Thyroid and microbiote Does the thyroid impact the microbiome? (Conversation with Google IA) Yes, the thyroid gland and the gut microbiome have a reciprocal relationship, meaning they influence each other. Thyroid hormones can affect the composition and function of the gut microbiome, and conversely, the gut microbiome can impact thyroid hormone synthesis and metabolism. How Thyroid Impacts Gut Microbiota? Altered Gut Microbiota Composition: Studies have shown that thyroid disorders, such as hypothyroidism and hyperthyroidism, are associated with changes in the types and amounts of bacteria in the gut. For example, some studies have found a decrease in beneficial bacteria like Bifidobacteria and Lactobacilli in hyperthyroidism, while others have observed increased levels of certain bacteria like Veillonella and Paraprevotella in hypothyroidism. Immune System Modulation: Thyroid hormones can influence the immune system, and the gut microbiota plays a crucial role in shaping the immune system. Alterations in the gut microbiome due to thyroid issues can lead to immune dysregulation, which can potentially contribute to or exacerbate autoimmune thyroid diseases. (As our diet has several components that modulate the immune system this might explain why our diet contributes to a more stable thyroid function, when bringing appropriate useful nutrients like Se, I or Fe). DOI: 10.4236/fns.2012.33059 Thyroid diseases can exacerbate disturbances in the microbiota. Inducing immune-inflammatory responses, altering iodothyronine metabolism, and affecting thyroid-associated micronutrient absorption are potential pathways through which the microbiota and metabolites are involved in thyroid homeostasis. Nevertheless, the causal relationships between gut microbiota and thyroid diseases, how gut microbiota modulates thyroid autoimmunity, and the specific mechanisms by which a particular bacterium or core flora triggers thyroid diseases, are still poorly understood. Source: Front. Endocrinol., August 2022 The relationships between the gut microbiota and its metabolites with thyroid diseases. How Gut Microbiota Impacts Thyroid (through the thyroid hormone synthesis) The gut microbiota can influence the availability of essential nutrients, like iodine, selenium, zinc, and iron, which are crucial for thyroid hormone synthesis. Inflammation and "Leaky Gut" Dysbiosis (an imbalance in the gut microbiome) can disrupt the gut barrier, potentially leading to increased inflammation and "leaky gut," which can further impact thyroid health and potentially contribute to autoimmune thyroid conditions. Summary In essence, the thyroid and the gut microbiome are intricately linked, and disruptions in one can affect the other, highlighting the importance of a healthy gut for overall thyroid health and vice versa.

@16characterstwas @EagleTwoRomeo Hope those help. Again, I wouldn’t take more than 4 or 5 mcg per hr, since that’s around the amount the body normally produces per hour (If I really wanted to take more i would take 4 or 5 mcg/hr several times a day rather than all at once) Above all It’s important to go by how one feels. If i got jittery I’d stop and then when restarting make sure i took it less frequently, ie a lower total amount per day.

Now brand has a nice vit e with gamma.

You wrote you were visiting your in-laws. Is it possible you had a different brand of orange juice than usual and had an allergic reaction to something in that brand? Did you have anything else high in histamine since then (aged cheese, dark chocolate, fermented foods, red wine, ...) and experienced the same flush of the skin? If you still have problems breathing, baking soda could also help. One teaspoon of baking soda in some water.

@Turk what's the best glycine?

https://youtu.be/UPfqamxPmU4?si=ODLrEc8S0ef6-hms https://youtu.be/ScphI4jReJ0?si=K1E8fJOnL_C3ksrc https://youtu.be/5tSR0Vl6btE?si=gt-D6GKRrROUrzfc

bump bump

@SanguisEtAqua Yes, it is probably metabolic. Check your body temp when you are lacking imagination. It's probably at or below 37°C. Childlike play, which includes creativity, requires high body temp.

