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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    692 Topics
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    C
    And I was looking for the answer on whether FMTs are a guarantor for clearance of fungal abundance in the small intestinal or colonic lumen. Surprisingly, it's a no! It appears to be even the other way round. Here's something interesting IMO about FMTs: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection, 2018 In this study, it is shown that CDI is strongly accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Post-FMT, successful responders lack their previous C. albicans dominance but rather display a high relative abundance of Saccharomyces and Aspergillus. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. In essence, therefore, annihilation of Candida dominance in CDI patients is crucial for FMT success and arguable it could be much advisable to pre-/co-treat any CDI with antifungals along with either ABx or FMT. Another study showed contrasting results of FMT on UC: Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis, 2020 Herein they showed that in contrast to FMT in CDI, clinically successful response to FMT in UC very much depended on high Candida abundance at baseline, which decreased after FMT. The authors argue that the prior Candida dominance may provide a specific niche for bacterial engraftment, ameliorating UC. So, the very opposite of the pre-conditions in CDI. However, what the authors do not talk about in their text but what their graphs clearly show is the following caveat: UC patients with a low relative Candida abundance at baseline did not only not clinically benefit from the FMT, but their dysbiosis, inflammation and Candida levels post-FMT was mostly even larger than before (confounders? Small sample size?): [image: 1-s2.0-S1931312820301700-fx1.jpg] [image: 1-s2.0-S1931312820301700-gr2.jpg]´
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    H
    @GRay interesting. if it aint broke don't fix it
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    daposeD
    I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone
  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
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    Milk DestroyerM
    @alfredoolivas Perhaps, but I'm not certain. I actually was eating a lot more kale recently (maybe 150g a day) for a week and I did notice I had lost some weight (like 5lbs), but I was also walking in nature more at the time. I'll try incorporating it more consistently and get back to you.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
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    alfredoolivasA
    @hawk1 okay you actually had agency & balls and settled with some pretty decent sources. It took you two months, but I’m proud of you if that means anything.
  • how matt stonie competitior eater still good health idnicator?

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    the MOUSET
    @the-MOUSE you fattys keep coping. john pork is calling me i must attend
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  • Low Estrogen from Androsterone

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    G
    I have experienced the same. I started using it without any bad side effects, and I took andro on off for a couple months. After awhile worse and worse symtoms such as low libido (My sex ability was fine but my desire was near 0), anhedonia, apathy all manifested which scared me as they were strong. It took some time but eventually I correlated this to low estrogen and I went to have my levels checked and they came back as: estradiol: 95 (pmol/L) testosterone: 26 (nmol/L) free testosterone: 15(nmol/L) SHBG: 28(nmol/L) The estrogen is right in the middle of the reference range which was very strange. I did still feel all the symptoms but I hadn't taken the Andro for a couple of days before the test. Aromatase Inhibitors are quite scary, I read on Excelmale forum about something called PAMD or Post AI Major Dysfunction where symtoms are basically like PSSD from finasteride or SSRIs. https://www.excelmale.com/threads/persistent-low-e2-symptoms-lasting-long-after-crash-possible-solution-or-a-little-relief.27402/ Now a couple months after I still don't feel back to how I was but I am able to function. I didn't use much Andro but on one occasion I applied roughly 20 drops to my scrotum (it is following this that much of the negative symptoms started).
  • Pansterone

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    @temple-of-salt https://lowtoxinforum.com/threads/pansterone-liquid-pregnenolone-dhea-mix.7426/ personal thoughts: he has changed the formula a lot of times I think there is a big difference with the alcohol and oil solution It's probably his best supplement it's effective, it shouldn;t convert to estrogen but it will in sickly people
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    DavidPSD
    @cs3000 said in Erosive Arthritis (Osteoarthritis not rheumatoid), ray peats article + case report in fingers using thyroid: Thyroid + Famotadine should be effective for osteoarthritis restoration Thiamine (B1) is also a carbonic anhydrase inhibitor. It might be useful here as well. Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules
  • When to take Cyproheptadine for sleep?

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    Milk DestroyerM
    @DkJoe2 I wonder if exogenous l-dopa would convert instead to adrenaline though? And is tyrosine use safe, it being a standalone amino-acid? I suppose it'd be a matter of individual experimentation
  • Body Temperature higher in the morning than in the evening

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    JenniferJ
    @leon-damjanov, it sounds like you run on stress hormones to compensate for poor thyroid function. Adrenaline raises temps and lowers TSH, giving the false impression that thyroid function is good. The biggest give away to me are cold extremities. Adrenaline cuts off circulation to extremities to keep vital organs warm when thyroid function is poor. The stress of darkness and fasting at night may be triggering adrenaline, causing your temp to be normal in the morning, while eating throughout the day lowers adrenaline, resulting in lower temps and revealing what your actual thyroid function is. Regarding weight, I’m thin, consume a lot of calories for my size and activity level, and have a history of running on adrenaline due to a weak thyroid. Ray Peat talked about people like us whose hypothyroidism often goes untreated because we aren’t overweight.
  • This topic is deleted!

