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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    626 Topics
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    U
    Increased Androgens: A pilot study on male volunteers (1 g/day for 1 month) found that DCI administration was associated with a +23.4% increase in testosterone and a +13.8% increase in dehydroepiandrosterone (DHEA). Reduced Estrogens: In the same study, DCI significantly reduced estrone levels (-85.0%) and reduced estradiol levels (-14.4%). Androgen Precursors: In addition to DHEA, other androgen precursors like epiandrosterone also increased (+39%). Aromatase Inhibition: DCI is believed to act as an aromatase down-modulator (inhibitor), reducing the conversion of androgens (like testosterone) into estrogens (like estradiol and estrone). D-chiro-inositol (DCI) acts to stimulate PDHP (pyruvate dehydrogenase phosphatase), which in turn dephosphorylates and activates PDH (pyruvate dehydrogenase). Insulin Mimicry: DCI has been shown to reduce the concentration of required for full activation of PDHP, a mechanism similar to how insulin works in adipocytes

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    702 Posts
    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    10k Posts
    LucHL
    @engineer said in Too high systolic blood pressure?: Should I keep using them or or lay them off? I'd stop the whole thing for 3 days. To avoid interference with half-life molecule and a return to +/ balance. Then I'll see the the interconnection of the molecules and the lack of. If you stress, you lack magnesium bisglycinate. There is interaction between B1 B2 B3 B6 + B8iotine. No more than 20-25 B3 if niacin (histamine flush). Here no caffeine until it's fine. wait 5 days. Need carbs (glucose & fructose with fiber) when taking caffeine again. Half life is 5-6 hours for caffeine. Too much caf interfere with adenosine and serotonin afterwards. And don't take a high dose because you've already done it before and everything was alright... Need l-theanine if you're angry / disturbed / in bad temper ... + a relax technique (breath) for 3'.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    383 Topics
    4k Posts
    loessL
    Wow, glad you're feeling a lot better. I think I might actually be experiencing something similar and I hadn't even considered it. I packed away my UV lamp in January in preparation for a move, and shortly after that started supplementing daily 5000 IU of vitamin D in olive oil because I had gotten lab results that came back low for 25-OH vitamin D @ 30 ng/mL. It's the larksupply.co vitamin D, which is pretty much unparalleled as far as quality. I think I just simply don't tolerate oral vitamin D for whatever reason. Since I got to my new place at the beginning of February I haven't been myself at all. My sleep has been inconsistent, full of interruptions for no reason, and waking up has felt like being a vampire glued to the inside of a dark coffin. I've been super lethargic, and I'd also describe my mood and perceptual capacity as both stupid and irritable. Have also been hit with random nonsensical bouts of anxiety and fear that are way out of my norm. I've been so out of wack and dragging that I haven't bothered to get that lamp out and set it up since I got here. I thought it was remnants of the flu that knocked me down a week before I moved, but I think it is very possible that the vit D supplementation might actually be responsible for seriously messing me up since I arrived here. Cutting it out and going back to the lamp.

  • Recipes, food, meal prep, brands. Discuss them all here.

    233 Topics
    2k Posts
    LukeL
    You can try to find a good Thai Curry paste without bad ingredients like seed oils. They are available with red, yellow or green color. Sauté some vegetables in a pot (Onions, carrots, zucchini, peppers, whatever you like - if you use broccoli, better cook it in water before, otherwise it will be half raw). Add meat, white fish or shrimps. Add the curry paste and mix everything. Add coconut milk and let it simmer for five minuted or so. Serve with rice.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    85 Topics
    1k Posts
    alfredoolivasA
    @sunsunsun https://www.youtube.com/watch?v=7f25pFhuAaY
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  • S

    high b12 from blood test

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  • SugarS

    What peaty substance is closest to cannabis/CBD on mental and physical relaxation?

