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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    543 Topics
    4k Posts
    LucHL
    @DavidPS said in Lipofuscin accumulation in aging and neurodegeneration: Dr. Peat has written about lipofuscin. Too many options (lazy). here I've got this info on my pC. *) How the Oils In Your Diet Are Aging Your Skin. Dr. Peat goes on to explain what this rancidity (oxidation process) does: "The free radicals produced in this process react with parts of cells, such as molecules of DNA and protein, and may become attached to those molecules, causing abnormalities of structure and function." https://raypeat.com/articles/articles/unsaturated-oils.shtml EGCG Inhibited Lipofuscin Formation Based on Intercepting Amyloidogenic β-Sheet-Rich Structure Conversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816542/ "Lipofuscin (LF) is formed during lipid peroxidation and sugar glycosylation by carbonyl-amino crosslinks with biomacrolecules, and accumulates slowly within postmitotic cells. The environmental pollution, modern dietary culture and lifestyle changes have been found to be the major sources of reactive carbonyl compounds in vivo. Irreversible carbonyl-amino crosslinks induced by carbonyl stress are essentially toxiferous for aging-related functional losses in modern society. Results show that (-)-epigallocatechin gallate (EGCG), the main polyphenol in green tea, can neutralize the carbonyl-amino cross-linking reaction and inhibit LF formation, but the underlying mechanism is unknown."

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    61 Topics
    696 Posts
    yerragY
    @what-about-bob Thanks. I like the summary. How everything all fits in from theae great minds and put together by Ray Peat into more practical lifestyle applicable ideas. I am appreciating how I see myself on the "applied technology" end of their contributions as I incorporate these ideas into my attempt to be my own doctor as I attempt to improve my health. I have been unable for the past 24 years to lower my blood pressure without using prescription medication. But I am seeing the light at the end of this tunnel. It is a long process of learning and I don't give up. Thanks to recent developments in science and technology, I may be able to lower my blood pressure finally using ideas from Peat and his predecessors. What has been helpful is my use of AI as an efficient research assistant and aggregator of concepts and minute details that my own limited human mind can't recall easily and utilize readily.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    10k Posts
    S
    ^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    360 Topics
    3k Posts
    alfredoolivasA
    @engineer @engineer said in Separation in Pansterone bottle: Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study oh my, if what you're saying is true, then Georgi made a major oversight with how common precipitation seems to be judging by other reports on RPF. You are coming close to taking the Peat black pill. We welcome you

  • Recipes, food, meal prep, brands. Discuss them all here.

    226 Topics
    1k Posts
    alfredoolivasA
    @heyman said in Euphoric foods: äggost Does it taste like cream cheese?

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    85 Topics
    1k Posts
    BioEclecticB
    @jamezb46 said in pre workout / intra / post workout: @BioEclectic Why do you think lactic acid produces DOMS? From what i had read at the old RPF forum, though i always hold open the possibility that i have either misconstrued or misremembered whatever i had read. Not sure if this applies but I do know it noticeably reduces work or shoe related foot soreness. Mag sulfate and Mag bicarbonate.
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  • SugarS

    Why is raypeatforum so touchy about the topic of looks, becoming more attractive, and height?

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    yerragY
    @NoeticJuice said in Why is raypeatforum so touchy about the topic of looks, becoming more attractive, and height?: I don't like narcissists but I don't judge them (in terms of right and wrong) for being narcissistic. There are reasons for why they are the way they are and they couldn't at that moment be any other way. If I know a person is a narcissist I would avoid them because being near them is likely to be harmful to me Judging is so taboo in western culture. Saying I don't judge is just a way of fitting in to the norms of society, but in action we can see people judging even as they deny so in words. When you say you avoid being with narcissists, were you saying there is no judgment on your part? But the rest I won't need to rebut. We both make arguments that can stand on their own weight. It's good we made our point heard. The divide is real between us. I would even say irreconcilable. All of this is subjective, and that outcome is expected in subjective matters. Hope to see more agreement as we share ideas on bioenergetics.
  • _

    Sleep Issues - Please Help

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    herayclitusH
    @Insomniac Yes, it's best to cycle on/off every few weeks and stick to the lowest effective dosage. I usually do 2-5mg maximum
  • W

    Help me with a pro-metabolic protein drink with lesser known ingredients

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    M
    @wester130 said in Help me with a pro-metabolic protein drink with lesser known ingredients: @Mulloch94 would dissolving the bcaa in orange juice mask the taste? Maybe, I find the bcaas to be bitter. My shake with milk, blueberries, bcaa, and honey (recently omitted bananas) tastes really good. So I know that combination works. It doesn't work in oatbran though, very bad, lol.
  • S

