@happyhanneke said in Please critique my lab results.: Any comments or thoughts are appreciated. Hi, when modifying the dose, do it progressivity, on a 10 - 15 days period. Cut the dose on every other day. Taking levothyroxine won't solve the problem on long term if you can convert T4 to T3 and FT3. You need useful nutrient for deodinases to help the conversion. + iodine (I2 & potassium iodide) for other organs and tissues. I can develop if desired.

Taking too much progest e at the right time in her cycle can be a contraceptive itself, whereas estrogen is an abortifacient; probably not a great idea to override the body’s workings constantly like this though. Tracking her cycle and going outside ovulation windows can help. I imagine it would still have its positive effects in her current situation but would be better just stopping the birth control and detoxing her liver.

@Ibshaver23 hesperidin from orange juice inhibits TLR4, ferulic acid too

@Norwegian-Mugabe what do you mean exactly by "tits in mind"?

@NARINGENIN another resource for polyphasic sleeping https://polysleep.org/wiki/Main_Page

@jamezb46 said in Need To Figure Out Niacin and NAC Curing Me: Can you link to any studies showing that 500-600mg Niacinamide daily caused any insulin resistance? I'm not going to make this search for 3 reasons: Need time and much energy. The excerpts from the study given by Amazoniac have already given 2 sources on excess B3. You could have been first trying to reach them. Note that the excess B3 must be understood on the long term, not in cure. The studies are not all clear (different conclusions). B3 supplement has an impact on lipogenesis. The time period impact is said to be only for 2 hours. I don't feel it so (I took Kg / Lb weight when taking niacinamide 100 mg). Niacin and niacinamide are said to affect lipolysis differently. In theory. Examples of studies: *) From “Long-term Treatment With Nicotinamide Induces Glucose Intolerance and Skeletal Muscle Lipotoxicity” p4 https://raypeatforum.com/community/threads/long-term-treatment-with-nicotinamide-induces-glucose-intolerance-and-skeletal-muscle-lipotoxicity.15393/post-211103 => It is shown that nicotinamide and oxythiamine inhibit inclusion of C from glucose into free fatty acids, antivitamin intensifies lipolysis in the fatty tissue of the diseased animals." *) Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277745/ NB: Possible adverse effect when taking B3 longer than 1 month. Study Link (given by Amazoniac): https://doi.org/10.1038/hr.2011.133 https://www.nature.com/articles/hr2011133 35. Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, Bian FN, Zhao ZG, Guo M . Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol 2010; 16: 2378–2387. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20480523 Conclusion: The appetite-stimulating effect of nicotinamide appears to involve oxidative stress. Excess niacin consumption may be a major factor in the increased obesity prevalence in US children. => A 3-h blood glucose was significantly lower after co-administration of glucose and 300 mg nicotinamide. The obesity prevalence among American children increased with the increasing per capita niacin consumption, the increasing grain contribution to niacin due to niacin-fortification, and the increasing niacin-fortified ready-to-eat cereal consumption, with a 10-year lag. The regression analyses showed that the obesity prevalence in the US children of all age groups was determined by niacin consumption. 60. Zhou SS, Li D, Sun WP, Guo M, Lun YZ, Zhou YM, Xiao FC, Jing LX, Sun SX, Zhang LB, Luo N, Bian FN, Zou W, Dong LB, Zhao ZG, Li SF, Gong XJ, Yu ZG, Sun CB, Zheng CL, Jiang DJ, Li ZN . Nicotinamide overload may play a role in the development of type 2 diabetes. World J Gastroenterol 2009; 15: 5674–5684. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19960564 Conclusion: These findings suggest that nicotinamide overload, which induced an increase in plasma N(1)-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. => Results: Diabetic subjects had significantly higher plasma N(1)-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects. Decrease in NAD/NADH ratio and increase in H(2)O(2) generation were also observed in human erythrocytes after exposure to N(1)-methylnicotinamide in vitro. Note (LucH): increase in H(2)O(2) = Hydrogen peroxide => ROS = oxidative stress.

