do all that I can, and then let it go. Well done, I agree. If you use a plastic bottle for carrying water, it shouldn't be a problem (short time). Of course no stagnation from the preceding amount (dry). No bacteria.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    89 Topics
    1k Posts
    LukeL
    @engineer I can't use the entire weight because I somehow lost some of the sand bags (probably while I was moving, a former colleague once said "Moving three times is like being burglarized once"). The max weight is about 20kg now, That weight is good for exercises like pushups or body rows where you make quick progress and can carry more added weight. The vest I have is also pretty tight, so it doesn't bother me much with pushups. It's also good for weighted jump squats. I don't have a pullup bar right now, but I don't think I could ever reach multiple pullups with 20/25kg added weight. I could hardly do eight pullups without vest even when I was still young and in good shape. It's definitely a great addition.
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  • ?

    How to get rid of dark circles?

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    cs3000C
    @Cezar4911 its often showing hypoxia or leaky vessels (low oxygen tissue, skin around the eyes is thin so shows it clearly). u can see this at peoples finger tips / toes / tip of nose / lips in people with poor circulation, Cyanosis https://upload.wikimedia.org/wikipedia/commons/thumb/d/dc/Cynosis.JPG/1024px-Cynosis.JPG , milder version of this common sign of hypothyroidism (can be iron deficiency, sleep apnea, poor lung heart function etc stuff that effects bloodflow rbc bodyheat). ray said he noticed this going away when people fixed hypothyroidism
  • ?

    This topic is deleted!

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  • J

    Healing ups and downs - PEM query

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    J
    @LucH thank you for that. I have also been taking low dose b- complex, but it prob doesn't have enough b2. I find supplementing the b vitamins to be so complex, with so many pitfalls. You need x to make y work, but if you take too much x, it will deplete z etc etc. It's an endless minefield. I'm going to just work on thyroid and diet, and try and get enough b vitamins from milk and liver. Even if I don't fix all my issues, I should still make real progress.
  • ?

    Beef gelatin

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    yerragY
    @Cezar4911 I can buy beef tendons that have been well processed such that it is all white and transparent. It steams well into a clear gelatin that can also be used as jello. Costs me $7/kg wet and assuming 75% moisture, translates to $28/kg dry. I consume this in 2 months. Beef tendons are best IMHO because it is free from any endotoxins. Buying gelatin is fraught with uncertainty as to sourcing, as you have to trust the word of the processor/manufacturer. And you can trust no one you don't know.
  • ?

    How much butter do you put in potatoes?

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    JenniferJ
    @Cezar4911, I usually put roughly 2 tablespoons of butter per kilo of potatoes.
  • hwisdomH

    Trynna cop som halal Armour (NDT)

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    Milk DestroyerM
    In Sweden, I don't think you'll find a bovine variation of an Armour alternative at all, unfortunately. Bovine thyroid glandular supplement is probably obtainable there but the quality is dubious and you have no idea what ratio of t4:t3 you'd be getting. Might be worth pinning more of your thoughts on diet and lifestyle/environment rather than spending a lot of money on rare imported thyroid drugs.
  • M

    Secondary Hypogonadism

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    KvirionK
    @mavuue If your cortisol is elevated (probably is) it would be helpful to lower it too (together with estrogen). https://testonation.com/2019/06/09/43-ways-to-lower-cortisol-that-work/ In general, the best approach is to focus on improving your overall health, especially metabolism with thyroid optimization (as others already mentioned). https://www.youtube.com/watch?v=-FTOVRcUqTs Stay away from reductionistic desperate steps like partially estrogenic Clomid or inconvenient HCG...
  • the MOUSET

    thoguhts this vid

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    the MOUSET
    @BroJonas jfl
  • PeatPerspectiveP

    Oyster alternative? Fish and Shellfish Allergy

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  • lulueatsmeatL

    I have hit rock bottom please help.

