@samson the ribose is not being reduced if it is interacting with MB, it is being oxidized.

I think about this thread once in a while to this day.

@Turk said in Why Does Wine Help with preventing Nighttime urination?: Most nights I have to get up to pee, 1am, 2am, 4am most of the time, but have noticed when I drink wine, usually half or a full bottle, I dont need to wake up to pee. Does anyone know why this helps? For anyone in the future searching for key terms like nocturia, waking to pee, night time urination, wake to pee, etc... When I am not calories restricting and just eating how I feel like, wine and or icecream about 1.5hrs before bed helps me to not pee during the night. And when I'm in a calorie deficit those dont seem to work, but what has worked was taking some cynoplus 1.5hrs before bed, a smaller dose than with my meals, it was about 20mg of cynoplus = 3.75mcg of T3, 15mcg T4.

@winters2 might just be bacteria thriving due to lack of dental hygiene, would repeatedly brush teeth until it no longer stains the toothpaste

@Tarzan17 potatoes are extremely hard to overeat in my experience, maybe just try some potatoes with coconut oil and plenty of salt

Some more information why / when high dose vit E could interfere ... Vitamin K uses the same pathway as Vit E Does vitamin K supplementation deplete vitamin E? Mito says: https://raypeatforum.com/community/threads/does-vitamin-k-supplementation-deplete-vitamin-e.39564/post-622839 There are several aspects of vitamin K’s biochemistry that suggest high doses vitamin K could have adverse effects on our health: • Vitamins E and K are broken down in similar pathways (Shearer, 2008). High doses of either one elicit an increase in these catabolic pathways by activating a common receptor known as the steroid and xenobiotic receptor (SXR) or the pregnane X receptor (PXR). As a result, high doses of one will elicit the destruction of the other. Thus, high-dose vitamin K could contribute to vitamin E deficiency. • Second, a small portion of vitamin K is broken down to a compound known as menadione (Thijssen, 2006). Some of the menadione is used to synthesize MK-4, but high concentrations are toxic. We therefore conjugate a portion of the menadione to glutathione, the master antioxidant and detoxifier of the cell, and excrete the complex into our urine. High doses of vitamin K could therefore deplete glutathione. This would impair detoxification, and along with vitamin E depletion it would hurt antioxidant activity. • High doses of vitamin K can inhibit bone resorption, which is probably the mechanistic basis by which 45 mg/day reduce fracture risk (Iwamoto, 2013). While bone resorption sounds like a bad thing, we need to use it every day to help our bones remodel themselves and adapt their structures to our lifestyles, and to keep blood levels of calcium within a precisely controlled range. We also use bone resorption to release osteocalcin into the blood, where it acts on multiple tissues to improve our metabolic and hormonal health (Ferron, 2007; Oury, 2013). Ironically, one of the benefits of vitamin K2 is to support proper production of osteocalcin, but high doses of the vitamin could hypothetically prevent us from using it. That would be expected to hurt blood sugar control, insulin sensitivity, our metabolic rate, and, in males, testosterone production. https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource

@Chud I knew getting sunlight on my stomach would help with digestion !

@eduardo-crispino I doubt that I heard they are quite potent.

@random Yes this is my third month on 4mg i am still supplementing, first 2 months i was on 2mg.

@ThinPicking Ah I see, for a second I wasn't sure if the Lion switched his fulcrum out from HG7 to some type of giga-soma or something.

@BroJonas thanks for the update

@BroJonas cool. probably should focus on getting pufa out of diet as long as he isn't going to entertain a high carb diet. coconut oil is probably the least bad cooking fat

@Mauritio was referring to you saying you were looking for a peaty practitioner

No need we know. The 'zero spike project' and the 'world council for health' get a shipping container of NAC from chyna and dance around it to the beat of a bongo.

@Quinone I'm not sure. I was about to start a thread on inflammation and bloating. I've been feeling bloated in the morning but after I eat something for lunch I feel much better. I'm suspecting bloating and inflammation are related and linked with stress hormones. But it surprises me I should feel bloated without eating much.

@winters2 said in vitamin E complex?: Didn’t Ray have a negative attitude towards tocotrienols? Yes, but it's a question of dosage and frequency, for me. Still useful, but I won't take much of it, if not in cure, thus for a limited period. Ray said T3 has effects on animal liver (enlargement, probably toxic). T3 is however more fluid / mobile, so that it could easily reach its target (inside membrane vessel, for protection; personal deduction). But I conceive T3 in a rather low fraction, in association with alpha and gamma T1. However there are very few studies analyzing a combo of T1 and T3. And not just under12 weeks as it won't probably prove anything (...) I cite, from "Vitamin E: Estrogen antagonist, energy promoter, and anti-inflammatory" Besides antagonizing some of the end effects of the toxic fatty acids, vitamin E inhibits lipolysis, lowering the concentration of free fatty acids (the opposite of estrogen’s effect), and it also binds to, and inactivates, free fatty acids. The long saturated carbon chain is very important for its full functioning, and this saturated chain might allow it to serve as a substitute for the omega -9 fats, from which the Mead acid is formed. The unsaturated tocotrienols have hardly been tested for the spectrum of true vitamin E activity, and animal studies have suggested that it may be toxic, since it caused liver enlargement. One possibly crucial protective effect of vitamin E against the polyunsaturated fatty acids that hasn't been explored is the direct destruction of linolenic and linoleic acid. It is known that bacterial vitamin E is involved in the saturation of unsaturated fatty acids, and it is also known that intestinal bacteria turn linoleic and linolenic acids into the fully saturated stearic acid.

@winters2 it regulates copper and zinc and makes a “deficiency” in either less consequential