@Tarzan17 It may help to understand addiction thru a Peaty perspective.

It really comes down to low dopamine and elevated serotonin.

Heal the liver and you'll be surprised what might happen.

@jamezb46 Okay thank you. Do you take both of them every day? Or cycle on and off?

@Sunniva Thank you!

@Sugarnotsnow will do, thanks!

@AndrewPeatMatrix I would take it with K2 and magnesium to optimize absorption. I always prefer sunlight but during long periods of time with little sunlight, the supplement works well.

@schemingfonzie I had trouble digesting potatoes and any starch with SIBO symptoms. When i relieved my SIBO using thyroid, antibiotics, and eating low fiber for a couple months I was able to tolerate them again

@AndrewPeatMatrix said in MTHFR - intense anxiety from methyl b vitamins:

i have mthfr, took some methyl b6 & b12, i had taken them a couple years ago daily with 0 issue. wondering why now they are causing an issue.

my first guess it get magnesium & vit D tested. Or maybe i was low on b vitamins and i took too much too soon?

Not sure what to do

B vitamins often have issues with contamination and allergens. Its better to get them from food. Eat liver and oysters often

@yerrag Yea if i were to start eating veg again i would start with leaves. They definitely seem the most beneficial. Turnip greens are my fav

@deliciousowl Do you show signs of low t?

Hydrogen sulfide has a distinct rotten eggs smell. I am wondering if you have smelly farts and think you need to detox.

4 Foods You Should Eat If You Want Less-Smelly Farts

Remedies for Foul Smelling Gas

@pannacottas No it was a popular quote-on-quote "supplier" from Xitter who advertises very heavily to peatosphere folks with testimonials, bloodwork, etc. I won't say exactly who because I got harassed by randoms last time I made this claim. I'm not certain what exactly I got but it was very disappointing compared to haidut's androsterone, or even just pansterone, and this product was allegedly dosed much higher than what I have used of either of those.

It seemed simultaneously to be suppressive but not really apparent in effect, possibly just grossly underdosed. Or, I suppose it's possible that it was just testosterone in DMSO, which seems most likely to be honest.

11-Keto supposedly has longer half-life but it's underesearched. I know plain DHT is a bit harder to get but i would get that over idealabs.

Dosing wise you can start with 10-25mg transdermal dissolved in DMSO, DMSO+ethanol, ethanol+IPM/tocoherol etc. Or maybe 10mg oral dissolved/mixed in tocopherol or 20mg with some spirit like vodka. I think these are low enough to not cause supression and if you feel/don't feel any effects you can dial it up/down from there.

@LucH Thank you for this!

@Kilgore

@Kilgore said in 6+ cups of coffee a day cuts suicide risk by 80%.:

@Ecstatic_Hamster said in 6+ cups of coffee a day cuts suicide risk by 80%.:

I can drink only about 3 cups of very strong coffee daily. After that it starts affecting my sleep quality.

I have read that if coffee impacts your sleep quality it is a sign of a glycogen depleted liver.

Not sure about this. I can easily sleep with coffee, no problem. But sleep quality seems universally affected.

https://www.sciencedirect.com/science/article/abs/pii/S1389945702000151
Methods: In the first part of the study, six volunteers drank either decaffeinated or regular coffee in a double-blind fashion on one day, and the alternate beverage 7 days later. Sleep parameters were assessed by actigraphy. In the second part of the study, the subjects again drank either decaffeinated or regular coffee, and they then collected urine every 3 h for quantitation of 6-sulphoxymelatonin (6-SMT), the main metabolite of melatonin in the urine.

Results: We found that drinking regular caffeinated coffee, compared to decaffeinated coffee, caused a decrease in the total amount of sleep and quality of sleep, and an increase in the length of time of sleep induction. Caffeinated coffee caused a decrease in 6-SMT excretion throughout the following night.

Conclusions: The results of our study confirm the widely held belief that coffee consumption interferes with sleep quantity and quality. In addition, we found that the consumption of caffeine decreases 6-SMT excretion. Individuals who suffer from sleep abnormalities should avoid caffeinated coffee during the evening hours.

Also habitual coffee drinking shrinks pineal gland over lifetime

https://academic.oup.com/sleep/article-abstract/41/10/zsy127/5053876?redirectedFrom=fulltext
We found that smaller VPP was associated with higher cumulative lifetime coffee consumption. Participants who consumed more than 60 cup-years of coffee had VPPs that were smaller by about 20% than individuals who consumed less than 60 cup-years of coffee. The VPP mediated the association between lifetime coffee consumption and sleep efficiency and quality.

Conclusions
Our findings suggest that high lifetime coffee consumption may reduce VPP, and that this reduction in VPP may impair the quality of sleep in late life.

@Chud Did you get your labs back yet or just ordered?

@Sugarnotsnow

I was fortunate to need little tweaking to fix my hypoglycemia, which was a 4yr cold turkey of PUFAs even before I heard of Ray Peat. So I didn't have to take thyroid to get my metabolism going at a fairly good clip. I did one year of therapeutic magnesium supplementation of 800 m elemental daily, and it was to prepare myself to end my lifestyle of relying on soluble fiber intake for good bowel movement. When I did stop soluble fiber intake, I continued to have good bowel movement with good peristalsis driven by having enough magnesium stores.

Still, I have some Tyrone or T3 with me, when coming out of a sick state and my metabolism needed jumpstarting with a little T3.

@Tarzan17 I think peat recommends small frequent feedings that include all three macronutrients. Carbs, proteins, and fats in the right balance per meal.

@Sugarnotsnow Its fine to share info from others but please disclose it!

"Vit E is great for lowering prolactin.

I used 800IU of TocoVit vitamin E daily for 30 days and my prolactin dropped from 8.5 to 2.2.

My prolactin wasn't elevated so it will work even better for someone with high prolactin.

I like TocoVit as it contains lots of alpha-tocopherol, which is responsible for lowering prolactin. It's also a great source of policosinols. "
https://x.com/HansAmato/status/1837529938074689968

The title is a bit misleading.

Speaks little of beta oxidation but more of sugar mitochondrial oxidation.

If we're relying too much in beta oxidation as an an energy source, it will deprive the sugar mitochondrial pathway of oxidative potential or energy to burn sugar mitochondrially, and the alternate sugar pathway of glycolysis will be used. This is where lactate is produced. This leads to lower CO2 production to a point where hypoxia occurs from poor tissue oxygenation, which further restricts sugar metabolism to the glycolytic pathway and less CO2 being produced.

This causes blood sugar to be less absorbed and metabolized and for blood sugar to rise to higher levels, which causes it to be converted to fat and for blood sugar to drop excessively to the point of hypoglycemia. With low blood sugar, adrenaline is produced which causes glycogen to be converted to blood sugar. But if glycogen runs out or isn't available, then cortisol will cause body protein to be converted to sugar, and ammonia will be produced in this conversion.

@sphagnum Yea its hard to find them. They are starting to ban them in dtores. Especially ones that are bright enough