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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    thebiooracleT
    @secondkelping Glad the shedding is already easing up. Peat talked about this on the Get Fit with Jodelle podcast in 2022: "Scalp massage definitely helps hair loss from a variety of causes." The way he described it was keeping your fingertips planted on the scalp and wiggling them so the skin moves around. Then he said "That kind of 15 minutes per day amount of massage can very significantly improve hair growth." How long are your sessions now? Would like to hear how the vitex goes too.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    C
    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    sunsunsunS
    #dogoyimreally
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    JWayneJ
    @wester130 I doubt that will feel anything from DHEA and progesterone at that dose. But the exemestane is potent enough to have an effect. All you can do is try and see what produces the most benefits for you. The good news is that even if you think you made a mistake (which at these very low doses is not really a concern), your hormones will stabilize within a few days. For instance, I've taken 400mg pregnenolone and 50mg DHEA and 12.5mg exemestane and didn't experience anything wild. I've also taken various doses of exemestane without DHEA/pregnenolone/progesterone. Any low estrogen symptoms go away within 1-3 days of ceasing A.I. administration.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer OK, well, I put the onus on them for any confusion with being a library, given their name .  Seems like an interesting project, though very limited, beyond allowing people to get random books. Though, I could imagine a random book could be just the answer for someone in need of inspiration and prior having had no books at all. Indeed, a little win mixed with a Darwin award, for absent mindedness.  Though, ultimately, the verdict is still out on my capacity to take supplements.  Based on the last 10+ days, I'd say my body is still not completely receptive to exogenous things. Though, time will really tell. Wow, that is quite a testimony against doctors of any kind.  I think many people tend to have a sense that alternative doctors may have our better interest in mind, but your experience backs up my own, that many doctors and institutions are seemingly no better than the high-profit and ego-minded conventional doctors.  Where there are alternative doctors that don't necessarily have high-profit in mind, ego tends to drive them, which can be just as bad.  The moral of the story, is that to get something right in an imperfect world is very hard.  That's why those who are indeed good at what they do stand out.  But even then, only so much success can be had by a medical doctor: fixing humans is a very hard job.  I had considered going to a star naturopathic doctor, after my failure with a TCM doctor, but by that time I had soured on the idea of any doctors, for they only seemed interested in my money.  Apart from conventional medicine for emergency situations, I tend to still feel this way. Yes, if there is one take away 15 years after my health decline, it's that reducing stress will do wonders.  Mental stress is number one, though eventually physical stress can break you down as well.  And stress in the sense of worry and incessant, anxious rumination; not just the working out and solving problems by the turning of the mental gears.  I see the latter as actually, generally, beneficial. Right in line with my previous comment, I think caloric need can be based just as much on mental activity as physical.  Heavy mental activity tends to keep my metabolism high, even when not that physically active.  So maybe that is where part of your caloric requirements lie, supplying fuel for the mental activity. I didn't make cornbread, but it's on my list to do every day.  I just haven't gotten around to it yet.  I'm undecided on the fat to use, though all three are on the table: bacon, butter, and coconut oil.  I think coconut oil will make the softest version, but maybe bacon or butter would be tastier.  If you can believe it, I didn't like the homemade English muffins!  My dad likes them, but I thought the taste was sub-par to store bought.  The only advantage I can see is the softness when you eat one freshly made.  But, with a whole batch, there are many left over that will not have the soft, just made taste.  Given the difficulty in making them, with a stickier than normal dough, if I can find store-bought with low PUFA and non-GMO, I'll buy those.  I think it would be too much to ask for glyphosate-free flour in store bought, though I'd prefer that as well. Yeah, that Painterland Sister's yogurt is one of the best I've had.  I actually did buy another carton, because it was on sale.  There's something about full fat milk that seemingly gives me weight gain, but it's unmatched in taste.  Having learned about 6 months ago true full-fat dairy is far above 4%, I consciously look for it now.  I don't think it's the saturated fat specifically.  Could there be something else about dairy causing it?  My metabolism in general has slowed down, but I have been much less active; so, it may be that.  I realize the perspective is that saturated fat doesn't cause weight gain; and my brother's carnivore diet is proof of that.  Maybe it's simply the additional calories, as you mention.  Yes, I think I'd rather eat full-fat dairy, and less of other calories.  I've just remembered, that Ray consumed low-fat dairy.  How do you think that jives with his pro-saturated fat perspective—simply a desire to reduce calories, not saturated fat? P.S. I did make potato salad with true baby/petite gold potatoes, and it was very good.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    HarlockH
    @hawk1 Thx bro cheking rn
  • chicken and turkey

