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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    Z
    @AlphaZance said: @ZackVegas Correlation isn't causation. Did you think that in one hundred years the only factor affecting public health is PUFA? Of course the increase in PUFA isn't the only factor. There was also a massive spike in iron intake, which is also problematic, for example. There's lots of other things, from drugs to stress to quality of food that go into any long term trend. And high PUFA oils do lead to lower quality foods. Chips fried in beef tallow only have 3 ingredients.... Potatoes, Tallow, and Salt. Chips fried in high PUFA seed oils require a host of preservatives and antioxidants, due to the instability of PUFA, as compared to saturated fats. Yes, correlation isn't causation, but PUFA is very obviously a key driving factor in the rise of obesity. We know that large amounts of PUFA slow down metabolism, and fatten animals. We know that it takes extra steps to process in Beta Oxidation than Saturated Fats, Monounsaturated Fats, or Trans Fats (that is just textbook biochemistry). We know that Omega 6 is inflammatory. And we have seen that removing PUFA in fat free diets increases metabolism, and can even cause weight loss in humans at what is thought to be a maintenence level of calories. This is from the link your provided: "Decrease in the unsaturated fatty acids as a result of the low-fat regimen indicates the probability that even the normal adult human subject, like the rat, is unable to fabricate the highly unsaturated fatty acids, which should, therefore, be provided in the diet. In the light of this latter observation, it cannot be assumed that the human subject could subsist indefinitely on a diet completely devoid of the unsaturated fatty acids." Yes, it does. But so what? The study itself showed that a human could not just survive, but significantly improve his health on a 6 month diet devoid of unsaturated fats. The whole idea that something labeled "essential" has to be something that the body can't produce is pretty silly. For example, if blood glucose drops too low, coma and death will be the result. Yet for some reason, glucose isn't considered "essential" because the body can generate it from protein so that coma and death don't result. Again, the only issue ever mentioned from so called "Essential Fatty Acid Deficiency" is skin problems, like scaly tail in rats, or rashes or xerosis in humans. I've cited Omega-9 made from de nuovo lipogenesis doesn't build lipid bilayers effectively. Also, research on diets high in saturated fats is that they increase transepidermal water loss (TEWL). Don't know what studies you are referring to here, but often times, those study diets that are 'high" in saturated fat are often higher in PUFA and unsaturated fats in general. If the study used a purified diet with HCO, that would be about the only diet that contains fat with next to no PUFA, and that regiment would have to go a long way to ensure the proper vitamins and minerals that you would get from something like milkfat or beef fat in normally eaten foods.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    LucHL
    OK, I didn't know precisely what you knew, excpt I could have guessed I understand better now. I didn’t handle 5-HT receptors very well, outside from the serotonin recapture and side effects, when targeting 5-HT1. After a search, to try to help you, here is what I get. 5-HT3: Target: The "Spasmodics" (Digestive system & Rejection reflex) So you try to avoid to stimulate 5-HT3 (Nausea, reflux, intestinal spasms, accelerated transit), hoping to dampen its action (to get calm digestion, intestinal anti-inflammatory action). Neutral impact on alertness. 5-HT2: You are looking to block them (specifically 5-HT2A and 5-HT2C). They are at the heart of the bioenergetic stress cascade. Main 5-HT receptor you need to avoid to stimulate when serotonin level is high, with inflammation, anxiety and / or insomnia. This is where a selective blocker is needed. => Your main target. Neutral if selective (Drowsiness if combined with an antihistamine). 5-HT1: Central brake. It is the thermostat (especially 5-HT1A) that prevents the system from overheating in terms of serotonin. Comment (LucH): As I can see, there are side-effects from mirtazapine Excerpt: If the goal is a stronger prescription medication that mirrors cyproheptadine's specific serotonin-blocking mechanism, mirtazapine is a tetracyclic antidepressant that acts as a potent antagonist at 5-HT2 and 5-HT3 receptors. It is highly sedating and increases appetite, so it shares similar side effects but is used clinically for mood and sleep regulation. [1] Source: https://www.drugs.com/compare/cyproheptadine-vs-mirtazapine Here are some pieces of advice, for general purpose and other readers There is an interaction through the HPA and HPT axis from LPS toxins. Impaired alternation between the sympathetic and parasympathetic modes. LPS endotoxins activate the HPA and HPT axes, disrupting the balance between the sympathetic and parasympathetic systems. This lack of autonomic alternation locks the body into an "alert" state, leading first to cortisol dysregulation and subsequently to a chronic inflammatory cascade. NB: Not only from LPS toxins of course. Impact from the vagal nerve on the HPA and HPT axis. Over-the-Counter & Herbal Alternatives If you are looking for non-prescription options that modulate cortisol or provide a similar calming, anti-stress effect, consider these: • Magnolia Bark (Honokiol & Magnolol): This is one of the closest natural alternatives for cortisol management. It acts as a mild GABA-A modulator to reduce anxiety and actively helps lower elevated cortisol levels without the severe drowsiness of cyproheptadine. [1] https://restorativemedicine.org/digest/natural-neurotransmitter-support-practical-guide-botanical-psychiatry/ • L-Theanine: An amino acid found in green tea that promotes alpha brain waves, elevating calming neurotransmitters like GABA and dopamine. It helps blunt the physical stress response and lowers stress-induced heart rate spikes without inducing lethargy. [1, 2] https://bioenergetic.forum/topic/9559/cyproheptadine-anti-stress-alternatives https://restorativemedicine.org/digest/natural-neurotransmitter-support-practical-guide-botanical-psychiatry/ • Ashwagandha: A widely studied adaptogen that regulates the hypothalamic-pituitary-adrenal (HPA) axis. It is highly effective at reducing baseline cortisol and mitigating chronic stress. [3] 3. https://www.mindlabpro.com/blogs/nootropics/serotonin-herbs • Magnesium Bisglycinate: Magnesium is heavily depleted by stress. The bisglycinate form crosses the blood-brain barrier effectively, acting as an NMDA receptor antagonist to calm over-excitation in the central nervous system. [1] I would associate B6 with Mg bisglycinate, and maybe taurine if present. Hope it could help. For the average reader: Here is a simplified overview of the serotonergic system to help you understand how these receptors influence immunity, digestive transit, alertness, and mood. Serotonin (5-HT) acts like a key, while the receptors (ranging from 5-HT1 to 5-HT7) function as the locks. Depending on which lock is activated, the biological effect can be radically different—or even completely opposite. In other words: the dosage and duration of treatment should be adjusted based on how you feel. It may be necessary to alternate your approach—again, based on how you feel—to allow your system to "recharge its batteries" (...)
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    alfredoolivasA
    @Meursault this is an easy finesse stay safe nigga
  • Recipes, food, meal prep, brands. Discuss them all here.

