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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    chudlordC
    @jamezb46 is it not more likely that this is merely increased excretion rather than increased absorption?
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    HarlockH
    Gm guys! I got cold urticaria when I am in contact with cold water, cold air, anything cold. Beside bad thyroid, what do you think could be the cause? Cypro works well but puts me in a really tired state that I can't afford. Thx a lot guys! [image: 1789697110092-whatsapp-image-2026-09-18-at-02.52.27.jpeg] [image: 1789697118682-whatsapp-image-2026-09-18-at-02.53.48.jpeg]
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    I was told, "Turkey tail mushroom powder is a ground dietary supplement made from the Trametes versi-color fungus, widely used to support immune function and gut health. The Japanese use this for cancer" Does anyone know anything about this? Being given to a pooch diagnosed with leukemia. Thanks
  • Recipes, food, meal prep, brands. Discuss them all here.

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    JenniferJ
    @Mossy, exactly, and for me, love is the main component—in practice, basing my choices on a love for myself (and others by extension—man being a strand in the web of life and all) and my life, not fear, has proven to be the most healing of all. I believe there is no higher vibration than God and God is love. Thank you for sharing The Four Loves with me. I found a free pdf of it on archive.org and am currently reading it. I had never read anything by C. S. Lewis before, but I was aware he was a Christian apologist so I had some idea of what to expect—I’m not Christian, myself, but having grown up in a Catholic family and attended parochial school, I’m familiar with the Christian concept of God. I think cold can have an effect on an egg’s cloudiness, too, because I’ve had cartons of eggs too close to the refrigerator’s fan that partially froze, and the half that froze and defrosted had very cloudy whites. It’s too bad you can only get the Nounós at Whole Foods. I’ve only found two stores here that carry it. If you can get your hands on Alexandre Family Farm’s whole milk yogurt and strain it, it’s similar. I used to strain the Alexandre’s, but it became too costly at $7.99 for a 24 oz container (roughly 12 oz after straining) daily. For comparison, I paid $5.99 for a 16 oz container of Nounós. No worries. I knew exactly what you meant by mushroom. I should clarify that my experience is not a reflection of the quality of lichen-based D3, but my health status, at the time. My thyroid was still recovering from the trauma of my mum’s passing and for whatever reason, when my thyroid tanks, I struggle with plants so practically everything plant-based was causing hives. I haven’t tried Haidut’s vitamin D, only because I like to take D3 orally for best absorption and don’t care for ethanol, but I appreciate that it doesn’t contain MCT, for those whose intestines would be irritated by it. Have you tried D3 in a base of olive oil? I’m wondering if you would be less sensitive to that excipient? Haha! I take no offense. As a recovering perfectionist, I understand neuroticism well and besides, you’re Italian so I trust your judgment. Now, if you try schooling me on butter, those are fighting words, mister. JK I bring my people shame—I don’t eat butter. Mayo is my dad’s condiment of choice for sandwiches and he doesn’t like the coconut-based one, due to it solidifying in the fridge and needing to take it out in advance to soften it before use, which he doesn’t have the patience for, so I figure the Graza is a good compromise. What type of olive oil do you prefer? I get my dad the “fancy” made with 100% extra virgin olive oil. Is extra virgin not good? While growing up, my mum used mainly butter in her cooking and evoo in her baking—she did cake decorating and swore by oil for moist cakes—so that’s my only reference point.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @PrinceTrebata very ho behaviour not replying. Sorry. I stopped the back ones and still don’t do them( I am still catabolic! Not getting stronger in the gym! Back aches! Bone hurts!) despite getting more than enough protein. This is perfect btw. I am not trying to be anabolic, as that usually entails with some sort of fat growth or water retention from AAS. But that’s a different story more suited for the moggy chicken Currently have been and am doing high seat biking. If I recover (hopefully when I slowly ramp up the calories), and those issues go away, I’ll throw in the stretches and stretching machine. If I find a sustainable routine with time.
  • Vaccines - the cause of society's dysfunction

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    @ursidae said in Vaccines - the cause of society's dysfunction: It is unfortunate. I know a lot of people that only talk to chat gpt, it is their only friend and they prefer it over actual humans. I believe this is a symptom of neurodivergence that people overlook and it will make the people around them that actually love humanity feel isolated, lonely and rejected as their peers continue to choose a chatbot over human connection Possible silver lining is that the hyper-utility of ai / chats may backfire. The specificity and inhumanness may inspire real conversations. The problem may be that people need to be ready to not communicate as they do with chatbots. The spontaneity, intelligence, and experience of actual people will have to be reimagined and patiently accepted.
  • Royal Jelly increases Lifespan in both insects and rats

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    @lobotomize-me 70€ is not superexpensive?
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  • My Protocol for Hypothyroidism + Starch/Fat sensitivity

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    GardnerG
    @Gardner said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @sunsunsun said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @Gardner tolerance to eggs , use raw pineapple with core Not practical , everytime I want to eat egg I have to get somewhere pine apple and then juice it ... crazy No doubt it might work but , don't you get mouth ulcers (canker sore) from eating pineapple ? raw egg is very allergenic for me. Anyway, simply frying eggs (at higher temperature than boiling) deactivates most of allergens and makes them much more tolerable. Oxidized cholesterol is small amount is not a big deal
  • Dr. Garrett Smith asks for help

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    LetTheRedeemedL
    Dam what does insomniac know…
  • Stronger Voice From Ephedrine

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    ThinPickingT
    It may be related to this and replicable another way. https://pmc.ncbi.nlm.nih.gov/articles/PMC4958351/ https://journals.sagepub.com/doi/10.3181/00379727-24-3422 https://pubmed.ncbi.nlm.nih.gov/2039811/ https://www.jabfm.org/content/jabfp/4/4/201.full.pdf
  • Health and science experts that can fill in for Dr. Ray Peat (RIP)

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    LetTheRedeemedL
    Dangit @herenow i was excited to read your comment
  • chicken and turkey

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  • any explanation for photographic memory?

