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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    P
    This is very interesting, are there safe methods to lower acetelcholine if serotonin has been lowered? I've been on a previously higher dose of SSRI paxil and have worked with prescribing doctor to lower it to about half the level it was before (other drug I was on have lowered dosage of along with supplemental serotonin agonist drug) Ocd and anxiety have increased greatly while concentration has decreased. For example this post is during school after missing morning dose, whereas on higher doses locking in to concentrate was noticibly easier.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    R
    @alfredoolivas agreed! You want to keep a steady flow of dhea and preg. Otherwise you can take it standalone assuming you're not taking an outrageous amount 10 times a day. Taking it for years, I never experienced suppression
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    M
    @Corngold I do both
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer Oops!  My typo caused the confusion.  I meant to type French toast, not French bread.   There is a common bread brand, like Nature's Own, that has a Brioche that is pretty good.  I just looked it up: Artesano.  I've seen that everywhere. That does make sense, the growing conditions for potatoes being key.  Where the soil, water, and sun provide the quality.  Interesting that baby potatoes are easier to digest.  I'll keep that in mind.  I do remember using Yukon gold for another recipe, and they are creamy.  I think I read they're less waxy than red potatoes, but not as starchy are russet.  I'm wondering now, if the red are too waxy, and the gold would be better, for the potato salad.  I may try them next. Wow, that dairy farm sounds like the best of both worlds: modern and traditional.  And how nice of him (to say the least) to tailor the cow's diet to address your need.  I've never heard of Louis Kervran, I'll have to look him up when I get a chance.  I've never heard of biological transmutation either.  I've lightly touched upon the subject of transmutation, in other reading, but not in the subject of health.  I remember you, and others, mentioning Brix before, which is another subject for my list. No problem, on the Vital Farms tip.  It sounds like you have the knowledge, and access, to get the best eggs where you live, let alone anything else you need.  You must keep up on all of it, with you and your dad's health needs.  I've slacked off a bit, once my health took an up turn, and my budget a down turn.  At least the timing wasn't too bad.  I would imagine the quality of food, and how animals are treated, goes hand in hand.  And I know that more care equals more cost.  Do you buy those eggs locally or are they available in stores? Yes, I was pretty shocked that I can eat bananas again.  I don't recall If I had any issues from cooked bananas, but I could guess I did.  Everything gave me trouble.  I could hardly eat anything during that time.  Ray's advice makes sense, cooking the raw starch.  And needing them to be overripe raw, as well.  Just like with plantains.  I used to love cooked plantains.  They're not native to my diet or cultural heritage, but I adopted them and ate them for a long period.  I have not had them in many years, though.  Years back I hypothesized that my heavy plantain habit may have contributed to my poor health, with all the starch, but I could guess stress caused the poor health and the plantains were proof of the poor state.  I think when you're healthy, you can basically eat like a goat.  I completely relate on the need to simplify meals.  I'm doing that everywhere I can now. That's a lot of potatoes.  You must've gotten creative eating that much.  Yes, we are more than just our bodies, though it's easy to focus the fixing of our defective systems on the mechanical, because it's the most evident and immediate.  No doubt, sometimes a mechanical fix is what's needed, and brings some relief.  I'm glad you've turned some of your focus beyond the physical.  A fit mind and spirit, I feel, is the most important.  Like the body, it has to be worked at and honed.  Which is what it sounds like your repetitive hikes, a change of perspective, helped you with. That is quite the epiphany.  I like the Biblical analogies.  I think it was King David, and some other writers in the Bible, who dealt with severe depression and burdens, who contemplated nature just as you've explained, recognizing the trees and mountains that stood before them were made by the same Creator who made their very body.  There really is relief in that.  I hope you continue to find relief and hope in that.  I feel we are brought to the end of ourselves, through our hardships, so that we might know Who made us, and that we might know our true self.  I find it interesting that you come back to your water analogy, where the idea of free flowing water gives you relief.  You're not the only one.  One of my favorite authors, C. S. Lewis, had a big draw to water, and found relief both in the idea of it, and in literally floating in it. You have the right perspective, about simply being thankful.  I know it's hard for me sometimes to maintain that under the burdens.  But whenever I get my wits about me, I do come back to that.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    C
    I thought aspirin and/or baking soda w water is good for afterwards? Gummy bears or fruit before and during lifting, no?
  • any explanation for photographic memory?

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    GardnerG
    John von Neumann and other Hungarian aliens from early 20th century, they just came to this world with super computer in their head. But maybe there is a role for diet too, the department where John von Neumann worked had very high sugar consumption. Mnemonic techniques work only so far, photographic memory comes naturally to some people.
  • Any solutions for sulfur and salicylate intolerance?