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    zeitgeistZ
    @sunsunsun There are hundreds of studies on the benefits of PUFAs and the unhealthiness of saturated fats. The same goes for fiber, serotonin, “T4 supplementation is enough” and many more core pillars or antipillars of bioenergetics. If you argue that Peat came to the opposite conclusion which the study claimed, provide a source. The magnesium argument is unsound, I explained the antinutrient role of phytic acid - oatmeals deplete magnesium, not increase it. I also made the effort to go through the famous pro-oatmeals studies you mentioned and explained why their approach in conducting research is wrong, you did not refute any of that, only simply said that Ray made mistakes as well (without offering any examples). Also, it is not a cope, I thoroughly explained my disagrement with the studies, the one who is dismissive is you. They are filling, sure - but if the world offers better alternatives, why stick with a suboptimal option? I am not saying they are poisonous, like in the case of nuts (which are also often recommended for hiking and considered healthy overall). The way in which I interact with this forum is to find the best available methods, substances or foods to better my health, productivity and happiness. Sure, if the only option were oatmeals, I would say take the oatmeals. That however, is not the case. We do not live in a severely starving society, at least I hope so. We have access to some of the greatest resources on health available, our options with potential remedies that are to our disposal are endless. Why stick with the flawed when the possibilities are limitless? We shall strive for new heights, remain cautious of becoming prideful, but otherwise try to do things which were thought impossible before. With such a mindset that you seem to endorse, you limit yourself to the paths available.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @wester130 I just do the medium high seat biking due to convinience. Should be higher tbh.
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    the MOUSET
    @yerrag i see tyvm. no idea citrate had that risk, just thought as its pre cheap n alternative to bicarb n can hyrdrate siumilar to fruits
  • Anabolic steroids can cause severe anxiety

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    @Insomniac it's super stimulating and makes sleep very light in my experience, in high doses. at the right dose it probably just feels good. but these guys take retardo dosages
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  • Inducing metabolic syndrome in a healthy person

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    @ThinPicking Yeah I'm thinking acidic water with some phosphoric acid, NaH2PO4 and a good amount of fructose. HFCS is notorious for this. Maybe some tryptophan, methionine, cysteine too. Gonna have to look up solubility
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    AmazoniacA
    A cohort of cancer patients with no reported cases of SARS-CoV-2 infection : the possible preventive role of Methylene Blue [image: 1718754397059-4e314a2e-2445-4e94-bfd9-2ad2a5b2f9a6-image.png]
  • Peating has done nothing but make most symptoms worse intensity wise

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    yerragY
    @GreekDemiGod I can say that PUFA was the major change that had the most impact on me. I was very strict on it, considering as poison actually. But years prior to PUFA restriction, I had all my mercury amalgams replaced and after that underwent IV chelation to rid my body of mercury toxicity. What this did was to improve my tissue oxygenation, so I won't be hypoxic and relying on anaerobic glycolysis for energy production. I was making a lot if lactic acid instead of CO2.
  • Narcissists - what causes it?

