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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    692 Topics
    5k Posts
    C
    And I was looking for the answer on whether FMTs are a guarantor for clearance of fungal abundance in the small intestinal or colonic lumen. Surprisingly, it's a no! It appears to be even the other way round. Here's something interesting IMO about FMTs: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection, 2018 In this study, it is shown that CDI is strongly accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Post-FMT, successful responders lack their previous C. albicans dominance but rather display a high relative abundance of Saccharomyces and Aspergillus. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. In essence, therefore, annihilation of Candida dominance in CDI patients is crucial for FMT success and arguable it could be much advisable to pre-/co-treat any CDI with antifungals along with either ABx or FMT. Another study showed contrasting results of FMT on UC: Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis, 2020 Herein they showed that in contrast to FMT in CDI, clinically successful response to FMT in UC very much depended on high Candida abundance at baseline, which decreased after FMT. The authors argue that the prior Candida dominance may provide a specific niche for bacterial engraftment, ameliorating UC. So, the very opposite of the pre-conditions in CDI. However, what the authors do not talk about in their text but what their graphs clearly show is the following caveat: UC patients with a low relative Candida abundance at baseline did not only not clinically benefit from the FMT, but their dysbiosis, inflammation and Candida levels post-FMT was mostly even larger than before (confounders? Small sample size?): [image: 1-s2.0-S1931312820301700-fx1.jpg] [image: 1-s2.0-S1931312820301700-gr2.jpg]´

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    Z
    “Many people feel positive emotions in their organ nerve centers, for example the heart plexus and the solar plexus. The good feelings go with good functions. When the nerves cringe because of the presence of authoritarians, the nerve supply to the organs is impaired. Thinking of the offensive person is enough to do it. Food, activity, and feelings about your surroundings go together, and it’s important to listen to your viscera, to really participate in constructive living.” – Ray Peat The cringing of nerves blocking blood flow resulting in a stress reaction is obvious to me in the presence of some people (or a certain personality). Complete avoidance of these people is not possible and exposure therapy hasn’t worked so far. Has anyone been able to overcome this and if yes, how did you do it?

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    395 Topics
    4k Posts
    daposeD
    I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone

  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
    2k Posts
    Milk DestroyerM
    @alfredoolivas Perhaps, but I'm not certain. I actually was eating a lot more kale recently (maybe 150g a day) for a week and I did notice I had lost some weight (like 5lbs), but I was also walking in nature more at the time. I'll try incorporating it more consistently and get back to you.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
    1k Posts
    alfredoolivasA
    @hawk1 okay you actually had agency & balls and settled with some pretty decent sources. It took you two months, but I’m proud of you if that means anything.
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  • S

    What's your body temperature?

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    JenniferJ
    @Corngold, I find the most accurate reading is a rectal reading. Compared to orally and axillary, my temp is at least 1° higher when taken rectally. When the temp is low in comparison to how warm one feels, it’s likely due to adrenaline compensating for poor thyroid function by keeping the core temp up. Often, one or more of the extremities (feet, hands, nose and ears) will be cooler as adrenaline cuts off circulation to them to keep vital organs warm. One way to tell is by taking the temp about 20–30 minutes after eating. If running on adrenaline, the temp will, in most cases, be lower.
  • IsmailI

    Rhonda Patrick - deep dive into coffee

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    IsmailI
    @yerrag 100%! Similar to what alot of the keto and carnivore ones thought about reducing/eliminating carbs, and later on realised their mistake(s) (e.g. Thomas Delauer, Mercola, Paul Saladino etc.), though I'm still waiting for Eric Berg to come to that realisation too
  • ChudC

    any good canned oyster brands other than crown prince?

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    @16characterstwas have not tried either yet
  • M

    For those of you FGF21maxxing or otherwise eating low protein, what are you eating?