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    Hando-JinH
    Thyroid.
  • NNightN

    Low salt diet and water restriction

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    NNightN
    @Razvan Manganese is interesting as it's part of the SOD2 enzyme which is particularly needed in case of "dehydration". Empirically, I've also found it to gave me what (the energy) you described. But I don't believe it stayed that way very long, I don't remember well. Also, manganese is interesting as it seems to do positive things regarding the AQP4 aquaporin, which is involved in the glymphatic system (cleansing system of the brain). In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/nitrosative stress (ONS) mediates such swelling. As aquaporin-4 (AQP4) is important in the mechanism of astrocyte swelling, we examined the effect of manganese on AQP4 protein levels in cultured astrocytes. Treatment of cultures with manganese increased AQP4 protein in the plasma membrane (PM), whereas total cellular AQP4 protein and mRNA levels were unchanged, suggesting that increased AQP4 levels is due to its increased stability and/or increased trafficking to the PM and not to its neosynthesis. Aquaporin-4 in manganese-treated cultured astrocytes They talk about AQP4 in negative terms here but it really seems to be fundamental for the glymphatic system, for example: CSF transport is facilitated by the expression of aquaporin-4 (AQP4) water channels on the perivascular endfeet of astrocytes. Mice with genetic deletion of AQP4 (AQP4 KO) exhibit abnormalities in the brain structure and molecular water transport. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
  • U

    PUFA & weight loss

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    U
    @LucH thank you for the "in depth" reply.
  • HarlockH

    Danny Roddy on "avoid liquid thyroid"

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    secondkelpingS
    @Harlock hmmm, I feel like there is a large difference between people who are on the skinny hypothyroid side versus the fat hypothyroid side. I'm on the fat side and had to up my dose of thyroid by several times to feel anything. I have used tyronene, tyromix, and tyromax. Tyromax was really the only one that needs to be shaken thoroughly to be sure of the dose, but even then, I've taken high thyroid doses through Forefront NDT both the 130mg and the 65mg (65mg is what I take now). I feel like thyroid can certainly be dangerous, but we're talking about 2 different types of hypothyroidism sometimes. Maybe people who need super specific doses of thyroid are different than those like me who can down 130 mg of T3/T4 mix about 1:4-ish. Then lower to 65 mg with the same ratio with minimal change in effect... Idk, I understand Danny wants to stay true to RP, but I'm into Bulgarian dark peating lol.
  • the MOUSET

    countertop reverse osmosis filter

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    jhpJ
    @RealNeat Do you know where I would be able to get a aquanui or similar filter in the UK?
  • PrinceTrebataP

    Increasing DHT

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    E
    @Crypt-Keeper What I meant by 100ml was to ease the equation, so if you want a 5% solution with 5g dht, you would need 100ml dmso, but if you want a 5% solution with 2.5g dht, you need 50ml dmso. About the moisturizer, good point, but dmso itself is very liquidy so some gel like substance like pure aloe vera could make application easier. Totally not needed though. So if you dissolved 5grams of dht into 100ml dmso, the concentration would be 5%, and if you applied 1ml of that solution, you would get 50mg dht. PS: The prior post talks about milligrams instead of grams so mb.
  • rtR

    What do you all think about Goatis aka Sv3rige?

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    thyroidchor27T
    @EustaceBagge said in What do you all think about Goatis aka Sv3rige?: I agree with you, he looks very calm and has nice skin that is not just superficially good looking but has a great quality to it. [image: YxeQeT.gif]
  • L

    "Glucose Loading" protocol, a la Dr Stephens - A Critique

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    J
    @LetTheRedeemed said in "Glucose Loading" protocol, a la Dr Stephens - A Critique: @Janelle525 yes. I’m definitely at the pinnacle of my salt intake, haha. I lowered my sugar consumption, or at least balanced it with spreading out my protein intake, and the headaches went away. That was a while ago. And I definitely still consume quite a bit of sugar: several sodas/juice/sweat teas per day, plus spoonfuls of honey with milk, and ice cream. I’ve definitely found my max sugar capacity Haha okay!
  • PrinceTrebataP

    Transdermal Application Poll

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    Crypt KeeperC
    I'm going to not vote because I haven't felt an effect from anything I've put anywhere transdermally yet. Although I've only tried arms, tops of feet, stomach and navel.
  • W

    threonine/serine - can this substitute glycine?

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  • the MOUSET

    got palpiatations eating butter

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    F
    Are you sure it is the heart? I think it could be the gallbladder secreting more bile acid to digest the butter, sometimes it happens to me after a fat heavy meal.