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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    656 Topics
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    alfredoolivasA
    Prolactin group had much lower estradiol, but the before measurements were not taken https://clinicaltrials.gov/study/NCT00438490?tab=results#results-overview [image: 1776025415588-b9b35925-d2d6-4a82-a21a-5d10cb1f8980-image-resized.png] https://pmc.ncbi.nlm.nih.gov/articles/PMC1950489/#sec10 Prolactin group had constantly lower estradiol [image: 1776025690063-22a17dd3-15b4-45d4-8ddb-9b4ce200582d-image.png] Prolactin group ate less [image: 1776025731300-00c2a08c-5c05-4b81-b71b-c7ad188be488-image.png] [image: 1776025781492-02534d1d-c047-4b11-98ad-7bad30f2cedf-image.png] "Short-term prolactin administration causes expressible galactorrhea but does not affect bone turnover:"
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    LucHL
    @GRay said in mk4 dosing?: isn't only the k1 that effect clotting? K1 and K2MK7 too affect clotting. For Chris Masterjohn, MK7 would even be better. Chris Masterjohn : « The ultimate vitamin K2 resource »). https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/ Excerpt 1: There is reason to think MK-7 would be better at supporting blood clotting. “MK-7 is not just three times better than K1 at reaching bone; it’s also five times better at supporting blood clotting (Schurgers, 2007). This may be because the greater fat-solubility of MK-7 makes it hold on more tightly to the membranes within liver cells, making it stay active in the liver much longer rather than being released and broken down (Shearer, 2008). The liver is where clotting proteins are made, so more extended activity in the liver would explain why MK-7 could better support blood clotting. If this is correct, other long-chain MKs such as MK-8 and MK-9 probably share this property as well.” Additional comment: The risk of improper clot formation is increased in cases of low vitamin K levels. Vitamin K (VK) does not cause or dissolve blood clots. However, VK enhances the function of both these systems. VK1 can therefore be seen as a facilitator: Procoagulant factors are VK-dependent. Remind that platelet formation requires 10-12 days after taking aspirin, whatever the dose is (baby or adult caps).
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    CiceroC
    @engineer 5ar Society tweeted about developing new products, and even mentioned Peat and Haidut in a tweet. I wonder if we could convince them to make a transdermal. They're so expensive but I'd be willing to pay for that.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer Ok, so indeed, truly finger food.  That phrase passed right over my head first reading it.  Makes sense now, what you made.  Pancakes I have been thinking about, and that will probably be sometime soon for my dad and I. No worries, you didn't scare me off of thyroid, my body did.  Somewhere along the line, my body became hyper-sensitive, and everything makes me feel off.  Though, I have a long list, and large collection, of supplements I'm going to try again.  Next up is CoQ10.  After not being able to take the tea you recommended, due to side effects, I'm looking for something else for gum health.  I'm still going to try the tea again, but as a rinse.  And I do agree, some stress is good.  There no doubt is truth to the adage that we should do things that challenge us.  Most of my challenges are the unadventurous kind these days, but even so, challenges still. Surfing is hard, at at least it was for me. Though, there is nothing quite like it. I have friends who surf, but I've never taken to it.  I'm decent at sports, in general, but water, strangely, changes things for me.  These days, though, not a lot of outdoor stuff, a part from yard work.  I do have a friend wanting to go mountain hiking, which is another item on my to-do list. Well, maybe I have that wrong then, at 5,000 year.  Maybe it is a shorter time frame.  Funny about the turkey.  I used to have similar experiences as a child, picking up raw milk and eggs from the local farms, and seeing the peacocks strutting their stuff.  Male birds really do think they are rock stars...very funny. Yeah, I really like cinnamon as well.  I just made cinnamon buns for my dad and I, and doubled the cinnamon from the recipe.  Every time I make something like that, I say I won't be doing this again...haha.  That is more complicated than the cinnamon raisin bread.  I couldn't understand the rolling process, strictly by the written recipe, and I started to have something that looks like a sci-fi, cocooned creature.  I know it's not rocket science, but I was attempting to follow the recipe to a tee.  I'm one of those strange males that likes to follow instructions...sometimes .  And, to justify myself a little bit, I went online, to see the same recipe, and they've corrected many of the instructions.  They originally said the I should lay the dough out in a 6" x 13" rectangle, and it should've been 16" x 12"!  And they reduced their cooking time by 15 minutes...no wonder the buns were over cooked. I definitely prefer sprouted, so thanks for sharing that.  The only thing I have sprouted currently is oatmeal, because I can get it at a good price.  As well, I couldn't find sprouted and heritage together.  Do you have an opinion of which would be preferred out of those two: modern wheat but sprouted, or heritage but not sprouted?  My thought is the latter would be preferred, as the claim is that heritage or older wheat is more digestible, along with better nutritional value from modern wheat.  Also, there is the glyphosate factor.  I actually really like the taste of millet, though my only experience with it is as a side with a meal.  I stopped eating it, along with most grains, about 9 years ago.  So maybe I'll look into that again.  I still do try to limit my grains, apart from bread.  I tend to eat potatoes, not grains, with meals.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    M
    I think keto DHT has more of a stabilizing effect on personality/mood compared to andro.
  • oxidised fish oil experiment

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    Milk DestroyerM
    @the-MOUSE That does seem to be what a couple of people that did hardcore Peating are saying. I can't say whether it is or not as the only time I was supplementing with lots of omega-3 was when I was also on a shit diet and the omega-3 didn't seem to help the shit diet.
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    DavidPSD
    The Multifaceted Roles of Proline in Cell Behavior Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer.
  • This topic is deleted!

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  • Best Soda?