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    labelling people of varying disposition as narcs is kinda dumb at some point
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    @Verdad https://raypeatforum.com/community/threads/why-is-this-serotonin-receptor-type-bad.25497/ "there is a difference between plasma and platelet serotonin, and it's my understanding the 5HT2B is plasma, which is the very bad serotonin" by user alywest and then https://raypeatforum.com/community/threads/vitamin-k-and-other-naphthoquines-are-pro-dopamine-and-anti-serotonin.21548/ "1,4-naphthoquinones stimulate serotonin uptake in platelets in a manner similar to other SSRE such as tianeptine and in opposition to SSRI drugs like Prozac (fluoxetine)." by user haidut So it seems like a good effect
  • What do you think about the raw milk only crowd on social media?

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    SugarS
    @Mallard6146 Have you tried some of the organic grass fed pasteurized brands? Raw milk is definitely miles better than conventional store milk, and I've had the same brain fog sick feeling after drinking too much conventional store milk, but I don't get that from organic pasteurized.
  • NAD Infusion Alternatives

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    jamezb46J
    @basebolt Perhaps it would be worth looking into eye drops with NAD+? You would try dissolving raw NAD+ powder into a super saturated yet eye safe solution, and putting a few drops in each eye. Benefits would be felt in the brain the quickest, due to law of locality.
  • Crave milk after eating

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    Norwegian MugabeN
    I always need milk after eating meat. This seems to be fairly common.
  • Chronic nocturia: Advice?

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    NotShanalotteN
    @mavuue It can take up to a week for the kidneys to adapt to the different salt levels. If need be, note the amounts you had before and after my advice, and escalate towards the higher value to make the transition easier.
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    NotShanalotteN
    @Verdad I didn't notice any, but she did. FWIW as I healed I had heart palpitations from nearly everything that has a healing effect, calcium, vitamin D, preg, progesterone, DHEA, the list goes on.
  • Sun exposure

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    I read somewhere that 15 minutes of direct mid-day sunlight on a patch of fair skin will produce maximum vitamin D, more doesn't accomplish anything. You can get hours of sun outside of tanning/burning hours though (10am-4pm during standard time, which is 11am-5pm during daylight savings time)
  • Grow oranges in the snow

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    LetTheRedeemedL
    @Cicero Yo thanks for bumping your post. this is the coolest ever. Composting is another unexpected way to generate serious heat for greenhouses https://www.youtube.com/watch?v=AjHIwabtqGo
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    cs3000C
    @Mauritio it gave them baseball nuts lol . reminds me of that study where they gave rodents a bacteria from an olympian and it gave them superpowers yeh proinflammatory as usual way for immune system to eliminate fungus according to op study. i tried reuteri a while back, think it was the strain that starts with 6 , took it with glucose. i wrote in notes "good to feed with glucose but lactose boosts reuterin production more". but i didnt notice any changes for energy mood or inflammation, but wasnt trying for low test specifically @tea nice the riboflavin checks out , great study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9927497/ 1mg/kg i.p , shows it reduced a lot on the tongue and more in kidneys. i think u can absorb up to ~30mg orally [image: 1718019507648-9a07a302-7a25-4c80-8df1-8938d062102b-image.png] Interestingly it stopped the fungus transporting & processing carbs/sugar , pyruvate accumulated
  • Best source of thyroid in the Netherlands?

    thyroid hormone supplements
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  • Effect of endocrine disruptors on females?

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    Hando-JinH
    endometriosis and PCOS and very common now borderline personality disorders and similar pathological behaviors also seem to be becoming more common in women
  • Creatine and Ray Peat

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    @yerrag said in Creatine and Ray Peat: @mostlylurking I think (I have not been reading a lot lately so I could be wrong) that anaerobic glycolysis is wasteful of thiamine, and that thiamine mega dosing helps, but clearing the capillaries of obstruction to make oxygen available to the brain fully is the way to fixing Parkinson's. Thiamine megadosing helps by compensating for the inefficiency and wastefulness of anaerobic glycolysis. Hi yerrag, thanks for the link; I always value your insight. I read through your post and immediately thought of a Ray Peat audio when he discusses vitamin K2 for removing calcium in the circulatory system. I believe my own thiamine deficiency/functional blockage fall of 2020 derailed my calcium storage which usually means the calcium that is supposed to get stored in the bones gets stored in the soft tissue (including the blood vessels) instead. Peat related a story about a doctor he knew that used high dose K2 (40-50mgs?) to resolve his hypertension. Thiamine is needed for good oxidative metabolism. When it is deficient, the end product of the process is lactic acid instead of carbon dioxide. If things are working right, the carbon dioxide drags the calcium inside the cell out when the carbon dioxide exits the cell (from memory - A Peat explanation from somewhere). So it makes sense that calcium storage would get derailed in a thiamine deficiency. Here's a link or two: https://bioenergetic.life/?q=k2 The one with the story about the doctor high dosing the K is in there somewhere.... also this:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926526/ Please note that vitamin D, needed for the immune system to work, also is responsible for making calcium get stored in the bones; in order to do this, there needs to be vitamin K available. So I think both D and K would be helpful.
  • topical ATP supplement helping me regrow hair

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    @wester130 In response to the man advising to use bio estro cream I think it works by causing vasodilation https://en.wikipedia.org/wiki/Vasodilation There are better ways to increase vasodilation to the scalp