@sphenoid said in Thiamine almost fixed my chronic symptoms.:

I’m having a hard time understand how sugar “cancels out” thiamine. Doesn’t just this mean thiamine will be used to metabolize the sugar? Same with caffeine.

I got that info from the FAQs on Dr. Costantini's website. But from my own experience, I believe it to be true. I think the problem happens when the sugar and the thiamine are in the stomach at the same time.

About Dr. Costantini (from the link above):
"He is a neurologist in Viterbo, Italy with his own practice and 2,700 + patients that he is treating with thiamine as an adjunctive treatment to their standard PD meds. He has been treating his patients with PD for over 5 years now during which time no apparent disease progression has been observed while symptom improvement has been significant for most patients.

"As far as thiamine, he has been working with it since 2010/2011.

"He said that even if they couldn’t come to his clinic, he could still try to treat them via email. He said he needed a copy of their medical records and short videos of a Pull Test, of them talking, writing and a short video of them walking."
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Unfortunately, he died in 2020. I believe that he had more experience actually treating people using high dose thiamine hcl than anyone else. His research papers are here. I take thiamine hcl since I was unable to tolerate TTFD thiamine (the favorite of Dr. Lonsdale and Elliot Overton) because my glutathione level was very low. So I've relied on Dr. Costantini's clinical experience that is shared on his website. I value Dr. Lonsdale's and Elliot Overton's articles and videos as the information is pertinent to supplementing with high dose thiamine hcl too.

I should also say that Dr. Lonsdale and Elliot Overton and Dr. Chandler Marrs all talk about TTFD's "paradoxical" reaction which is negative side effects from taking TTFD that some patients "have to work through". In contrast, Dr. Costantini said that there should not be any negative symptoms from taking thiamine hcl and if that happened (rarely), he would take the patient off the treatment for a week and then resume with a dose half the amount as what caused the problem.

My husband takes 200mg of TTFD/day and has never had any problem from taking it.

@Hando-Jin @GreekDemiGod can't think and will believe anything charlie says on that forum, also "what is the best idealabs combo?" hurr durrr

@Lipidfree said in Bowel Movements: Sh*tmaxxing Strategies:

@Skysnek

What is usually recommended but didn't work for me regarding constipation:

Cyproheptadine at 2mg/day Thiamine HCL at 100mg/day 2 carrots per day Magnesium citrate, up to 2.5g/day

What worked but inconsistently:

Coffee, from 7g to 45g of grounds per day

Things I have yet to try but are in the books:

Cascara Nicotine

If coffee works for you, nicotine will def. work too. However, I don't believe it's the healthiest way to trigger a bowel movement.
Try Magnesium Oxide.

@pannacottas makes sense thank you!

@SalemSays I actually try to limit fat intake, might try what you suggested. Thanks!

@basednigga2006 It is impossible to dose correctly, because there are many feedback mechanism involved, and interfering by just gripping into the spokes of the wheel is dangerous. It is always better to rely on your own body, if possible. Keep it healthy and well nourished.
And find out why your cortisol is high, and work on the root cause, not the symptoms.
But if you suffer under high cortisol, blocking it for a short time may bring you relieve and may be useful to bring you out of an acute situation. But not in the long term.

@raypneat Have you tried bag breathing?

@the-MOUSE If you feel rested when you wake up it shouldn’t really be an issue. But if you feel bad when waking up it could be due to stress hormones. Maybe eat ice cream before bed. It usually results in a good nights sleep for me.

I also find that I need less sleep when I’m in good metabolic health.

@saturnmissiles Lmao conveniently enough I just started taking that supp, haven't really had any issues. I'm taking the one with mk4 + mk7.

@the-MOUSE Tattoos are well known to lead to inflammation and immune responses. Thus even if there are no studies that looked at melanoma, it may at least be a theoretical risk.
It seems to depend on the colours used. The bright colours may have more toxic metals. I herd of tattoos using black ink without heavy metals.

@TopicalsOnBalls I have noticed this effect of resistant starches too - it makes me wonder how people tolerate batch-cooked meal prep that includes a lot of re-heated rice.

Have you found a difference between eating this resistant starch cold/reheating it? I haven't tracked re-heated rice enough to say, but eating cold potatoes seems to have really irritated my poor digestive system.

@sphenoid

Definitely could be