@NARINGENIN said in Potential cause(s) for a recurring yeast infection?: Almost no one in the developed world nowadays is iodine deficient. If anything most people get too much iodine from iodinated salt. Ray spoke about this. OK, I see: The Messie has spoken. Sleep well on your two ears. I won't loose time to explain why then. Explanation of RP on this link. Much more to say because there are interpretation biases on this link. Out of context. The Myth of Iodine Deficiency: An Interview with Dr. Ray Peat https://www.functionalps.com/blog/2011/10/12/the-myth-of-iodine-deficiency-an-interview-with-dr-ray-peat/ Posted on Functionalps com (interview reported) References: To Your Health – July 2008 by Lita Lee. https://www.kinesyne.com/wp-content/uploads/2020/02/Thyroid-Resistance.pdf

@LucH thanks for taking a look at this video and commenting on it.

@izkrov Hey thank you for the reply, but I am a bit confused about the nitric oxide boner part. Can you explain what you mean by that?

@16charactersitis I don't see any scenario in which getting more vitamin D and vitamin C (the latter from whole food sources, and the former ideally from light) would be a bad thing. I'm not sure why you're taking a bacteriophage or what your context is but I was just suggesting not to overlook the basics. Glycine is also anti-viral btw. There are more advanced immune-boosting substances like adamantane, but the basics should be met first.

@Mr-X thanks do you mind sharing your dosing protocol and TSH level?

@Hearthfire I think you misunderstand how to work with some varieties of sick patients. That’s ok. Just don’t assume that any part of my comment was ”magical thinking,” I’m speaking in practical contexts… Yeah duh I could’ve gone back to IF and sub 1000 calories a day for a year and lost weight, and my cortisol and estrogenic symptoms would’ve only gotten worse. I had to quit my demanding job because of how sick I had become… there was no practical reason to try losing weight in that context. Sub800 cals on carnivore stopped working for weight loss. This is why my comment you responded to was filled with “practical” Ray himself talked about this. There are obese people consuming 600 cals a day not able to lose weight. I was there. Cortisol and estrogen dominance have real impacts. You go lower in cals for those people and you could be ARE creating catastrophic downline effects. So many systems are beyond f’d at this point that to talk weight loss regime is insulting. Your paradigm is built on studies of cohorts that includes inevitable failure rates with no further inquiry as to why they failed — that is Peats area of expertise, and where I found substantial help to my issues so I could finally lose weight again. In Broda Barnes’ book he notes it’s virtually impossible to lose weight when temps are very low. CICO is Le fail: https://youtu.be/mif1GaSN13A?si=KK-hQPLjJuzwwTYw

@Norwegian-Mugabe said in Random, little things that helped me: A life-changing moment for me was deciding to stop taking advice from older people. You should only listen to youthfull individuals who are masters of fruitful productivity. The stagnant and uninspired should be avoided. So…. Not a Peat stan

@sushi_is_cringe I just want to get bloodwork again soon but they wont put the script in for me unless I do this first. Could go to a third party lab myself but then gotta pay out of pocket.

@goniath, not exactly the same condition but I had chronic gastritis due to SIBO that went untreated for years and what I found helpful was goat’s milk and sipping a tea made from slippery elm bark and marshmallow root (what marshmallows were originally made from) before meals. All three are old remedies for ulcers. If your ulcer is due to H. pylori, goldenseal, a traditional herbal antibiotic, may help but you’ll want to cycle it because of its antimicrobial properties.

@jamezb46 This “deplete PUFA in 30 days” is a pseudo-depletion and would only maintain the result if you didn't eat PUFA and if you didn't access your body fat at great/moderate intensity. What gives fat-free this result is the up-regulation of de novo lipogenesis which dilutes the PUFA as long as the diet is maintained. I have no doubt that the amount of total PUFA decreased, but the fact that a meal replenishes levels almost everywhere already indicates a problem, probably if they put the monkeys in the study on a fast would have the same result depending on the levels of PUFA stored in body fat. When you deplete a rat of PUFA, which has a fast metabolism, it sometimes takes weeks to get it off EFAD (triene:tetraene to <0.4), not one meal. Most studies use a fat-free diet or fat-free + hydrogenated coconut oil diet, but these are not the best diets for accelerating PUFA depletion.