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    JenniferJ
    @Mulloch94 said in For those of you FGF21maxxing or otherwise eating low protein, what are you eating?: I'm interested in hearing what all you are eating right now? I didn’t think my diet was low protein, but I average the same amount as you and get upwards of 3,000 calories daily so I guess it is. In hopes of overcoming my dependency on thyroid supplementation, something that has been especially challenging since my mum’s passing in 2022 and my dad’s cancer diagnosis in March of 2024 (I’m his caregiver), I experimented with different protein sources and intakes last year and settled on 65 g daily, which has allowed me to maintain my muscle and bone mass, however, it took upping my fat intake from coconut sources to maintain my cycle and lower my Armour dose from 3 grains to 1. My diet consists of: CARBS (65%) • Apple cider • Bananas (extra ripe) • Figs • Guava juice (Namai—Amazon) • Honeydew melon (juiced) • Jackfruit (Pitaya Foods) • Lychee juice (Namai—Amazon) • Passion fruit juice (Namai—Amazon) • Pineapple juice (Trader Joe’s) • Pink muscat grape juice (Tamaya—Amazon) • Soursop juice (Namai—Amazon) • Watermelon (juiced) • All fruit jam (St. Dalfour)—strawberry, black raspberry, blueberry, apple & cinnamon, fig royale, French grape, mango & passion fruit, pineapple & mango • Honey—Ohi'a Lehua, orange blossom, prairie blossom, tupelo, wildflower, wild blueberry, wild raspberry • Coconut water (Symbiosis and Taste Nirvana) FATS (25%) • Coconut milk (MALK) • Coconut yogurt (Coconut Cult) • Young Thai coconut meat (Symbiosis) • Coconut butter (Artisana) • Coconut oil (365 Whole Foods and Tropical Traditions) PROTEINS (10%) • Heirloom eggs • Sea scallops • Coconut yogurt (Cocojune Greek-style) MISCELLANEOUS • Dill pickles (Bubbies) • Mung bean sprouts • Mushroom “umami” powder (Trader Joe’s) • Coconut aminos (Coconut Secret) • Instant decaf coffee (Mount Hagen) • Three mint tea (Pukka Herbs) • Lemon ginger tea (Pukka Herbs) • Vanilla bean powder (Bakto Flavors) • Ceylon cinnamon (Simply Organic) • Salt (Morton’s pickling) EXAMPLE DAY OF EATING Breakfast: Flourless banana crêpes stuffed with yogurt and jam, apple cider and sweetened (coconut) milky coffee Snack: A liter of lychee juice Lunch: Seared scallops with a mango & passion fruit teriyaki glaze, and a piña colada (coconut) milkshake Snack: A liter of guava juice Dinner: Cantonese omelette, yogurt stuffed figs with ohi’a lehua honey, “nice” cream, and sweetened milky coffee Before bed: Honey sweetened three mint tea
  • W

    how dangerous is Metyrapone - cortisol inhibitor?

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    samsonS
    @jamezb46 ya serotonin stimulates HPTA directly, thus inducing cortisol
  • J

    How to get a prescription for antibiotics ?

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    J
    thanks guys
  • B

    What was Albert Szent-Györgyi health regiment like?

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    1
    @heyman umlauts help too
  • highseabaschH

    The Heart Remembers

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    1
    Yeah. As does the whole organism it seems: [image: 1749591238645-477011e9-bd19-44f2-8981-8d2ba0d0485d-image.png]
  • gg12G

    coffee questions

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    LucHL
    Thanks or flowers. But before answering a question I have to asked myself if my answer could help other readers (I'm a retired teacher). If they're ready to hear what I want to say. Supposition, of course. I need to spare energy, as well, and feel it can be useful. (...) For instance, about "high level glucose". Not a bad idea for those ones who suffer from a pathology, to help the body to set things in order if ... Observe the" if". Or simply to gain energy if you metabolize glucose well, with the ability to adapt, to listen to your body... But I have no "legitimacy". So I have to cite sources and to make the balance. (...) We must also let people experiment. Some will make mistakes, including me in perception, and then they will correct their course. But be careful to keep a little energy to help the body change course. As Haidut would say: See, perceive and act! Additional info when we want to manage / moderate / adapt: Caffeine and CYP1A2 detox pathway https://bioenergetic.forum/topic/6434/caffeine-and-cyp1a2-detox-pathway => Estrogen and caffeine are both broken down in the liver by the CYP1A2 enzyme. useful info on coffee and caffeine (in French, translator needed) Caféine, ami ou ennemi ? (caffeine, friend or foe?) http://mirzoune-ciboulette.forumactif.org/t1523-cafeine-ami-ou-ennemi#17789 Coffee: Friend or foe? The answer won't be clear-cut: As is often the case, it's not all black and white. How can you optimize your situation if you enjoy drinking coffee? You have to consider the context: Coffee is an alkaloid of the methylxanthine family, present in many foods, which acts as a psychotropic stimulant (+/moderate, depending on the environment) and a mild diuretic. Alkaloids are part of the plant's defense system. But it's all in the dose (…) Imbalance (insufficient base intake) and stress management The liver's ability to convert caffeine into paraxanthine Caffeine toxicity and cytochrome P450 Habituation phenomenon and interference between adenosine and theobromine Mechanism: How does caffeine affect receptors? Caffeine therefore acts as an inhibitor. Caffeine is said to antagonize adenosine receptors and thus allow an increase in dopaminergic activity. Hormesis: Principle of hormesis "What doesn't kill us makes us stronger!" Teasing an organism, which has the capacity to recover from this stress and eliminate toxins, is good in itself. Sources and references (21x).
  • S

