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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    692 Topics
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    C
    And I was looking for the answer on whether FMTs are a guarantor for clearance of fungal abundance in the small intestinal or colonic lumen. Surprisingly, it's a no! It appears to be even the other way round. Here's something interesting IMO about FMTs: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection, 2018 In this study, it is shown that CDI is strongly accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Post-FMT, successful responders lack their previous C. albicans dominance but rather display a high relative abundance of Saccharomyces and Aspergillus. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. In essence, therefore, annihilation of Candida dominance in CDI patients is crucial for FMT success and arguable it could be much advisable to pre-/co-treat any CDI with antifungals along with either ABx or FMT. Another study showed contrasting results of FMT on UC: Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis, 2020 Herein they showed that in contrast to FMT in CDI, clinically successful response to FMT in UC very much depended on high Candida abundance at baseline, which decreased after FMT. The authors argue that the prior Candida dominance may provide a specific niche for bacterial engraftment, ameliorating UC. So, the very opposite of the pre-conditions in CDI. However, what the authors do not talk about in their text but what their graphs clearly show is the following caveat: UC patients with a low relative Candida abundance at baseline did not only not clinically benefit from the FMT, but their dysbiosis, inflammation and Candida levels post-FMT was mostly even larger than before (confounders? Small sample size?): [image: 1-s2.0-S1931312820301700-fx1.jpg] [image: 1-s2.0-S1931312820301700-gr2.jpg]´

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
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    H
    @GRay interesting. if it aint broke don't fix it

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    395 Topics
    4k Posts
    daposeD
    I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone

  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
    2k Posts
    Milk DestroyerM
    @alfredoolivas Perhaps, but I'm not certain. I actually was eating a lot more kale recently (maybe 150g a day) for a week and I did notice I had lost some weight (like 5lbs), but I was also walking in nature more at the time. I'll try incorporating it more consistently and get back to you.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
    1k Posts
    alfredoolivasA
    @hawk1 okay you actually had agency & balls and settled with some pretty decent sources. It took you two months, but I’m proud of you if that means anything.
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  • M

    Amoxicillin (Augmentin) gave me a diarrhea and possibly IBD flare up

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    M
    Ray said positive things about lidocaine for bleeding colitis. You might research on that for a bit. @laoa Hi, yes thank you, I'm aware of lidocaine, but the sources i've found so far feel a bit sketchy (if you have a trusted source, please share), so I think I'll try other options first. I've seen people have success with niacin, apple pectin, and xylitol (all of these should mainly work by increasing butyrate production in the gut). Also, acute gastrointestinal problems and fever could also be an allergic reaction to augmentin. Yes, but I think "allergy" is just an umbrella term for the things mainstream medicine is clueless about. Like in this case it could be that my intestinal permeability was already really bad in the first place and the Augmentin killing the bacteria in the gut and them releasing their endotoxin was the final straw, or something along those lines
  • gg12G

    How to handle blood sugar spikes at 17

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  • B

    Cancer cells actually have high NAD/NADH ratio

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  • E

    cancer

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    E
    @gg12 fat, sugar, glutamine.
  • cs3000C

    A bunch of random studies #1

    coconut oil tendon nicotinamide depression sleep
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  • gg12G

    Where do I start 17m

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    gg12G
    @LucH ah good to know thanks for some examples
  • I

    food and supplements

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    C
    @Jakeandpace Thanks for this bit of info. Essentially, that's marking out the importance of feeding sufficient nutrients and cofactors to the otherwise starving nerve cells, which are particularly strongly energy-dependent, as they become more active and craving for substrates when boosted by PLP. So it offers an explanation for adverse effects of PLP, pointing specifically to CoA and therefore vitamin B5. Which is useful. However, what remains completely untouched by this are all those adverse effects from supplementing pyridoxine which are not mediated through PLP but caused through PN, PM, PL, i.e. the adverse effects which distinguish supplementation of PLP from supplementation of PN.
  • D

    16 Years Old & Acne Issues

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  • T

    3-4am waking

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    JenniferJ
    @SpaceManJim said in 3-4am waking: Odd that nobody's mentioned it, especially after seeing your username, but... How about salt? Probably because he listed salt before bed under the things he has tried.
  • the MOUSET

    extreme dopamine detoxing peaty?

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    KilgoreK
    @the-MOUSE Maybe the terminology is wrong but I think cutting out socials, music and doing what you proposed have incredible benefits. You can fix your life in a couple months if you actually try. Even if you avoid bad things before the evening you will see great results.
  • S

    The Most Shredded 55 Year Old in the World Reveals his Diet to Get Under 5% Bodyfat - Bill Maeda

