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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    543 Topics
    4k Posts
    LucHL
    @DavidPS said in Lipofuscin accumulation in aging and neurodegeneration: Dr. Peat has written about lipofuscin. Too many options (lazy). here I've got this info on my pC. *) How the Oils In Your Diet Are Aging Your Skin. Dr. Peat goes on to explain what this rancidity (oxidation process) does: "The free radicals produced in this process react with parts of cells, such as molecules of DNA and protein, and may become attached to those molecules, causing abnormalities of structure and function." https://raypeat.com/articles/articles/unsaturated-oils.shtml EGCG Inhibited Lipofuscin Formation Based on Intercepting Amyloidogenic β-Sheet-Rich Structure Conversion https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816542/ "Lipofuscin (LF) is formed during lipid peroxidation and sugar glycosylation by carbonyl-amino crosslinks with biomacrolecules, and accumulates slowly within postmitotic cells. The environmental pollution, modern dietary culture and lifestyle changes have been found to be the major sources of reactive carbonyl compounds in vivo. Irreversible carbonyl-amino crosslinks induced by carbonyl stress are essentially toxiferous for aging-related functional losses in modern society. Results show that (-)-epigallocatechin gallate (EGCG), the main polyphenol in green tea, can neutralize the carbonyl-amino cross-linking reaction and inhibit LF formation, but the underlying mechanism is unknown."

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    61 Topics
    696 Posts
    yerragY
    @what-about-bob Thanks. I like the summary. How everything all fits in from theae great minds and put together by Ray Peat into more practical lifestyle applicable ideas. I am appreciating how I see myself on the "applied technology" end of their contributions as I incorporate these ideas into my attempt to be my own doctor as I attempt to improve my health. I have been unable for the past 24 years to lower my blood pressure without using prescription medication. But I am seeing the light at the end of this tunnel. It is a long process of learning and I don't give up. Thanks to recent developments in science and technology, I may be able to lower my blood pressure finally using ideas from Peat and his predecessors. What has been helpful is my use of AI as an efficient research assistant and aggregator of concepts and minute details that my own limited human mind can't recall easily and utilize readily.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    10k Posts
    S
    ^^^^what he said. He’s always taking about his labs and dropping some numbers, but I’ve never seen them posted, especially not in a comprehensive fashion. Maybe they’re behind a paywall, I don’t know.

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    360 Topics
    3k Posts
    alfredoolivasA
    @engineer @engineer said in Separation in Pansterone bottle: Saw that, really interesting how 6 keto has had approximately 0 interest since that 50s study oh my, if what you're saying is true, then Georgi made a major oversight with how common precipitation seems to be judging by other reports on RPF. You are coming close to taking the Peat black pill. We welcome you

  • Recipes, food, meal prep, brands. Discuss them all here.

    226 Topics
    1k Posts
    alfredoolivasA
    @heyman said in Euphoric foods: äggost Does it taste like cream cheese?

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    85 Topics
    1k Posts
    BioEclecticB
    @jamezb46 said in pre workout / intra / post workout: @BioEclectic Why do you think lactic acid produces DOMS? From what i had read at the old RPF forum, though i always hold open the possibility that i have either misconstrued or misremembered whatever i had read. Not sure if this applies but I do know it noticeably reduces work or shoe related foot soreness. Mag sulfate and Mag bicarbonate.
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  • E

    Toxic Bile Theory

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    B
    @Insomniac said in Toxic Bile Theory: Just thought I'd mention that In one of Grant Smith's streams he mentioned that even his ex-wife never bought into his ideas and she knows him much better than people paying him for advice. I noted. https://twitter.com/NutriDetect/status/1543574458044014593 Catch a glimpse of where someone's coming from and things may be clearer. https://twitter.com/NutriDetect/status/1778967836079296877 We're all aching in our own way.
  • F

    How to increase testosterone

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    BioEclecticB
    20 best testosterone-boosting diet plan foods. Hans Amato That's one resource.
  • D

    Light Exposure- A Lesser Mentioned Aspect of Bioenergetics

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    I
    I love getting lots of sun! Definitely a key to health.
  • R

    buteyko method

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    J
    I think this kind of breathing comes about naturally with increased CO2 and they are trying to mimic that way of breathing but I think it’s downstream of a good metabolism.
  • W

    Microcrystalline Cellulose in supplements

    adsorption
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    I find that the fewer supplements I take, the better I feel.
  • T

    Soy-free Vitamin E derived from soy - do you think this matters ?