    36 hours into my raw milk a2 fast

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    S
    @evan-hinkle said in 36 hours into my raw milk a2 fast: s it whole milk? Peat typically recommended low fat milk. If it is full fat, do you have any history of poor fat digestion? If don’t could explain feeling low energy. Just some ideas yes its raw whole fat milk a2
  • alex155A

    familial hypercholesterolemia

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    alex155A
    @Mulloch94 Understood! Thank you)
  • M

    Tim has returned

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    M
    Another Tim vid just dropped https://www.youtube.com/watch?v=GACui0kERm8 let the record stand I agree with everything except virgin coconut oil....use the slutty stuff instead. She's a good girl that does as she's told.
  • B

    So did anyone try the D/K on the penis

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    A
    @Wabi-sabi thankfully it isn't permanent accumulation, and it does gradually start to return to baseline after stopping supplementation (same can be said for Vitamin D).
  • W

    Adolescene based cycle for heightmaxxing

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  • MauritioM

    RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman

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    MauritioM
    @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: My question is, anabologies honey diet formulation was eating one pound of ground beef a night… every night. Are you guys @ThinPicking @Mauritio calling this MR or protein restriction? That seems wrong if you are No you're right that's not protein restriction. The honey diet would fall under the category of "intermittent protein restriction". The sugar diet/ sugar fast would be real protein restriction. They're all grouped together in this video and in my response as well, because they all increase FGF21. And contrary to Jay's statement it does not take 7 days to increase FGF21 significantly, but less than 2 h. See the OP. So, the honey diet qualifies for " things that increase FGF21" since for a significant part of the day you do get the FGF21 increase. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Jay was slamming on fgf21 increasing reductive stress. Well maybe it balances out? I have a part on that in the OP. Look for "Reductive stress" and the following part on the ETC. If you read those quotes and studies it seems clear to me that FGF21 isn't a cause of reductive stress but a reaction to it. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Then Georgi chimes in later on fructose lowers phosphorus to calcium ratio, by conversion of fructose into glucose consumes phosphorus Klotho lowers phosphate. And FGF21 increases Klotho. So FGF21 lowers phosphate, thereby increasing the calcium/phosphorus ratio. Making it possible to have a decent ratio while mostly consuming fruit and sugar and little dairy. I have a post about Klotho and FGF21 on X. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Id be interested in hearing actual criticism of the honey diet rather than Jays knee jerk reaction. Same! I'm not saying the honey diet is the end all be all. Or that it is the perfect diet. I think it's a good diet, for some people, for a limited amount of time. It's a good tool. I'd love to hear a more nuanced criticism, because what Jay put out was quite twisted and one sided. It's like he had his conclusion first and then looked at the studies.
  • alex155A

    Bifidobacterium

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    alex155A
    I also plan to add Lactobacillus Reuteri to the yogurt and see what happens https://pubmed.ncbi.nlm.nih.gov/38487926/
  • sabupaS

    Thoughts on this light nootropic stack?

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    sunsunsunS
    too much cholinergic stuff can cause an awful depression/nausea after enough time on it.
  • S

    megadosing different magnesium supplements

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    S
    @Wabi-sabi said in megadosing different magnesium supplements: Quinoa, Buckwheat, Amaranth, or even W What about it?
  • energy-structureE

    On The Back of a Tiger

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    R
    @Mulloch94 identity politics is dumb. Correct, identity politics is objectively rightist. The Marxian class theory is junk. Ultraleftism is bad. Xi Jinping called the class struggle of the late Mao period a "leftist mistake". The class structure of a society is a powerful explanatory factor in its functioning, though. India is worse off than China, despite starting in a similar place in the 1980s, because of the caste system's retardation of development. The typical "indian factory" video online consists of almost early-industrial constructions from the 1800s. Similar story for UK vs USA. Or Nazi Germany vs USSR. Less class tension means more coherence, productivity, war-fighting prowess. Which is why the US will lose to China in the next few decades, BTW, unless something incredible happens internally (it won't, though, until the bitter end) The same social networks that enabled Capitalism to rise are the same ones that allow Communism to function. Yep. And when those networks fail, you get a breakdown in the system (which we have seen). Sure. Requiring the establishment of new networks, and re-definition of the existing ones. This is the revolution and the historical-materialist development, et c.
  • I

    Defanging your computer

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    I
    @Androsclerozat I think it's the screen itself - can't be good to look INTO light for hours.