@RayPeatFan said in Vit E and Vit K: Where is the study that claims HD Vit K could contribute to Vit E deficiency? No deficiency but possibly preventing from assimilation. No clear proof. Most studies establish the fact that we should avoid HD vit E (> 300 UI) when taking vitamin K, especially K1. It makes sense (conversion to MK4 more complicated). But that's not this aspect I mentioned. I'm talking about HD MK4 supplement with 400 UI vitamin E. So, studies establishing why or at least mention the advice we shouldn’t take Vit E at the same time as HD K2. Mechanisms according to MG Traber (deduction) https://academic.oup.com/nutritionreviews/article-abstract/66/11/624/1868525?redirectedFrom=fulltext Vitamins E and K appear to share the same metabolic pathways because both undergo side chain ω- hydroxylation and b-oxidation to produce their respective metabolites. Possible mechanisms for the vitamin E and K interaction *) Vitamins E and K share the same metabolic pathways *) Vitamin E competes for the enzyme (yet undiscovered) that truncates the K1 side chain to form menadione; *) Vitamin E increases xenobiotic pathways that increase the metabolism and excretion of all vitamin K forms from the liver; *) Vitamin E competes with K1 for the cytochrome P450 (CYP) that ω-hydroxylates the tail, thereby preventing the b-oxidation of the tail to form menadione. The latter mechanism is hypothetically less likely because, as discussed by Thijssen et al. (11), there is likely to be steric hindrance preventing the complete removal of the K1 side chain via b-oxidation for menadione formation. All of these mechanisms would decrease the production and/or availability of MK-4. The hypothesis that vitamin E interferes with the conversion of K1 to MK-4 is supported by the observations that MK-4 concentrations in extrahepatic tissue are lower in rats fed a high vitamin E diet.

@lobotomize-me If there is a consensus, it is Vitamin A is needed by the body. If there is too much of what is good, it will be bad. Vitamin A is no exception. Why you are here and there is a here is because many of the members here that used to be in the other forum could not stand the authoritarian insistence of its admin that vitamin A is toxic. I personally feel eating liver for retinol, or vitamin A, does wonders that eating the precursor of vit A, beta-carotene (as popularly found in carrots) could not do for me. For eating beef liver once a week for 5 years, my myopia was gone and my driver's license did not require me to wear glasses anymore.

@gg12 Vitamin E is a generic term that encompasses synthetic to natural, single isomer to multi-isomer, to el cheapo useful stuff like the ones find in multi-vitamins like tocopherol acetate. Know your vitamin E.

yeah, I doubt it’s that but my results are quite weird… my body cannot utilize B6 for some reason

@16characterstwas @Tarzan17 &this Post in thread 'Ray Peat Email Advice Depository' https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-882797 Milk and sugar, custard with a minimum of egg (only natural vanilla for flavor), eggs, meat, and sweet ripe orange juice, are the easy things to digest. Even small amounts of plant material can cause inflammation for some people".

@GRay said in mk4 dosing?: egg shell powder egg shell powder is essentially calcium carbonate (+ useful nutrients). We need P to absorb Ca. But not at a meal with HD meat (acid pH 3-4). I won't take Ca supplement if my acid-base balance is fine (K Mg Ca) and P in the lines. I target 850 mg Ca. When I'm under the target like today (450 mg), I add phospho'cal 1.6 g, + 1 half dose Mg bisglycinate to reach my level (+/ 420 mg Mg) (1/2 of 3 g) + 1 big dose potassium bicarbonate (3.2 g). So, no need to be over 550 mg Ca (like the hunter-gatherer tribes in the African savannah. I do / proceed like the reed: Bend (flexibility) but I do not break

I've only gotten weird gut issues with progesterone when taking 30mg+ topical in ethanol per day. And even then, it sorts itself out within 4 to 6 hours. Small doses <12mg/day or so don't have this effect on me.

@CrumblingCookie LOL! I've been observing my stools. They look rather pale and I may not be forming stools with the help of bile. And I have skin itching, and this could be from using Emeramide to detox lead. I suspect it's because the lack of bile is keeping the lead from being excreted thru the fecal route, and it is using my skin as an alternate route for excretion. Perhaps the urinary route can handle only so much.

