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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    yerragY
    @Ena said: Yes, statins possess antibacterial properties, so in principle they will introduce LPS by helping the white blood cells to kill bacteria. But it's a strange wording, so I don't understand what he means either. @Ena said: Yes, statins possess antibacterial properties, so in principle they will introduce LPS by helping the white blood cells to kill bacteria. But it's a strange wording, so I don't understand what he means either. I think so too. Stating are antibacterial though they are not marketed to be anything else but a cholesterol lowering drug. Otherwise why would they lead to increasing endotoxins.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    @ChroncStresChris yes generally speaking, because DHT dries you out and may actually reduce tesosterone testosterone is "wet" and is needed with dht, dht is "dry"
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    D
    Who knows if this Lead Safe Mama person is actually reliable or not? I continue to use Great Lakes because I don’t know any better brand.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    JenniferJ
    @Mossy, do you mean the brand or type of French bread like the baguette? I was trying to think of popular French brands, but couldn’t come up with any. That’s great! My grandmother used red potatoes too for her potato salad. Aside from digestibility—baby potatoes typically being easier to digest—the best potato really depends on its growing conditions and less so the variety, IME. After spending months testing numerous varieties from different suppliers, I (happily) settled on the baby Yukons. They’re from a local supermarket chain and even better than the Upstate Abundance—they’re consistently so creamy and flavorful that they don’t need any added butter or salt, but they’re half the price and available year round. Alexandre is excellent, yes, but prior to caring for my dad, the majority of my dairy (and eggs) came from a local 100% grass-based, biodynamic, A2 certified (raw) dairy farm that practices Calf at Foot where the calf stays with its mother, something that’s important to me. I’ve known the owner for over 16 years now. I found his farm just after my spine collapsed and I was recovering from veganism. After hearing what happened to me, he started supplementing his herd’s diet with sea minerals to give me the most nutrient dense milk possible. The man is an earth angel. We geek out on health and science whenever I get the chance to visit the farm. He introduced me to the French scientist Louis Kervran and his controversial theory of biological transmutation and last time I saw him, he had started using a refractometer to test the Brix of his herd’s milk. Thank you for the heads-up on Vital Farms. I saw a YouTube video on it a month or so ago. I had always assumed their hens were fed supplemental feed containing soy as it’s a common practice in the industry, even for pastured. I don’t know of any brand on the market whose hens are fed entirely on pasture—Angel Acres Farm, owned by the ‘Strong Sistas’, sells eggs that are tested to be low in PUFA, though—or if it’s even possible to maintain the health of the hens and egg production to meet demands, while keeping the cost of eggs reasonable enough to not offend the consumer. With that said, I haven’t bought their eggs since maybe 2024. I buy a “humanely hatched” brand that uses the technology in-ovo sexing to end the practice of chick culling. It’s great that you’re tolerating bananas better. That’s another good indication your health has improved. Did cooked bananas also cause a serotonin response, previously? If I’m not mistaken, Ray recommended cooking them because of the raw starch. I used to only tolerate them raw when overripe. I haven’t had them in quite some time, though. My diet was further simplified because I’m having to prepare 6 meals a day, currently. Thankfully, I overcame the dysautonomia so the only effect protein has on me now is positive, but the majority of my fuel came from potatoes—I was averaging upwards of 4 lb daily. The concentrated carbs helped, but it was immersing myself in nature regularly on the trail that was most responsible for calming my nervous system and restoring my thyroid function so my adrenals weren’t having to compensate with adrenaline. I had this epiphany that it was not my body that needed convincing it was safe to relax, but me who needed it. I’ve heard it said that we should get out of our comfort zone, but it occurred to me that I’ve never had one. Figuratively speaking, I’ve been putting out fires since I was a child and always preparing for the next one. I knew I needed to take my healing beyond the cell back to the self, but it was challenging to do so when I felt so disconnected from myself, hollow even, since my mum’s passing and distracting myself with the demands of caring for my dad wasn’t going to reconnect me. I didn’t overcome the dysautonomia overnight, but I stayed committed to getting out on the trail at least 4 days a week, and one day, while on the last mile stretch of one of my hikes, I had a moment, a breakthrough, when there was what I can only describe as a lifting of the veil between this world and heaven. I thought I knew peace, but just like hell has no floor, the depths of it are endless, I discovered that day that heaven has no ceiling. To go from feeling completely disconnected to feeling connected to not just myself but everything, to know life’s tragic realities, intimately, and at the same time its miraculousness, was life-affirming. I was reminded that the source that created the mountains I’ve climbed is the same source that created me to be just as enduring, and whatever comes my way I can handle it because in hindsight I always have, and where, in the past, I would have gone into fire-extinguisher mode hearing the doctor say my dad had what killed my mum, I felt at ease, in the flow and have remained so. I’m not just drifting around the ocean on a surfboard, at the mercy of the water. I am the water. And thank you. ️ Yes, you can definitely relate. Being a caregiver is a lot, but I’m just so grateful to have more time with my dad that I didn’t have with my mum.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    C
    I thought aspirin and/or baking soda w water is good for afterwards? Gummy bears or fruit before and during lifting, no?
  • Zonulin and its Consequences