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  • Cold seasons - adjustments in nutrition

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    LothricL
    A lot of bone broth, potatoes, pot roast, cheese, sourdough bread. I essentially adopt what you would expect an English medieval peasant to consume
  • Low Haemoglobin

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    yerragY
    @mavuue You have to go back to the time your CBC blood work began to show these poor numbers and retrace to that time to figure and out what changed in terms of sickness, a change in lifestyle etc This way, I can hazard some guesses on why your blood work took a turn south
  • Study finds that higher metabolism

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    ?
    @Insomniac cool thx
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    ?
    my urine is a deep yellow and it seems structured. like, times I am stressed and peeing frequently and light coloured, it is basically like water in texture. when I am feeling good and urinating my urine shimmers and when I touch it, it doesn't feel like plain water. It is structured cellular water. I know all this because I pee in a cup then pour it down the drain.
  • Growth Plates

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    @Rayoshi-Pufamoto just do the food sir. maybe 1 deop of k2 mk4
  • Why did Ray Peat change his mind on sugar

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    yerragY
    @Goodman said in Why did Ray Peat change his mind on sugar: From book "Nutrition For Women" by Ray Peat, "I have seen publicity about something called the NASA astronauts' diet, and was impressed by the large amount of refined sugar in it. He wasn't impressed with all the research from NASA. He considered HRV (heart rate variability) a fad. But HRV is the glue of of ringcore that began with the Oura ring. But all it is is glorified old heart rate measurement technology derived and spun into a hodgepodge stew of questionable biomarkers that is more marketing than science, based on it being from NASA 'rocket science.' Dressed up additionally in the garments of AI, it should keep selling well into the age of wearables with brands like Polar, Samsung, and Apple joining in the fray.
  • Dream Peater Housing?

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    serotoninskepticS
    @Pooooop -sun room -plants -high in the mountains -warm -good air flow -access to natural bodies of water -sense of community -colorful scenary -unique/personality
  • System Dynamics for Peat's ideas

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    serotoninskepticS
    @Chris2401 I do a sort of combination of randle cycle, peating, and raw till 4 lol. Fruit, sugar, honey, and juices all day long with one cooked protein/fat heavy meal.
  • Looking for safe Contraceptives.

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    ?
    Some good info here https://www.tcoyf.com/fertility-info/
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    JenniferJ
    The molestation I experienced began around age 5 and went on for years. I remember in great detail what happened, what I was thinking while it was happening, but it doesn’t carry with it the energetic weight it used to. I feel nothing now when I think of it and the one who abused me. I’m not angry, resentful, distrustful of all people. I am, however, more aware of the read I get on people, sensing their energy, and I trust my instincts. I can share in detail an example if anyone thinks it would be beneficial to the discussion, but I’ve avoided being assaulted as an adult many times because I don’t write my feelings/intuition off as an unwarranted side-effect of being abused, something that happens far too often because of common beliefs, and assumptions made, about women who have suffered abuse. Jokes about women with “daddy issues” comes to mind. My family life was and still is challenging, but that’s life. There will always be challenges in relationships, however, the difference now is how I respond to them. Now I’m honest about my feelings—for better or worse, I don’t hold back—and I’m able to let harmful relationships go. I thought for sure that I was going to take my “shameful” secret with me to my grave and would forever fear my words, associating them with death because I grew up with a mother who was suicidal and understandably she was easily triggered, but my filter broke when my spine collapsed in my late 20s and my truth came out. The physical pain of the disease and subsequent injury were unimaginable, but I know it happened for me, and for those I have helped because of it.
  • How to come off of thyroid supplementation?

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    serotoninskepticS
    @mavuue Hmm i guess you could experiment with coming off. It would only take like 2 weeks max for natural thyroid function to re ignite
  • Does anyone take a multivitamin? What to look for in it?

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    LucHL
    @BioEclectic said in Does anyone take a multivitamin? What to look for in it?: interesting note about the B50 complex. I recall you mentioning before but i don't recall the backup detail (?) That potentially harmful? AMPK sensor: Friend or foe? @BioEclectic Starting point: Too much of a good thing can become counterproductive (cancer). BioEclectic, a forum user on bioenergetic.com, recently asked me why it was not appropriate to regularly take a complex Vitamin B50 supplement. OK if it's 2x/week or these are the RDA if taken regularly, knowing that we will then have chosen a co-enzymated form (with cofactors), without yuck ingredients. (…) Short answer: AMPK functions as an energy sensor in our cells. This sensor plays a key role in the balance between anabolic and catabolic programs for cellular homeostasis in response to metabolic stress. In the case of a tumor, the cancer cell attempts to slow down oxidative metabolism and works to divert the supply of glucose for its own benefit in order to grow. The cancer cell will therefore try to down-regulate the influence of AMPK, which acts a little too much like a traffic agent to supply the different organs, instead of promoting the flow of fuel to the advantage of his own needs. So, what the link with cancer? Taking high dose of thiamin (B1) or pyridoxine PLP (B6) – they are just 2 examples of antioxidant – they act to moderate the AMPK sensor, to dampen the effects. Right in cure or if the dose turns round RDA but not for prolonged use. Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems. Cancer cells try to moderate / neutralize anti-stress. Full answer on my forum, with link in English and in French (translator needed). Cancer cells are usual, at a certain age, and have to be considered “normal” if the size does not exceed a €2 coin… AMPK as a regulator of energy metabolism How much B vitamins do we need, in which proportions? How can we modulate the sensitivity of the regulation? Cancer cells divert the supply of fuel and try to avoid oxidative stress. What’s the link between B1 and cancer growth? Targeting the AMP-Activated Protein Kinase for Cancer purpose?