To continue on the topic @randomname brought up Post in thread 'Ray Peat Email Advice Depository' https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-875276 Q: Thank you Dr.Peat One more question You talked about the negative effects of darkness. So, I was wondering. If someone is a night owl and he spends his night time with a good incandescent light turned on, drinking and eating some sugary stuff, calcium, sodium etc - would the negative effects of darkness be diminished in any way? RP: Yes, even intermittent bright light can reduce the damage.

low fat high carb diet probably.

I've overdone thyroid before and the nerve-damage type symptoms will go away and you will recover. Some thiamine, niacinamide, and a couple months of decent eating and rest and you should be back to normal.

@jamezb46 do you take gelatin (oxtail, wings, shanks, jello, Great Lakes gelatin,..) along with the meat to help balance out the aminos?

@happyhanneke ok . I see. Then maybe some brewers’ yeast sprinkled on morning cereal and or in soup salad or stews will help add needed b vitamins in a naturally concentrated and tasty way. It can also add flavor microwaved popcorn. I like the solgar brand. [image: 1750637354825-5daa17ac-f6d6-4705-9042-d2c2151845c4-image.jpeg]

@Mauritio so, I actually have one version of that, and tried that in camphosal, and I couldn't tell what disolved or didn't, as it also has niacinamide in it... I didn't see any significant improvement in my tongue, but it could've been due to the small amount I used as I was nervous about it actually working before I used all my camphosal (alternatively, could camphosal expire after 8 months after the date on the bottle?)... I wonder if "cuprous nicotinic acid" dissolves in camphosal, just like regular copper.

@CrumblingCookie said This means that stimulating synthesis of CoA and CoA-Ac will strongly increase histone acetylation. Which should be a complement (or beginner's alternative) to inhibiting histone deacetylation (HDACi). https://pmc.ncbi.nlm.nih.gov/articles/PMC3377114/ decreased acetylation of these proteins is associated with an impaired DNA damage response, decreased locomotor function and decreased survival. Decreased protein acetylation and the concurrent phenotypes are partly rescued by pantethine and HDAC inhibitors Wrt to cancer there actually seems to be some specific merit to inhibiting CoA availability in lung and breast cancers, where the SMVT appears significantly upregulated, effectively supplying the tumorous cells with increased supplies of biotin (and pantothenic acid), promoting cell survival and proliferation (which we would like to see more of in non-tumorous but of course not in tumorous tissues).

@yzzy I didn't want to assume their gender

@DakotaWorrell You will never, ever be able to "figure this out". We all have different diet histories, activity levels, etc. I think that as long as you're staying well under known toxic doses, you feel good, and you have some degree of balance between nutrients that are known to interact (ex. vitamin d, k,a; phosphorous:calcium, protein:carbs), that's about the best you can do.

thyroid hormone is dosed and micrograms and iirc is sensitive to light

@PrinceTrebata yes I remember ray saying that. I also recall that he said a small amount of progesterone combined with a little dhea (for example 8mg p4 with one mg dhea) would have a similar effect as pregnenolone would have: https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/page-47

@Meursault consider the possibility the cause @Meursault said in Wisdom tooth causing infection: @Chud the dentist suspected the infection had started 2 months ago which was a time when I was suffering from a build-up of the effects of chronic stress and inflammation. Cascara basically fixed my digestive issues and so I'll try that again along with carrot salad. one thing I am concerned about is the antibiotic treatment worsening gut health in some way. One thing I have noticed on the antibiotics is a very bad histamine response. I already had an issue with this and cyproheptadine makes it better but hasn't fixed the root cause. I suspect impaired liver function and lack of bowel movements, endotoxin as you mentioned is implicated in this. Read that Ray peat recommended taking sugar with amoxicillin to someone who had similar reaction as it is an anti-histamine. I'll try everything you mentioned, I imagine a lot of it will be important in maintaining a lack of any bacteria exposure to the gums that were affected once done with the antibiotics Consider that “worsening gut health“ might be that the amox standard dosage, if that’s what you’re taking, is too high/too toxic.