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    SmittyS
    @nicemushroom17 Molybdenum can help with sulfur clearance and glycine for salicylates. I would keep the molybdenum dose under 300mg but with glycine the world is your oyster, find whatever dose makes you feel best and keeps your skin clear. Peat disliked second and third generation antihistamines due to the presence of a Chlorine atom in their structure, which could have potential liver implications. Try 0.5mg of Cyproheptadine before bed for a few weeks and see how you feel, the drowsiness should wear off after a couple weeks.
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    stagS
    @stag While it was suspected by the authors that progesterone may bind to endotoxin directly, another mechanism of its protection may be by increasing the ability of albumin to bind LPS: One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins--it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter. Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase thc organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect. Ray Peat, From PMS to Menopause: Female Hormones in Context
  • Constipation /digestive system/stomach issues

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    LucHL
    @BioEclectic said in Constipation /digestive system/stomach issues: There's one guy with hypertension/hbp who drank about 6oz of my homemade mineral water (Cal-Mag bicarbonate) Not bad at all when you want to deal in crisis. Those persons were deficient and under stress. Note there is here a subtle balance to find. Magnesium as a laxative? Using HD magnesium as a laxative is not appropriate as a usual middle. Why? While using HD magnesium or L-acid ascorbic as an occasional middle could be effective and acceptable, by saturation (HD), it’s not advisable as a usual practice. HD: High Dose. • Not suitable for chronic constipation: Magnesium hydroxide is more appropriate for acute, occasional constipation rather than chronic, ongoing constipation. • Potential for dependency: Long-term use of laxatives, including other magnesium-based ones, can lead to a reliance on them for bowel movements, potentially making the body less responsive to natural stimuli. • Kidney problems: Individuals with kidney problems are more susceptible to the adverse effects of magnesium and may not be able to regulate magnesium levels effectively. Endpoint: Don't take more than the recommended amounts of these laxatives, or use them long-term, because they can throw off your chemistry. Combined with an underperforming kidney or heart failure, saline osmotic laxatives can be dangerous. Source: health.harvard.edu My opinion: These two middles are mechanistic osmotic ways to force the way out. Many people have tried them with success, on occasional circumstances. If the body gets accustomed to this use, natural interprandial bowel won’t come back (between 2 meals, when the bowels get empty). Make a search with “MMC and colon peristalsis” or I can develop if interested. People could get accustomed to the dose and required more substance to get the same osmotic effect. Second, we change the acid-base balance. Third, the way we proceed has an impact on the microbiota… Without mentioning the time we need (unproductive) and the stress we occasion. Short term view.
  • Mycotoxins 101: Testing, Binders, & Detox

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  • Stomach issues / digestive system problems

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    H
    @biogenic Sounds like low thyroid to me. How is your temp/pulse? Have you tried cascara sagrada, activated charcoal, carrot, antibiotics etc? That could improve things but I would look into your thyroid first.
  • Eating the fighting or fleeing animal

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    rohmilchbubiR
    Vaguely related; Why we ignore the suffering of wild animals: Understanding our biases """ Executive summary: This exploratory post argues that widespread neglect of wild animal suffering—despite its immense scale—is driven by a range of cognitive biases, and that overcoming these biases requires conscious effort and intellectual honesty. Key points: Wild animal suffering vastly outweighs human-caused animal suffering, yet it is overlooked even by many animal advocates; this discrepancy is not logically grounded and is likely due to psychological biases. Cognitive biases such as status quo bias, scope neglect, survivorship bias, and compassion fade cause people to underestimate or emotionally disconnect from the scale and severity of suffering in the wild. People tend to empathize more with large, intelligent, or emotionally relatable animals, leading to the neglect of small animals (e.g., insects and crustaceans) that make up the majority of wild animal populations. Biases like omission bias and the idyllic view of nature cause individuals to excuse natural suffering or see it as less morally urgent simply because it is not human-caused. Common reasoning errors, including the assumption that “nature must be good,” false consensus about public opinion, and proportion bias, reinforce inaction by downplaying the moral importance or feasibility of interventions. The author advocates for practicing intellectual honesty and consistent reflection, arguing that only through sustained effort can we overcome our intuitive biases and make more accurate moral judgments about wild animal suffering. """
  • PQQ Pyrroloquinoline quinone (found in space dust) - dietary intake

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    stagS
    @cs3000 this one is interesting too: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice We further demonstrated that bone marrow-derived macrophages (BMDMs) were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone (PQQ), reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
  • This topic is deleted!