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    Ray Van WinkleR
    Wallmart has jarritos now, i get it delivered every week
  • Does t3 reduce facial bloating?

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    B
    @PrinceTrebata This morning I was 97.1 with 60 pulse. I tend to wake up a bit puffy, feet kinda swole feeling, face lacking color like not much circulation, bit stuffy nosed. I was 99.2 the evening before this. After eating and little walk I get my metabolism and temps back up to a good level and feel good. I’ve been over the adrenaline hump since ramping up to this dose over the past few months taking it slow this time. I’ve never done any blood tests but I take vitamin D daily
  • Struggling on the Ray Peat Diet?

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    P
    I couldn't do average grocery store orange juice from unripe oranges. I don't tolerate oranges well in general. No problem with sugar and milk though. The ideal Ray Peat diet is cherimoyas and gelatin, lobster and Italian cheese as he said in the back of a tiger interview. Milk and orange juice are least bad while economical. Orange juice instead of whole oranges cause Ray had an allergy to orange fiber.
  • Slight pain when supplementing TUDCA

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    PrinceTrebataP
    @irs I don't know how effective TUDCA really is. I know low ratio of t4/t3 around 1/1 2/1 is good for the liver and would help your hypothyroidism. Coffee is generally recommend by peat as well. Fatty liver is a pretty serious issue and while TUDCA may help I don't think it will solve it.
  • Potatoes causing skin issues

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  • How to get rid of dark circles?

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    cs3000C
    @Cezar4911 its often showing hypoxia or leaky vessels (low oxygen tissue, skin around the eyes is thin so shows it clearly). u can see this at peoples finger tips / toes / tip of nose / lips in people with poor circulation, Cyanosis https://upload.wikimedia.org/wikipedia/commons/thumb/d/dc/Cynosis.JPG/1024px-Cynosis.JPG , milder version of this common sign of hypothyroidism (can be iron deficiency, sleep apnea, poor lung heart function etc stuff that effects bloodflow rbc bodyheat). ray said he noticed this going away when people fixed hypothyroidism
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  • Healing ups and downs - PEM query

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    J
    @LucH thank you for that. I have also been taking low dose b- complex, but it prob doesn't have enough b2. I find supplementing the b vitamins to be so complex, with so many pitfalls. You need x to make y work, but if you take too much x, it will deplete z etc etc. It's an endless minefield. I'm going to just work on thyroid and diet, and try and get enough b vitamins from milk and liver. Even if I don't fix all my issues, I should still make real progress.
  • Beef gelatin

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    yerragY
    @Cezar4911 I can buy beef tendons that have been well processed such that it is all white and transparent. It steams well into a clear gelatin that can also be used as jello. Costs me $7/kg wet and assuming 75% moisture, translates to $28/kg dry. I consume this in 2 months. Beef tendons are best IMHO because it is free from any endotoxins. Buying gelatin is fraught with uncertainty as to sourcing, as you have to trust the word of the processor/manufacturer. And you can trust no one you don't know.
  • How much butter do you put in potatoes?

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    JenniferJ
    @Cezar4911, I usually put roughly 2 tablespoons of butter per kilo of potatoes.
  • Trynna cop som halal Armour (NDT)

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    Milk DestroyerM
    In Sweden, I don't think you'll find a bovine variation of an Armour alternative at all, unfortunately. Bovine thyroid glandular supplement is probably obtainable there but the quality is dubious and you have no idea what ratio of t4:t3 you'd be getting. Might be worth pinning more of your thoughts on diet and lifestyle/environment rather than spending a lot of money on rare imported thyroid drugs.
  • Secondary Hypogonadism

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    KvirionK
    @mavuue If your cortisol is elevated (probably is) it would be helpful to lower it too (together with estrogen). https://testonation.com/2019/06/09/43-ways-to-lower-cortisol-that-work/ In general, the best approach is to focus on improving your overall health, especially metabolism with thyroid optimization (as others already mentioned). https://www.youtube.com/watch?v=-FTOVRcUqTs Stay away from reductionistic desperate steps like partially estrogenic Clomid or inconvenient HCG...
  • thoguhts this vid

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    the MOUSET
    @BroJonas jfl
  • Oyster alternative? Fish and Shellfish Allergy

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  • I have hit rock bottom please help.

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    Hando-JinH
    Thyroid.
  • Low salt diet and water restriction

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    NNightN
    @Razvan Manganese is interesting as it's part of the SOD2 enzyme which is particularly needed in case of "dehydration". Empirically, I've also found it to gave me what (the energy) you described. But I don't believe it stayed that way very long, I don't remember well. Also, manganese is interesting as it seems to do positive things regarding the AQP4 aquaporin, which is involved in the glymphatic system (cleansing system of the brain). In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/nitrosative stress (ONS) mediates such swelling. As aquaporin-4 (AQP4) is important in the mechanism of astrocyte swelling, we examined the effect of manganese on AQP4 protein levels in cultured astrocytes. Treatment of cultures with manganese increased AQP4 protein in the plasma membrane (PM), whereas total cellular AQP4 protein and mRNA levels were unchanged, suggesting that increased AQP4 levels is due to its increased stability and/or increased trafficking to the PM and not to its neosynthesis. Aquaporin-4 in manganese-treated cultured astrocytes They talk about AQP4 in negative terms here but it really seems to be fundamental for the glymphatic system, for example: CSF transport is facilitated by the expression of aquaporin-4 (AQP4) water channels on the perivascular endfeet of astrocytes. Mice with genetic deletion of AQP4 (AQP4 KO) exhibit abnormalities in the brain structure and molecular water transport. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
  • PUFA & weight loss

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    U
    @LucH thank you for the "in depth" reply.