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    S
    I watched the whole vid, was intrigued from the first few mins when he described a very intuitive and somewhat Peat-related approach: lots of carbs, lower stress, high agency lifestyle. He then goes into his staple meal being red meat and rice, plus unlimited fruit, which seems like a pretty solid way to run one's diet. But it also made me think about how just being active every day is such a huge factor in one's body composition. This guy, like many YT fitness influencers, don't have "real" and sedentary jobs, including stressful commutes. They just live a "more natural" life, are on their feet way more, always moving, don't have low-grade stress associated with constant use of Microsoft Office products (lol!). I've noticed this effect pretty pronounced in myself. I'm an office worker by day with side business ambitions I work on during evenings and weekends when possible, so it's a lot of 'modern day office work'. I also do intense weight training 3x a week and a few bouts of cardio via martial arts, so I'm in reasonable shape - strong with slightly visible abs and ~15% bodyfat. But when I'm not working, not having an alarm clock, for extended periods of time, my physique just takes on that extra ~25% of quality that's hard to describe - everything feels and looks tighter, more abs visible while at same body weight, energy levels and lifts are maybe 10% better automatically, etc. I tolerate any and all foods way better too. I really get the sense that if I focused on living life this way for more than a few weeks on vacation here or there, I could be making these dumb "here's my life as a fitness guy" videos lol. Just being on my feet walking some European city on vacation for a few days does incredible things compared to standard north American life, and people like Bill live closer to the former than the latter everyday. Not meant to brag, but rather to say that I believe most anyone could quickly and continuously improve their physique and physical well-being if they make appropriate trade-offs in life. And I'm sure those of us stuck in the corporate North American grind can continue to find and apply principles to improve our health and fitness too.
  • the MOUSET

    thoughts on just following elemental diet?

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    the MOUSET
    @the-MOUSE #tnd
  • ?

    demoralization / blackpoll propaganda is cringe

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    Milk DestroyerM
    @sneedful The thing is I don't think that sort of escalation is impossible but panic posting about it is not helping. Unless he is inviting us all round his place for tacos?
  • I

    This topic is deleted!

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  • W

    glutamine? good or bad?

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    LucHL
    @wester130 said in glutamine? good or bad?: why is gelatin so high in glutamine? We don't use gelatin for glutamine but for collagen. Collagen is rich in glycine and proline. Glycine is going to moderate the possible excito-toxicity of glutamate (change of glutamine into glutamate (glutamic acid) in the process of assimilation, partially). Collagène composition: Protéine 86 – 92 % Glycine: +/ 30 % (+5 / -9) Proline: +/ 18 % (-6) Hydroxyproline: +/ 14% (-2 / +2) Alanine: 11 % (-2 / +1) Lysine: 5 % (-1) NB: Pour le collagène selon Ray PEAt, myprotein .com, Great lakes. Si prise de glycine : 2 x 5 g, assimilation 20 % selon un post de Haidut.
  • I

    This topic is deleted!

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  • S

    high b12 from blood test

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  • SugarS

    What peaty substance is closest to cannabis/CBD on mental and physical relaxation?

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    E
    @LucH said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?: @Ecstatic_Hamster said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?: CBD is not deleterious to neurons. Where did you get that idea. It helps inhibit excessive neuronal firing. Cannabinoids reduce brain connectivity I know several studies demonstrate beneficial effects on pain. Mercola has written a thunderous article on the benefits of medical cannabis. I remember having heard a psychiatrist (radio interview) saying we lost partial connectivity from neurons, becoming useless. But as we only use 10 % of our capacity, problems shouldn’t arise, unless teenagers begin to regularly smoke cannabinoids. Marijuana is however safer than cocaine, but with new synthetic mix drugs, it’s another problem… Excerpt The study’s findings revealed significant disruptions in brain connectivity across several key networks after cannabis administration. These networks include the executive control network (ECN), salience network, hippocampal network, and limbic striatal network. Specifically, the ECN, responsible for higher-order cognitive functions like decision-making and cognitive control, showed reduced connectivity under the influence of both THC and THC + CBD. Source: New neuroscience research: CBD does not temper THC’s effects on brain connectivity, may enhance disruption. In PsyPost, by Eric W. Dolan July 23, 2024 in Psychopharmacology Brain > Cannabis. https://www.psypost.org/new-neuroscience-research-cbd-does-not-temper-thcs-effects-on-brain-connectivity-may-enhance-disruption/ Thank you for posting this. It isn’t my experience and I don’t think this is much of a study. But I appreciate it. I never gave this one any credence. There are much better studies that show the opposite.
  • T

    Idealabs Solvent

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    BaseBornPeaterB
    @temple-of-salt I believe the main purpose of the SFA/ ethanol mixture is that it should greatly increase topical absorption of whatever is dissolved in it. Really great for stuff like vit K where a good topical dose would end up in me cutting up several capsules and mixing them with coconut oil on my legs. The olive oil may still be preferable for topical use on more sensitive areas, or for making into diy cosmetics etc. I’m unsure if one is better than the other for oral use other than olive oil being more pleasant to squirt into your mouth.
  • ?

    Dates

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    DavidPSD
    Haidut recently wrote That corroborates Ray’s views that one should be careful when consuming foods naturally high in 5-HT such as kiwis, dates, and (unripe) bananas. http://haidut.me/?p=2700 Peatbot.com: The context provided suggests that there are concerns about the use of 5-HTP (5-hydroxytryptophan), which is a precursor to serotonin. It is mentioned that while 5-HTP might elevate mood, it could also have potential negative effects. These include an increased risk of breast cancer, obesity, and other adverse effects due to its role in raising serotonin levels. Excess serotonin is associated with increased estrogen, which can slow liver metabolism, suppress thyroid function, and potentially lead to obesity and cancer. Therefore, while 5-HTP is sometimes used as a natural supplement to boost serotonin, there are significant concerns about its long-term health effects.