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    @temple-of-salt I do not. I think there are compounds such as policosanols in wheat germ derived products such as Tocovit. Tocovit from Idea Labs is the best vitamin E product available today.
  • F

    thyroxine troubleshooting

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    F
    so essentially : porcine NDT with meals - raise only T3/FT3 to the optimal levels and my FT4/T4 drop to bottom and all severe symptoms appear. Raising only t3 levels helps only a bit with symptoms. taking T4 (on empty) and some NDT(with meals) - i see major improvements for some time before rt3 builds up and blocks metabolism and causes accumulation of the supplemental hormones to high levels in the serum.
  • P

    Why does cupping work?

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  • the MOUSET

    thoughts on taking mk677?

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    M
    @the-MOUSE Keto diet would probably make it worse. Growth Hormone increases free fatty acids, and adding that on top of ketosis will just augment it further. Taking it with B1, B3, and B7 might reduce it's negative effects. Just make sure you keep eating carbohydrate, because that b-vitamin stack could cause hypoglycemia.
  • D

    Fornication, Fraud, Foolishness, Faggotry, and Fapping are anti-metabolic.

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    C
    @Tahodama you still produce semen anyways even if you abstain and don't "reproduce" so the net energy investment into sexual function is more or less consistent most of the time independent of sexual activity levels hence why if you were to not ejaculate for a week you'd expel a higher volume of semen as your body keeps the process going independent of your engagement in it also why the nofap/semen retention claims that the commonly associated symptoms with post-ejaculation are due to sexual energy or semen loss is BS it's more to do with inflammation from prostaglandin release many have healed those downsides by Peating and/or anti-gut inflammation diets like carnivore
  • F

    Mikes healing corner.

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    E
    Lately I’ve been wondering if when stress hormones are high, and thyroid is supplemented, if it’s possible there’s a “grace period” where stress hormones are high, AND the supplemental thyroid combine for people experiencing wellness. Then, as the thyroid supplementation continues, the stress hormones drop and the net energy seems “lower” due to the lack of stress hormones with the supplemental thyroid. I think the solution is to continue thyroid supplementation and increase it as Peat recommends, (half a grain every two weeks). I can’t tell you how many time I’ve seen people take pro-metabolic substances, get a fantastic initial reaction, and then their previous symptoms return. At which point, they give up, or move on to another substance and repeat the process. This is exactly what happened to me too when I first began trying to incorporate Peat’s work. Not saying it’s what happening to you, but just something I’ve seen many times.
  • P

    This topic is deleted!

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  • cs3000C

    Sleep apnea cured in 2 months with either progesterone or thyroid (study)

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  • hwisdomH

    Burned egg shells bad?

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    M
    You burned the shit out of them if they're black, lol. But the cal carbonate is still probably okay. For future reference, I find saving the shells from boiled eggs to be the best. The boiling sterilizes them in the cooking process, so no need to reboil them. Just make like a big bowl of eggsalad or something to eat on for the week and you've instantly got a new batch of shells ready to be ground. You can let them air dry for a day before grinding them if you're worried about burning them in the oven.
  • wolfyW

    How do you get rid of hay fever?

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    ?
    Try checking some of the excipients in any supplements you are taking or perhaps there is something you are eating that may be causing intestinal irritation which can lead to allergic symptoms.
  • wolfyW

    Resting heart rate dropped to 55-60 after peating.

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    wolfyW
    @cs3000 well, I'm almost never cold anymore, and I've been seriously exercising for 8 years now, so I guess I have a big heart, idk I've never measured my heart, not sure how I would.
  • ?

    Nicole Shanahan (VP pick/RFK Jr Independent presidential candidate) talks Bioenergetics, Science, Tech, AI

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    Are There Any Serious Side Effects Associated With Varenicline? | Dealonpill

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  • the MOUSET

    thoughts this article Metabolic Endotoxemia: The Link Between the Chronic Diseases and the Saturated Fats You Want to Avoid

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    ?
    @insufferable said in thoughts this article Metabolic Endotoxemia: The Link Between the Chronic Diseases and the Saturated Fats You Want to Avoid: I remember RPF posts that explained this by saying that saturated fat was actually clearing the endotoxin away or something and was actually good for endotoxin reduction. I don't know. I do know that coconut oil always makes my digestion great. Me too. Ray Peat was a big advocate for coconut oil and saturated fat, but a lower fat diet overall. I watched my father die young of heart disease after following the bad advice of doctors to only eat unsaturated fats after he had a heart attack at an early age. This study was entirely too technical for me, but... [image: 1712378243998-a14ff105-d38f-43f1-a6c7-bb491ef370c9-image.png] https://x.com/ChrisMasterjohn/status/1774506746788065456
  • b4ndsup.mannyB

    Can I ingest topical E oil orally?

    vitamin e
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