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  • Povidone Iodine as an effective and cheap topical antifungal

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    @Hearthfire It seemingly makes my curls coil a little tighter. Besides that, I haven't noticed much dramatic. Maybe a few new baby hairs.
  • How to decrease puffiness in face

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    B
    methylene blue and progesterone both have this effect on my face.
  • How to stop tyrosine supplement converting to Adrenaline

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    @wester130 As @alfredoolivas mentions: bright light: If i were going to be supplementing with tyrosine, I’d do so in the daytime when planning on being out and getting a good amount of light.
  • General Adaptation Syndrome

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  • Resistant starch increase endotoxin?

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    LucHL
    Endotoxins sources when eating starch? Short answer: LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life). Developed theory Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed. Endotoxins from Gut Bacteria Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…) In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free … Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”. Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach). The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.
  • Body Temperature, World Temperature

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    sunsunsunS
    @Corngold go to Spain or western Canada for a vacation xD or le south de Francé
  • What's your body temperature?

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    JenniferJ
    @Corngold, I find the most accurate reading is a rectal reading. Compared to orally and axillary, my temp is at least 1° higher when taken rectally. When the temp is low in comparison to how warm one feels, it’s likely due to adrenaline compensating for poor thyroid function by keeping the core temp up. Often, one or more of the extremities (feet, hands, nose and ears) will be cooler as adrenaline cuts off circulation to them to keep vital organs warm. One way to tell is by taking the temp about 20–30 minutes after eating. If running on adrenaline, the temp will, in most cases, be lower.
  • Rhonda Patrick - deep dive into coffee

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    IsmailI
    @yerrag 100%! Similar to what alot of the keto and carnivore ones thought about reducing/eliminating carbs, and later on realised their mistake(s) (e.g. Thomas Delauer, Mercola, Paul Saladino etc.), though I'm still waiting for Eric Berg to come to that realisation too
  • any good canned oyster brands other than crown prince?

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    @16characterstwas have not tried either yet
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    JenniferJ
    @Mulloch94 said in For those of you FGF21maxxing or otherwise eating low protein, what are you eating?: I'm interested in hearing what all you are eating right now? I didn’t think my diet was low protein, but I average the same amount as you and get upwards of 3,000 calories daily so I guess it is. In hopes of overcoming my dependency on thyroid supplementation, something that has been especially challenging since my mum’s passing in 2022 and my dad’s cancer diagnosis in March of 2024 (I’m his caregiver), I experimented with different protein sources and intakes last year and settled on 65 g daily, which has allowed me to maintain my muscle and bone mass, however, it took upping my fat intake from coconut sources to maintain my cycle and lower my Armour dose from 3 grains to 1. My diet consists of: CARBS (65%) • Apple cider • Bananas (extra ripe) • Figs • Guava juice (Namai—Amazon) • Honeydew melon (juiced) • Jackfruit (Pitaya Foods) • Lychee juice (Namai—Amazon) • Passion fruit juice (Namai—Amazon) • Pineapple juice (Trader Joe’s) • Pink muscat grape juice (Tamaya—Amazon) • Soursop juice (Namai—Amazon) • Watermelon (juiced) • All fruit jam (St. Dalfour)—strawberry, black raspberry, blueberry, apple & cinnamon, fig royale, French grape, mango & passion fruit, pineapple & mango • Honey—Ohi'a Lehua, orange blossom, prairie blossom, tupelo, wildflower, wild blueberry, wild raspberry • Coconut water (Symbiosis and Taste Nirvana) FATS (25%) • Coconut milk (MALK) • Coconut yogurt (Coconut Cult) • Young Thai coconut meat (Symbiosis) • Coconut butter (Artisana) • Coconut oil (365 Whole Foods and Tropical Traditions) PROTEINS (10%) • Heirloom eggs • Sea scallops • Coconut yogurt (Cocojune Greek-style) MISCELLANEOUS • Dill pickles (Bubbies) • Mung bean sprouts • Mushroom “umami” powder (Trader Joe’s) • Coconut aminos (Coconut Secret) • Instant decaf coffee (Mount Hagen) • Three mint tea (Pukka Herbs) • Lemon ginger tea (Pukka Herbs) • Vanilla bean powder (Bakto Flavors) • Ceylon cinnamon (Simply Organic) • Salt (Morton’s pickling) EXAMPLE DAY OF EATING Breakfast: Flourless banana crêpes stuffed with yogurt and jam, apple cider and sweetened (coconut) milky coffee Snack: A liter of lychee juice Lunch: Seared scallops with a mango & passion fruit teriyaki glaze, and a piña colada (coconut) milkshake Snack: A liter of guava juice Dinner: Cantonese omelette, yogurt stuffed figs with ohi’a lehua honey, “nice” cream, and sweetened milky coffee Before bed: Honey sweetened three mint tea
  • how dangerous is Metyrapone - cortisol inhibitor?

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    samsonS
    @jamezb46 ya serotonin stimulates HPTA directly, thus inducing cortisol