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    stagS
    @LucH That's a very comprehensive paper, thanks for sharing! I didn't mean that zonulin is a protective inhibitor, I was referencing that substances that inhibit zonulin (like Larazotide acetate) are protective against its deleterious effects (like type 1 diabetes / celiac), as elaborated on in the papers we have both posted. @LucH said in Zonulin and its Consequences: For me zonulin is secreted in presence of excess lectins and gliadin (agglutinin family) to avoid aggregation with L-glutamine from the membranes. Zonulin acts as a garde-barrière, telling the body to let the toxins get away. Zonulin tells the tight junctions to stay open … Do you have more info on this? A search for lectins and leaky gut discloses this article: Lectins: The Gluten-Lectin-Leaky Gut Connection Some lectins that we consume in everyday foods can bind to the sugars in the cell walls of the gut or in the blood. This can cause an immune response, leading to inflammation, intestinal damage, altered gut flora, malabsorption, decreased cellular repair, cellular death, and eventually disease. These lectins bind to glycoproteins and glycolipids (sugar-coated proteins and fats) found on the surface of human and other animal cells. This binding allows for agglutination (clumping) and sometimes can produce an immune response. They can cause agglutination of blood cells and they can bind to the cells that line the small intestine. This article also references Fasano, he seems to be a popular guy in zonulin world. The relevant reference regarding lectins is here (I think): Dietary lectins are metabolic signals for the gut and modulate immune and hormone functions A related paper is here: Characteristics and consequences of interactions of lectins with the intestinal mucosa Following general Peat diet suggestions will have you avoiding most lectin-containing foods anyway, but there are two that stick out: dairy and nightshades. Someone could be getting most of their calories from milk and potatoes thinking theyre fine because its Peaty but may be driving intestinal permeability due to the lectin content. The example given in the article of a noxious lectin is wheat germ agglutinin. I wonder how bad non-wheat derived lectins like those from potatoes and milk are. If the mechanism is as described I also wonder if it may be advisable to keep dietary gluten and lectins to a minimum during L-glutamine supplementation, as that combination may provide ample reason for a zonulin trigger. This will be easy for wheat, likely also potatoes, but cutting milk may prove to be a challenge, if necessary. It also may be the case that the supraphysiological doses of glutamine generally used in supplementation may override any zonulin signaling caused by incidental dietary lectins. I'm not sure.
  • thoughts on this vid from foid saying seed oil harmless

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    LetTheRedeemedL
    Lol bling became cool last second. Rip
  • Marijuana as an Intestinal Anti-inflammatory

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    ?
    look up cannabis hypermesis syndrome to find out what happens to some people after long term marijuana smoking.
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  • 3 liters of whole milk a day

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    AndrosclerozatA
    @Cezar4911 also I got a powerful warmth that was uncomfortable, similar to high protein meal
  • Pregnenolone's impact on a woman's cycle?

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    @FOR-THE-POTATO This is off topic....
  • thoughts? debloating, aldosterone and acne

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  • Suppression of Haidut's Cancer Cure

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    ChudC
    @the-MOUSE you dont really need hair once your his age and already have wife/kids. and being built like that is peaty. also 1.5 liters chocolate ice cream/day diet cures hairloss but you need to supp bicarb, sunbathe, and do nofap for it to take effect.
  • Taking zinc/copper/selenium and iodine for thyroid

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  • Rate the Supplement Stack of a Canadian Peater

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    PrinceTrebataP
    @Nomanarch A large amount of peaters I meet online either here or on the RPF are from Canada including me. It's interesting because I would think for our size it would be much rarer to see a Canadians on here. To answer your question though all the substances you use are good and peaty but it can be excessive if your taking them everyday. t3 and t4 are easily acquired via meds.com.mx. I had no problems getting mine through customs. Besides that ensuring you have adequate carb intake, salt to taste, eating gelatinous foods. Some other supplements you can think about trying in the future are Progest e, Pregnenolone, and Cyproheptadine.
  • Protein synthesis / net carbs