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    @LucH said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?: @Ecstatic_Hamster said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?: CBD is not deleterious to neurons. Where did you get that idea. It helps inhibit excessive neuronal firing. Cannabinoids reduce brain connectivity I know several studies demonstrate beneficial effects on pain. Mercola has written a thunderous article on the benefits of medical cannabis. I remember having heard a psychiatrist (radio interview) saying we lost partial connectivity from neurons, becoming useless. But as we only use 10 % of our capacity, problems shouldn’t arise, unless teenagers begin to regularly smoke cannabinoids. Marijuana is however safer than cocaine, but with new synthetic mix drugs, it’s another problem… Excerpt The study’s findings revealed significant disruptions in brain connectivity across several key networks after cannabis administration. These networks include the executive control network (ECN), salience network, hippocampal network, and limbic striatal network. Specifically, the ECN, responsible for higher-order cognitive functions like decision-making and cognitive control, showed reduced connectivity under the influence of both THC and THC + CBD. Source: New neuroscience research: CBD does not temper THC’s effects on brain connectivity, may enhance disruption. In PsyPost, by Eric W. Dolan July 23, 2024 in Psychopharmacology Brain > Cannabis. https://www.psypost.org/new-neuroscience-research-cbd-does-not-temper-thcs-effects-on-brain-connectivity-may-enhance-disruption/ Thank you for posting this. It isn’t my experience and I don’t think this is much of a study. But I appreciate it. I never gave this one any credence. There are much better studies that show the opposite.
  • T

    Idealabs Solvent

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    BaseBornPeaterB
    @temple-of-salt I believe the main purpose of the SFA/ ethanol mixture is that it should greatly increase topical absorption of whatever is dissolved in it. Really great for stuff like vit K where a good topical dose would end up in me cutting up several capsules and mixing them with coconut oil on my legs. The olive oil may still be preferable for topical use on more sensitive areas, or for making into diy cosmetics etc. I’m unsure if one is better than the other for oral use other than olive oil being more pleasant to squirt into your mouth.
  • ?

    Dates

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    DavidPSD
    Haidut recently wrote That corroborates Ray’s views that one should be careful when consuming foods naturally high in 5-HT such as kiwis, dates, and (unripe) bananas. http://haidut.me/?p=2700 Peatbot.com: The context provided suggests that there are concerns about the use of 5-HTP (5-hydroxytryptophan), which is a precursor to serotonin. It is mentioned that while 5-HTP might elevate mood, it could also have potential negative effects. These include an increased risk of breast cancer, obesity, and other adverse effects due to its role in raising serotonin levels. Excess serotonin is associated with increased estrogen, which can slow liver metabolism, suppress thyroid function, and potentially lead to obesity and cancer. Therefore, while 5-HTP is sometimes used as a natural supplement to boost serotonin, there are significant concerns about its long-term health effects.
  • the MOUSET

    how matt stonie competitior eater still good health idnicator?

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    the MOUSET
    @the-MOUSE you fattys keep coping. john pork is calling me i must attend
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    This topic is deleted!

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  • M

    Low Estrogen from Androsterone

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    G
    I have experienced the same. I started using it without any bad side effects, and I took andro on off for a couple months. After awhile worse and worse symtoms such as low libido (My sex ability was fine but my desire was near 0), anhedonia, apathy all manifested which scared me as they were strong. It took some time but eventually I correlated this to low estrogen and I went to have my levels checked and they came back as: estradiol: 95 (pmol/L) testosterone: 26 (nmol/L) free testosterone: 15(nmol/L) SHBG: 28(nmol/L) The estrogen is right in the middle of the reference range which was very strange. I did still feel all the symptoms but I hadn't taken the Andro for a couple of days before the test. Aromatase Inhibitors are quite scary, I read on Excelmale forum about something called PAMD or Post AI Major Dysfunction where symtoms are basically like PSSD from finasteride or SSRIs. https://www.excelmale.com/threads/persistent-low-e2-symptoms-lasting-long-after-crash-possible-solution-or-a-little-relief.27402/ Now a couple months after I still don't feel back to how I was but I am able to function. I didn't use much Andro but on one occasion I applied roughly 20 drops to my scrotum (it is following this that much of the negative symptoms started).
  • T

    Pansterone

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    @temple-of-salt https://lowtoxinforum.com/threads/pansterone-liquid-pregnenolone-dhea-mix.7426/ personal thoughts: he has changed the formula a lot of times I think there is a big difference with the alcohol and oil solution It's probably his best supplement it's effective, it shouldn;t convert to estrogen but it will in sickly people
  • cs3000C