    Dr John McDougall dead age 77

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    M
    @Insomniac said in Dr John McDougall dead age 77: @Mulloch94 The community knows exactly what happened here. It was the sweet potatoes. Killed by carotanemia and/or hypervitaminosis A Haha, dude was looking a little orangey wasn't he Edit: To be entirely fair and not make a complete spectacle of their views, it is reasonable to believe McDougall viewed carotene as a good thing. I don't know enough about him to confirm this as the case, but considering he was against animal forms of vitamin A it almost forces his hand here. Nevertheless, his wasting seemed to be a big driver to the decline of his health, just from a pure visual look at least.
  • W

    let's create the perfect T supplement

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    W
    @jamezb46 nothing - I meant increase the vitamin E/olive oil to 90% and make the rest 10% Food Grade Ethanol Now foods Vitamin E is 95% vitamin E/5% Olive oil "The Vitamin E content is >95% and the balance is olive oil. Wishing you good health, Jim G. NOW Product Information Dept."
  • b1B

    How to bioenergetically shoot bigger loads

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    V
    Anything that increases androgens and lowers stress hormones. In my experience when I have increased androgens using DHEA and Progesterone combined with Androsterone it greatly increased volume. Also try to refrain from ejaculating for a few days and you will notice a big difference. Cistance I also found to be very powerful.
  • AlphaZanceA

    Heat Shock Proteins & HSP70 + Factors That Increase Them

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  • M

    No craving for protein, only carbs

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    M
    @Norwegian-Mugabe thankyou. I'll try 140g maximum.
  • SugarS

    What is the most effective protocol for young men to looksmax?

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    L
    @Norwegian-Mugabe thanks!
  • cs3000C

    Bag breathing can fix hiccups (co2)

    hiccups co2 bag breathing
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  • cs3000C

    Effect of co2 in healing chronic wounds (human studies) (gas vs foot bath)

    wound ulcer co2 healing chronic
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  • SugarS

    Bioenergetic stack for a fight?

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    B
    Thank you. I made a note. Thank you.
  • S

    Vitamin B6 supplement makes me feel great, why? Safe for long-term use?

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    ?
    @Mauritio If high dosing thiamine, also watch out for magnesium issues, potassium (I rely on OJ), zinc, riboflavin (yes!).
  • the MOUSET

    toxic heavy metals everyhwere

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    yerragY
    @AkJono Thanks!
  • C

    Reducing/eliminating myopia

    eyes
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    W
    the problem is - who has time to do this? The eye habits would interfere with your entire life, driving etc You could only do the eye habits in your spare time
  • S

    Anyone use xylitol mints

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  • ?

    region with the least bad people

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    R
    @LetTheRedeemed
  • SugarS

    Why are women today, the non fat ones, better looking than women back then?

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    I
    @insufferable said in Why are women today, the non fat ones, better looking than women back then?: I don't think it's makeup, the generations really do look different. I don't know why. I think I remember a study that identified how skull shapes (within the same ethnicity) are changing over the last 100 years, but I can't find it. Just found something: https://news.utk.edu/2012/05/30/american-heads-getting-larger/ https://pubmed.ncbi.nlm.nih.gov/27737575/ Skulls have gotten higher, narrower, longer, and larger apparently. You can look at old pictures, compare them to modern ones, and you can see the narrower and longer change. I noticed it many years ago looking at old pictures. I guess it's happening for the same reason people are getting taller, this is the same phenomenon happening to the skull. @Crimkadid on twitter talks about stuff like this a lot.
  • L

    Ideas for knocking out "hidden" lymphatic bacterial infection

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    yerragY
    @Regina you know the human condition hexed by ideas like love thy enemy and take up your cross lol
  • HyperTorlessH

    Kidney general

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    HyperTorlessH
    Hello everyone, let's talk about: Apple cider vinegar Adding 1 tbsp to a glass of water (preferably filtered or naturally sourced) appears to be an insane lindy trick. Remember our ancestors mostly drank lightly alcoholic beverages (light beers or wine or posca) throughout the day, to rid of the parasites in untreated water. According to Dr Eric Berg, ACV : helps break oxalate dissolves kidney stones (by breaking calcium compounds) helps retain potassium other little things While I'm unsure about the mechanism, I trust Dr Eric Berg that it's a simple and easy way to make a change for the better regarding kidney health. See his channel for the whole case: https://youtube.com/@Drberg/search?query=apple vinegar I am currently testing it to ease out kidney pain in the morning, and I believe it's working -- but I'll report more later. Intense summer heat has me being less optimally hydrated than usual. I'm doing 1L of water with 1-2 tbsp of ACV.