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    Purp1eOneP
    @Jennifer said in Protein synthesis / net carbs: “*Protein: (about 15-20% calories) .6-.8g/lb. Protein should be on the higher end if you are active, or you are older. Protein sources should be from ruminant meat (beef, bison, lamb, goat), specific seafood (shrimp, scallops, cod, sole, oysters, mussels, clams), pasture raised eggs, very lean 99% chicken/ turkey/ fowl (These are very lean because they are high in polyunsaturated fats if not).” I am older and active to I try to get 1g/lb. Like I mentioned in an earlier post when I dropped the protein intake below that my recovery suffered but that was with lower carbs so now that I am increasing them I will adjust and see how it works. I only track animal based protein in crono and disregard the plant based. @Jennifer said in Protein synthesis / net carbs: Since you developed allergies and digestive issues following a keto(ish) elimination diet and feel better since upping your carbs, I wonder if your thyroid was affected. Have you tracked your temps and pulse rate first thing in the morning and 20–30 minutes after eating? Too much protein relative to your needs and not enough carbs can lower thyroid function, and poor thyroid function is a common cause of allergies. I never had any thyroid problems until I did the lower carb diet. I did lab work while I was on that diet and my free T3 crashed but as soon as I increased the carbs it came right back to upper levels and that was just around 120 carbs. Definitely affected my thyroid. Unfortunately I had food allergies before starting that diet. I have had to avoid shell fish for quite some time now. But the EoE and possibly related to dairy/eggs could be the supps she has me on or my gut is now so messed up that will be need to be corrected. Would be nice if it was one of the supplements. Good thing is I am rotating off of some of the supps she has had me on for a year now and that is in the time frame EoE appeared. Something I will need to watch, thanks.
  • oxidised fish oil experiment

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    Milk DestroyerM
    @the-MOUSE That does seem to be what a couple of people that did hardcore Peating are saying. I can't say whether it is or not as the only time I was supplementing with lots of omega-3 was when I was also on a shit diet and the omega-3 didn't seem to help the shit diet.
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    DavidPSD
    The Multifaceted Roles of Proline in Cell Behavior Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino acid is: (i) A main precursor of extracellular collagens (the most abundant human proteins), antimicrobial peptides (involved in innate immunity), salivary proteins (astringency, teeth health) and cornifins (skin permeability); (ii) an energy source for pathogenic bacteria, protozoan parasites, and metastatic cancer cells, which engage in extracellular-protein degradation to invade their host; (iii) an antistress molecule (an osmolyte and chemical chaperone) helpful against various potential harms (UV radiation, drought/salinity, heavy metals, reactive oxygen species); (iv) a neural metabotoxin associated with schizophrenia; (v) a modulator of cell signaling pathways such as the amino acid stress response and extracellular signal-related kinase pathway; (vi) an epigenetic modifier able to promote DNA and histone hypermethylation; (vii) an inducer of proliferation of stem and tumor cells; and (viii) a modulator of cell morphology and migration/invasiveness. We highlight how proline metabolism impacts beneficial tissue regeneration, but also contributes to the progression of devastating pathologies such as fibrosis and metastatic cancer.
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  • Best Soda?

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    Ray Van WinkleR
    Wallmart has jarritos now, i get it delivered every week
  • Does t3 reduce facial bloating?

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    @PrinceTrebata This morning I was 97.1 with 60 pulse. I tend to wake up a bit puffy, feet kinda swole feeling, face lacking color like not much circulation, bit stuffy nosed. I was 99.2 the evening before this. After eating and little walk I get my metabolism and temps back up to a good level and feel good. I’ve been over the adrenaline hump since ramping up to this dose over the past few months taking it slow this time. I’ve never done any blood tests but I take vitamin D daily
  • Struggling on the Ray Peat Diet?

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    I couldn't do average grocery store orange juice from unripe oranges. I don't tolerate oranges well in general. No problem with sugar and milk though. The ideal Ray Peat diet is cherimoyas and gelatin, lobster and Italian cheese as he said in the back of a tiger interview. Milk and orange juice are least bad while economical. Orange juice instead of whole oranges cause Ray had an allergy to orange fiber.
  • Slight pain when supplementing TUDCA

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    PrinceTrebataP
    @irs I don't know how effective TUDCA really is. I know low ratio of t4/t3 around 1/1 2/1 is good for the liver and would help your hypothyroidism. Coffee is generally recommend by peat as well. Fatty liver is a pretty serious issue and while TUDCA may help I don't think it will solve it.
  • Potatoes causing skin issues

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