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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    543 Topics
    4k Posts
    LucHL
    @DavidPS said in Lipofuscin accumulation in aging and neurodegeneration: Dr. Peat has written about lipofuscin. Too many options (lazy). here I've got this info on my pC. *) How the Oils In Your Diet Are Aging Your Skin. Dr. Peat goes on to explain what this rancidity (oxidation process) does: "The free radicals produced in this process react with parts of cells, such as molecules of DNA and protein, and may become attached to those molecules, causing abnormalities of structure and function." https://raypeat.com/articles/articles/unsaturated-oils.shtml EGCG Inhibited Lipofuscin Formation Based on Intercepting Amyloidogenic β-Sheet-Rich Structure Conversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816542/ "Lipofuscin (LF) is formed during lipid peroxidation and sugar glycosylation by carbonyl-amino crosslinks with biomacrolecules, and accumulates slowly within postmitotic cells. The environmental pollution, modern dietary culture and lifestyle changes have been found to be the major sources of reactive carbonyl compounds in vivo. Irreversible carbonyl-amino crosslinks induced by carbonyl stress are essentially toxiferous for aging-related functional losses in modern society. Results show that (-)-epigallocatechin gallate (EGCG), the main polyphenol in green tea, can neutralize the carbonyl-amino cross-linking reaction and inhibit LF formation, but the underlying mechanism is unknown."

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    61 Topics
    696 Posts
    yerragY
    @what-about-bob Thanks. I like the summary. How everything all fits in from theae great minds and put together by Ray Peat into more practical lifestyle applicable ideas. I am appreciating how I see myself on the "applied technology" end of their contributions as I incorporate these ideas into my attempt to be my own doctor as I attempt to improve my health. I have been unable for the past 24 years to lower my blood pressure without using prescription medication. But I am seeing the light at the end of this tunnel. It is a long process of learning and I don't give up. Thanks to recent developments in science and technology, I may be able to lower my blood pressure finally using ideas from Peat and his predecessors. What has been helpful is my use of AI as an efficient research assistant and aggregator of concepts and minute details that my own limited human mind can't recall easily and utilize readily.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    10k Posts
    S
    ^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    360 Topics
    3k Posts
    engineerE
    @sunsunsun said in Separation in Pansterone bottle: @engineer btw just found this https://www.ergo-log.com/6-keto-progesterone.html Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study

  • Recipes, food, meal prep, brands. Discuss them all here.

    226 Topics
    1k Posts
    alfredoolivasA
    @heyman said in Euphoric foods: äggost Does it taste like cream cheese?

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    85 Topics
    1k Posts
    BioEclecticB
    @jamezb46 said in pre workout / intra / post workout: @BioEclectic Why do you think lactic acid produces DOMS? From what i had read at the old RPF forum, though i always hold open the possibility that i have either misconstrued or misremembered whatever i had read. Not sure if this applies but I do know it noticeably reduces work or shoe related foot soreness. Mag sulfate and Mag bicarbonate.
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  • rtR

    What do you all think about Goatis aka Sv3rige?

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    thyroidchor27T
    @EustaceBagge said in What do you all think about Goatis aka Sv3rige?: I agree with you, he looks very calm and has nice skin that is not just superficially good looking but has a great quality to it. [image: YxeQeT.gif]
  • L

    "Glucose Loading" protocol, a la Dr Stephens - A Critique

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    J
    @LetTheRedeemed said in "Glucose Loading" protocol, a la Dr Stephens - A Critique: @Janelle525 yes. I’m definitely at the pinnacle of my salt intake, haha. I lowered my sugar consumption, or at least balanced it with spreading out my protein intake, and the headaches went away. That was a while ago. And I definitely still consume quite a bit of sugar: several sodas/juice/sweat teas per day, plus spoonfuls of honey with milk, and ice cream. I’ve definitely found my max sugar capacity Haha okay!
  • PrinceTrebataP

    Transdermal Application Poll

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    Crypt KeeperC
    I'm going to not vote because I haven't felt an effect from anything I've put anywhere transdermally yet. Although I've only tried arms, tops of feet, stomach and navel.
  • W

    threonine/serine - can this substitute glycine?