    Erosive Arthritis (Osteoarthritis not rheumatoid), ray peats article + case report in fingers using thyroid

    arthritis calcification cartilage joints osteoarthritis
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    DavidPSD
    @cs3000 said in Erosive Arthritis (Osteoarthritis not rheumatoid), ray peats article + case report in fingers using thyroid: Thyroid + Famotadine should be effective for osteoarthritis restoration Thiamine (B1) is also a carbonic anhydrase inhibitor. It might be useful here as well. Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules
  • M

    When to take Cyproheptadine for sleep?

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    Milk DestroyerM
    @DkJoe2 I wonder if exogenous l-dopa would convert instead to adrenaline though? And is tyrosine use safe, it being a standalone amino-acid? I suppose it'd be a matter of individual experimentation
  • L

    Body Temperature higher in the morning than in the evening

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    JenniferJ
    @leon-damjanov, it sounds like you run on stress hormones to compensate for poor thyroid function. Adrenaline raises temps and lowers TSH, giving the false impression that thyroid function is good. The biggest give away to me are cold extremities. Adrenaline cuts off circulation to extremities to keep vital organs warm when thyroid function is poor. The stress of darkness and fasting at night may be triggering adrenaline, causing your temp to be normal in the morning, while eating throughout the day lowers adrenaline, resulting in lower temps and revealing what your actual thyroid function is. Regarding weight, I’m thin, consume a lot of calories for my size and activity level, and have a history of running on adrenaline due to a weak thyroid. Ray Peat talked about people like us whose hypothyroidism often goes untreated because we aren’t overweight.
  • ?

    This topic is deleted!

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  • GreekDemiGodG

    Cold seasons - adjustments in nutrition

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    LothricL
    A lot of bone broth, potatoes, pot roast, cheese, sourdough bread. I essentially adopt what you would expect an English medieval peasant to consume
  • M

    Low Haemoglobin

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    yerragY
    @mavuue You have to go back to the time your CBC blood work began to show these poor numbers and retrace to that time to figure and out what changed in terms of sickness, a change in lifestyle etc This way, I can hazard some guesses on why your blood work took a turn south
  • I

    Study finds that higher metabolism

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    ?
    @Insomniac cool thx
  • ?

    it is fall and going into winter here and I felt a warmth today outside by some evergreen shrubs

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    ?
    my urine is a deep yellow and it seems structured. like, times I am stressed and peeing frequently and light coloured, it is basically like water in texture. when I am feeling good and urinating my urine shimmers and when I touch it, it doesn't feel like plain water. It is structured cellular water. I know all this because I pee in a cup then pour it down the drain.
  • Rayoshi PufamotoR

    Growth Plates

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    ?
    @Rayoshi-Pufamoto just do the food sir. maybe 1 deop of k2 mk4
  • GardnerG

    Why did Ray Peat change his mind on sugar

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    yerragY
    @Goodman said in Why did Ray Peat change his mind on sugar: From book "Nutrition For Women" by Ray Peat, "I have seen publicity about something called the NASA astronauts' diet, and was impressed by the large amount of refined sugar in it. He wasn't impressed with all the research from NASA. He considered HRV (heart rate variability) a fad. But HRV is the glue of of ringcore that began with the Oura ring. But all it is is glorified old heart rate measurement technology derived and spun into a hodgepodge stew of questionable biomarkers that is more marketing than science, based on it being from NASA 'rocket science.' Dressed up additionally in the garments of AI, it should keep selling well into the age of wearables with brands like Polar, Samsung, and Apple joining in the fray.
  • P

    Dream Peater Housing?

    Moved
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    serotoninskepticS
    @Pooooop -sun room -plants -high in the mountains -warm -good air flow -access to natural bodies of water -sense of community -colorful scenary -unique/personality
  • C

    System Dynamics for Peat's ideas

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    serotoninskepticS
    @Chris2401 I do a sort of combination of randle cycle, peating, and raw till 4 lol. Fruit, sugar, honey, and juices all day long with one cooked protein/fat heavy meal.