@samson You're getting a huge amount of chlorogenic acid from the blueberries. The same or even more than in the weight loss studies on humans. So that might be part of it, too.

@LucH said in Insulin Resistance, Thyroid, Adrenals or something else?: https://www.youtube.com/watch?v=-Uf1D2KdTn0 Great reminder, thank you!

@peatlegal I assume everyone here or into Peat is a dude for whatever reason. because once you see how profoundly it is possible to shift your way of thinking, living, being, you also see how possible it would have been to do so in the past. Yes, this is hard. It is key to not let this get in the way as it creates regret and guilt. I'm over 30 now so I grasp an idea of vanished time and opportunity. Maybe solutions appear when they need to even though it is frustrating and doesn't happen quickly. Furthermore, God believers say have faith and beg God, but this seems absurd.. the logical end of this is basically going to live in the desert or away from everything and scream at the sky, and be humbled and live as a monk. It is difficult to understand the parts and the whole; for example I think as my beliefs and ideas changed, my view of food and nutrition changed (for better and worse). I don't want to be histrionic but I think that's why Peat is like a very electric author or musician the way he engages people. The modern world is designed like a huge trap a la Kafka. Our cravings are being engineered by R&D teams; raw ingredients long have been subsidized for cheapness/profitability and extreme ideas like anti-starvation, shelf life, and cold war "fallout" shelter rhetoric. Then the FDA and "science" basically helps these big corporations move along calling their products "healthy" because they fortified it, or, because the science underlying all of the assumptions about pufa/grain, etc, is wrongfully concluding it to be healthy too. Outside of nature, the sensations we experience are tied to the worldly materials that have been run through cost analysis resulting in mass production / low quality and engineered to maximize profits regardless of the effects (light, food, sound, etc). It's "revolutionary" pardon the term, to read Peat and others' writings and work on this world's "science," health, etc. Practically speaking, I think without a doubt I used to see "bad" food as a satisfying drug (greasy pizza, fried stuff, booze). Lots of pufa causes hangovers nearly as bad as alcohol, and it was an easy "stress relief" or stress avoidance tactic. The cultural manufacturers prop everything up this way. It's like legal drugs, even though drugs are basically legal now I don't claim to have anything really "worked out" very clearly except trying to understand my place within it a little better. It seems to me all of the mainstays of our "culture" are parasitic and insidious, and part of this is that people don't cook (or produce and create their own life) as much anymore. And institutions and "common sense" people deride people who 1) have energy and 2) think freely. but I can't will that kind of faith into existence. I don't think. It's interesting - I think to some if not many the "faith" in some ways is like asking permission to be and do. As in, I think some people are more confident but lack judgment or introspection. I might understand their faith concept if I was more confident and prideful but lacking judgment. But I spend far more timing thinking and judging things instead of "acting." So I think my faith concept would be in acting and doing. "Ask for forgiveness, not permission." Not my idea, but there's some truth to it.

@Ismail I think I'm making progress. Coffee, gelatin and choline, along with an easily digestible diet high in fructose has, I think, healed my liver to large extent. This, however, didn't solve all my issues, particularly with hypoglycemia. I think the root cause is endotoxin which not only damages the liver, but also leads to extra weight. I think the extra weight I have is actually largely intestinal water weight brought on by frequent cellular excitation, which causes a leaky gut. So now I'm experimenting with high-dose niacinamide to reduce FFAs and increase NAD, and I feel better than I have in a long a time. It's still only been a few days but it feels like meaningful progress. Using this study posted by Haidut as reference. Let me know if you have any tips on improving leaky gut and losing extra water weight, specifically intestinal.