Subcategories

• Literature Review

  Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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  @Amazoniac said in Aspirin metabolism: glycine and beyond:

  Pharmacokinetics of Salicylate in Man

  "The alkalinizing effect of sodium bicarbonate on urine pH is well known. Less widely appreciated is the fact that certain "nonsystemic" antacids can also increase urine pH. The term "nonsystemic" is therefore a misnomer. Such widely used antacids as aluminum and magnesium hydroxide and calcium carbonate-glycine mixture can increase urine pH significantly [40]. The lower the baseline urine pH, the greater is the effect of the antacid [40]. Since antacids are frequently taken concomitantly with aspirin (often without knowledge of the physician) to reduce or prevent aspirin-induced dyspepsia, an awareness of this potential interaction is important."

  Is this implying that it is actually better to take aspirin without a "buffer" like sodium bicarbonate? Edit: I read it wrong, this actually states the opposite correct?

• Ray Peat Resources

  Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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  @Mauritio such a simple concept with such radical implications for how we live and what society values

• Not Medical Advice

  Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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  @mostlylurking agreed.

• Products

  From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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  Check Qingdao sigma chemicals on thinksteroids guys.
  Also im not one to gatekeep sources and stuff but you need to search more, dont expect to be spoon fed about stuff like that. On thinksteroids if you ask for source at best they'll tell you to use the search function, at worst to fuck off for creating an unnecessary thread lol.

• The Kitchen

  Recipes, food, meal prep, brands. Discuss them all here.

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  @reasonablepete said in does butter oxidise when used as cooking oil?:

  From a chemical perspective, any cooking at medium to high heat will produce incomplete oxidation, and leave behind potentially toxic byproducts. This would be the case for any cooking oil that is not particularly stable under heat, like butter. That is probably why coconut oil is preferable.

  Why is butter not stable under heat? Maybe you're referring to the protein in butter. If you remove the protein in butter, it is called ghee. Ghee is all fat, and it is stable enough.

  You don't cook with unlimited heat to raise temperatures so much that it will exceed the flash point, where it will produce smoke, but it helps to use an oil that can take high enough temperatures that allow deep frying to be done well, such that the finished cooked product is not drenched in oil, making the attempt to deep fry a fail.

  A good deep frying oil allows for a high enough temperature so that the deep fry item will keep releasing steam from the water inside it, and the constant stream of steam coming out will not permit the surrounding oil to soak in, and the deep fried item will this be kept from becoming covered up in oil. This makes the deep fry a success.

  Ghee can take a higher temperature than refined coconut oil, the typical coconut oil used for cooking. Even if coconut oil has mostly saturated bonds, which keeps the oil stable (not oxidize), the coconut oil has many low molecular weight components, and this makes the oil unable to have a high flash point, the temperature where it starts to smoke. So it isn't a good idea to deep fry with refined coconut oil, as an oil with a high flash point is needed to deep fry. Fully hydrogenated coconut oil though, is excellent for deep frying.

• The Gym

  Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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  A

  Thanks for the replies. I'll have a look into the DC programme I've heard of it before but never tried it.

  It's a good point about the concentric, I'm going to try speeding it up to 2-3s and just keep the eccentric phase slower.

  I've read people say it should be harder on the joints but I get no joint pain at all when I do this very slow and controlled method and it always comes back it I start going faster and more explosive, even with good form.

  Reckon I'll stick with the slower tempo to keep my joints feeling good and just focus on everything else nutrition and lifestyle wise to make sure I'm minimizing any negative impact from it.