@RayPeatFan said in Vit E and Vit K: Where is the study that claims HD Vit K could contribute to Vit E deficiency? No deficiency but possibly preventing from assimilation. No clear proof. Most studies establish the fact that we should avoid HD vit E (> 300 UI) when taking vitamin K, especially K1. It makes sense (conversion to MK4 more complicated). But that's not this aspect I mentioned. I'm talking about HD MK4 supplement with 400 UI vitamin E. So, studies establishing why or at least mention the advice we shouldn’t take Vit E at the same time as HD K2. Mechanisms according to MG Traber (deduction) https://academic.oup.com/nutritionreviews/article-abstract/66/11/624/1868525?redirectedFrom=fulltext Vitamins E and K appear to share the same metabolic pathways because both undergo side chain ω- hydroxylation and b-oxidation to produce their respective metabolites. Possible mechanisms for the vitamin E and K interaction *) Vitamins E and K share the same metabolic pathways *) Vitamin E competes for the enzyme (yet undiscovered) that truncates the K1 side chain to form menadione; *) Vitamin E increases xenobiotic pathways that increase the metabolism and excretion of all vitamin K forms from the liver; *) Vitamin E competes with K1 for the cytochrome P450 (CYP) that ω-hydroxylates the tail, thereby preventing the b-oxidation of the tail to form menadione. The latter mechanism is hypothetically less likely because, as discussed by Thijssen et al. (11), there is likely to be steric hindrance preventing the complete removal of the K1 side chain via b-oxidation for menadione formation. All of these mechanisms would decrease the production and/or availability of MK-4. The hypothesis that vitamin E interferes with the conversion of K1 to MK-4 is supported by the observations that MK-4 concentrations in extrahepatic tissue are lower in rats fed a high vitamin E diet.

@lobotomize-me If there is a consensus, it is Vitamin A is needed by the body. If there is too much of what is good, it will be bad. Vitamin A is no exception. Why you are here and there is a here is because many of the members here that used to be in the other forum could not stand the authoritarian insistence of its admin that vitamin A is toxic. I personally feel eating liver for retinol, or vitamin A, does wonders that eating the precursor of vit A, beta-carotene (as popularly found in carrots) could not do for me. For eating beef liver once a week for 5 years, my myopia was gone and my driver's license did not require me to wear glasses anymore.

@gg12 Vitamin E is a generic term that encompasses synthetic to natural, single isomer to multi-isomer, to el cheapo useful stuff like the ones find in multi-vitamins like tocopherol acetate. Know your vitamin E.

yeah, I doubt it’s that but my results are quite weird… my body cannot utilize B6 for some reason

@16characterstwas @Tarzan17 &this Post in thread 'Ray Peat Email Advice Depository' https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-882797 Milk and sugar, custard with a minimum of egg (only natural vanilla for flavor), eggs, meat, and sweet ripe orange juice, are the easy things to digest. Even small amounts of plant material can cause inflammation for some people".

I've only gotten weird gut issues with progesterone when taking 30mg+ topical in ethanol per day. And even then, it sorts itself out within 4 to 6 hours. Small doses <12mg/day or so don't have this effect on me.

@CrumblingCookie LOL! I've been observing my stools. They look rather pale and I may not be forming stools with the help of bile. And I have skin itching, and this could be from using Emeramide to detox lead. I suspect it's because the lack of bile is keeping the lead from being excreted thru the fecal route, and it is using my skin as an alternate route for excretion. Perhaps the urinary route can handle only so much.

To continue on the topic @randomname brought up Post in thread 'Ray Peat Email Advice Depository' https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-875276 Q: Thank you Dr.Peat One more question You talked about the negative effects of darkness. So, I was wondering. If someone is a night owl and he spends his night time with a good incandescent light turned on, drinking and eating some sugary stuff, calcium, sodium etc - would the negative effects of darkness be diminished in any way? RP: Yes, even intermittent bright light can reduce the damage.

low fat high carb diet probably.

I've overdone thyroid before and the nerve-damage type symptoms will go away and you will recover. Some thiamine, niacinamide, and a couple months of decent eating and rest and you should be back to normal.

@jamezb46 do you take gelatin (oxtail, wings, shanks, jello, Great Lakes gelatin,..) along with the meat to help balance out the aminos?