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    GardnerG
    John von Neumann and other Hungarian aliens from early 20th century, they just came to this world with super computer in their head. But maybe there is a role for diet too, the department where John von Neumann worked had very high sugar consumption. Mnemonic techniques work only so far, photographic memory comes naturally to some people.
  • Any solutions for sulfur and salicylate intolerance?

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    SmittyS
    @nicemushroom17 Molybdenum can help with sulfur clearance and glycine for salicylates. I would keep the molybdenum dose under 300mg but with glycine the world is your oyster, find whatever dose makes you feel best and keeps your skin clear. Peat disliked second and third generation antihistamines due to the presence of a Chlorine atom in their structure, which could have potential liver implications. Try 0.5mg of Cyproheptadine before bed for a few weeks and see how you feel, the drowsiness should wear off after a couple weeks.
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    stagS
    @stag While it was suspected by the authors that progesterone may bind to endotoxin directly, another mechanism of its protection may be by increasing the ability of albumin to bind LPS: One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins--it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter. Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase thc organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect. Ray Peat, From PMS to Menopause: Female Hormones in Context
  • Constipation /digestive system/stomach issues

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    LucHL
    @BioEclectic said in Constipation /digestive system/stomach issues: There's one guy with hypertension/hbp who drank about 6oz of my homemade mineral water (Cal-Mag bicarbonate) Not bad at all when you want to deal in crisis. Those persons were deficient and under stress. Note there is here a subtle balance to find. Magnesium as a laxative? Using HD magnesium as a laxative is not appropriate as a usual middle. Why? While using HD magnesium or L-acid ascorbic as an occasional middle could be effective and acceptable, by saturation (HD), it’s not advisable as a usual practice. HD: High Dose. • Not suitable for chronic constipation: Magnesium hydroxide is more appropriate for acute, occasional constipation rather than chronic, ongoing constipation. • Potential for dependency: Long-term use of laxatives, including other magnesium-based ones, can lead to a reliance on them for bowel movements, potentially making the body less responsive to natural stimuli. • Kidney problems: Individuals with kidney problems are more susceptible to the adverse effects of magnesium and may not be able to regulate magnesium levels effectively. Endpoint: Don't take more than the recommended amounts of these laxatives, or use them long-term, because they can throw off your chemistry. Combined with an underperforming kidney or heart failure, saline osmotic laxatives can be dangerous. Source: health.harvard.edu My opinion: These two middles are mechanistic osmotic ways to force the way out. Many people have tried them with success, on occasional circumstances. If the body gets accustomed to this use, natural interprandial bowel won’t come back (between 2 meals, when the bowels get empty). Make a search with “MMC and colon peristalsis” or I can develop if interested. People could get accustomed to the dose and required more substance to get the same osmotic effect. Second, we change the acid-base balance. Third, the way we proceed has an impact on the microbiota… Without mentioning the time we need (unproductive) and the stress we occasion. Short term view.
  • Mycotoxins 101: Testing, Binders, & Detox

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  • Stomach issues / digestive system problems

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    @biogenic Sounds like low thyroid to me. How is your temp/pulse? Have you tried cascara sagrada, activated charcoal, carrot, antibiotics etc? That could improve things but I would look into your thyroid first.
  • Eating the fighting or fleeing animal

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    rohmilchbubiR
    Vaguely related; Why we ignore the suffering of wild animals: Understanding our biases """ Executive summary: This exploratory post argues that widespread neglect of wild animal suffering—despite its immense scale—is driven by a range of cognitive biases, and that overcoming these biases requires conscious effort and intellectual honesty. Key points: Wild animal suffering vastly outweighs human-caused animal suffering, yet it is overlooked even by many animal advocates; this discrepancy is not logically grounded and is likely due to psychological biases. Cognitive biases such as status quo bias, scope neglect, survivorship bias, and compassion fade cause people to underestimate or emotionally disconnect from the scale and severity of suffering in the wild. People tend to empathize more with large, intelligent, or emotionally relatable animals, leading to the neglect of small animals (e.g., insects and crustaceans) that make up the majority of wild animal populations. Biases like omission bias and the idyllic view of nature cause individuals to excuse natural suffering or see it as less morally urgent simply because it is not human-caused. Common reasoning errors, including the assumption that “nature must be good,” false consensus about public opinion, and proportion bias, reinforce inaction by downplaying the moral importance or feasibility of interventions. The author advocates for practicing intellectual honesty and consistent reflection, arguing that only through sustained effort can we overcome our intuitive biases and make more accurate moral judgments about wild animal suffering. """
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    stagS
    @cs3000 this one is interesting too: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice We further demonstrated that bone marrow-derived macrophages (BMDMs) were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone (PQQ), reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
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  • Povidone Iodine as an effective and cheap topical antifungal

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    @Hearthfire It seemingly makes my curls coil a little tighter. Besides that, I haven't noticed much dramatic. Maybe a few new baby hairs.
  • How to decrease puffiness in face

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    methylene blue and progesterone both have this effect on my face.
  • How to stop tyrosine supplement converting to Adrenaline

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    @wester130 As @alfredoolivas mentions: bright light: If i were going to be supplementing with tyrosine, I’d do so in the daytime when planning on being out and getting a good amount of light.