in the bodybuiling comunity its well known to be really damaging to metabolism. It can make you skinny fat really easy, hunge weight loss but also huge loss of tissue.
If anyone says this they have no idea what they're talking about and clearly never bothered to read any of the early or even recent literature and studies on DNP, Tainter's most notably, almost all of which is available on pubmed. They all think themselves clever and somehow contributing to the discourse by repeating the meme that it's a pesticide and "burns you from the inside out."
In the therapeutic and even higher dosages it has shown to be remarkably if not almost completely muscle sparing. Far more so than even thyroid hormone. It is a fat-burning drug.
There are plenty of reasons to avoid DNP but "damaging to metabolism" is not one of them.