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  • the MOUSET

    got palpiatations eating butter

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    F
    Are you sure it is the heart? I think it could be the gallbladder secreting more bile acid to digest the butter, sometimes it happens to me after a fat heavy meal.
  • cs3000C

    Sonoluminescence

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    MauritioM
    @cs3000 said in Sonoluminescence: https://www.youtube.com/watch?v=vpLw5nyu_Pk Wow that's extremely interesting. The comments under the video are amazing as well. I had to think about the ying-yang symbol. You have the fire in the water here , representing the white dot in the black part of the symbol. But someone applied to the Bible or the Egyptian pyramids as well. The theory existed for ages that the Egyptians used sound for building the pyramids, maybe they also created electricity with it. And in the Bible god says he is a pillar of fire in the night and a pillar of clouds during the day. Again, representing the one which combines opposites in itself, as shown in the ying-yang symbol. Seems like this hits some core truth of reality. I find the idea of making electricity from this intriguing. Even if tis not enough for fusion, it's still at least tens of thousands degrees warm, which is quite something. Can we produce this phenomenon by ourselves ?
  • hwisdomH

    Progest E for europe

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    Nyck Star GelN
    UK: https://www.balancedbodymind.com/shop/p/progesterone Norway: https://detox.no/products/progest-e Kenogen once wrote in a reply to my mail, that it is a 50/50 chance of the parcel goin through customs (germany), and the packages from norway may receive less scrutiny than packages incoming from the US. Keith from the UK store said its usually fine but austria and spain no chance
  • J

    This topic is deleted!

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  • the MOUSET

    radioactivity of potassium

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    yerragY
    @the-MOUSE Doesn't affect us. We don't keep a ton of KCl at home. We don't even use KCl except for replacing NaCl, and we hardly do if we're really Peaters‐ as we like salt and we don't have to substitute it with KCl. There are other things we could do with our time.
  • VehmicJurymanV

    Kurzgesagt argues that exercise does not cause weight loss

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    B
    @Hearthfire said in Kurzgesagt argues that exercise does not cause weight loss: Anyone who denies that calorie deficit + working out = weight loss, is FAT. Fair. With a possible rebound and disoriented sense of need at an extreme. If a person wants to rest a regime. But the opposite is a (mainstream) anomaly in many.
  • X

    No starch?

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    J
    I couldn’t really digest starch until I decided to start combining it with a moderate amount of fat, now it digests perfectly. Try making your own fries/chips using coconut oil and butter adding butter to rice etc. A baked potato with plenty of butter. When I have rice or potatoes without much fat it is often a gamble whether it will digest well.
  • W

    what is the link between potassium and baldness?

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    O
    @wester130 I'm no expert on this, but I think it's strongly related to hair loss, but then again K is related to nearly everything. Mg is probably more important to counteracting the effects of excess Ca than anything. And Mg helps preserve K as well.
  • b1B

    Can I replace water with milk?

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    T
    @short_hope I drink 1.5+ liters of whole milk, orange juice, grape juice, lots of coffee w/ milk (throughout the day), occasional coconut water, fizzy drinks with sucrose/glucose. Fluid content in the foods we eat (whole fruit, etc.) is often not included as it should be (or not easy to quantify) when people think about their fluid intake. I grew up with parents very interested in health food and maintaining good hydration. And I raised my children pushing frequent water consumption on them, which I now regret (before reading Ray Peat on 'salt to taste' and dangers of excess water intake). I think excessive worry about dehydration and excess water intake worked against my health objectives. I'm now feeling like good metabolic health has been finally achieved (last 5-8 years) after stopping water drinking. Of course still using water to cook soup/broth, boil potatoes, etc.
  • J

    Acipimox, NMN, Niacinamide and Nicotinamide Riboside

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  • Butter GirlB

    Is It My imagination? Taurine Supplementation Is Giving Me More Muscle Defintion 😀

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  • M

    Fat Consumption before TT Test

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    M
    @Mallard6146 bump
  • cs3000C

    Infrared light (heat?) powers blood flow independent of the heart

    heat blood flow infrared thyroid circulation
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    cs3000C
    @cs3000 May be key to use IR light that includes 8-10 uM wavelength , IR-C https://www.nature.com/articles/s41598-019-48187-0 which is weird because only a tiny amount of IR-C comes from the sun, and doesnt penetrate skin as well as ir-A or B. but was the wavelengths that worked on mitochondria in epithelial cells [image: 1721285996407-4e1665e9-e423-4dc6-967c-da8be1b716b8-image.png] humans might emit infrared around 9-10 uM though which matches the mitochondria study https://www.researchgate.net/post/What_is_the_IR-radiation_emitted_by_the_human_body & the embryo study used a lamp "at wavelengths ranging from 1 μm to 14 μm, with a peak at 2.9 μm."
  • X

    How to get more calories without starch or dairy

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  • hwisdomH

    Ivermectin where buy ooga

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    H
    @hwisdom https://covid19criticalcare.com/treatment-protocols/ You'll find dosage in these protocols too. Maybe you can just figure out what would work in your case. It's very safe so you can't screw up too much.
  • W

    Russian drones hit sunflower oil terminal in Ukraine

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