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  • any explanation for photographic memory?

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    GardnerG
    John von Neumann and other Hungarian aliens from early 20th century, they just came to this world with super computer in their head. But maybe there is a role for diet too, the department where John von Neumann worked had very high sugar consumption. Mnemonic techniques work only so far, photographic memory comes naturally to some people.
  • Any solutions for sulfur and salicylate intolerance?

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    SmittyS
    @nicemushroom17 Molybdenum can help with sulfur clearance and glycine for salicylates. I would keep the molybdenum dose under 300mg but with glycine the world is your oyster, find whatever dose makes you feel best and keeps your skin clear. Peat disliked second and third generation antihistamines due to the presence of a Chlorine atom in their structure, which could have potential liver implications. Try 0.5mg of Cyproheptadine before bed for a few weeks and see how you feel, the drowsiness should wear off after a couple weeks.
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    stagS
    @stag While it was suspected by the authors that progesterone may bind to endotoxin directly, another mechanism of its protection may be by increasing the ability of albumin to bind LPS: One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins--it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter. Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase thc organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect. Ray Peat, From PMS to Menopause: Female Hormones in Context
  • Constipation /digestive system/stomach issues

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    LucHL
    @BioEclectic said in Constipation /digestive system/stomach issues: There's one guy with hypertension/hbp who drank about 6oz of my homemade mineral water (Cal-Mag bicarbonate) Not bad at all when you want to deal in crisis. Those persons were deficient and under stress. Note there is here a subtle balance to find. Magnesium as a laxative? Using HD magnesium as a laxative is not appropriate as a usual middle. Why? While using HD magnesium or L-acid ascorbic as an occasional middle could be effective and acceptable, by saturation (HD), it’s not advisable as a usual practice. HD: High Dose. • Not suitable for chronic constipation: Magnesium hydroxide is more appropriate for acute, occasional constipation rather than chronic, ongoing constipation. • Potential for dependency: Long-term use of laxatives, including other magnesium-based ones, can lead to a reliance on them for bowel movements, potentially making the body less responsive to natural stimuli. • Kidney problems: Individuals with kidney problems are more susceptible to the adverse effects of magnesium and may not be able to regulate magnesium levels effectively. Endpoint: Don't take more than the recommended amounts of these laxatives, or use them long-term, because they can throw off your chemistry. Combined with an underperforming kidney or heart failure, saline osmotic laxatives can be dangerous. Source: health.harvard.edu My opinion: These two middles are mechanistic osmotic ways to force the way out. Many people have tried them with success, on occasional circumstances. If the body gets accustomed to this use, natural interprandial bowel won’t come back (between 2 meals, when the bowels get empty). Make a search with “MMC and colon peristalsis” or I can develop if interested. People could get accustomed to the dose and required more substance to get the same osmotic effect. Second, we change the acid-base balance. Third, the way we proceed has an impact on the microbiota… Without mentioning the time we need (unproductive) and the stress we occasion. Short term view.
  • Mycotoxins 101: Testing, Binders, & Detox

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  • Stomach issues / digestive system problems

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    H
    @biogenic Sounds like low thyroid to me. How is your temp/pulse? Have you tried cascara sagrada, activated charcoal, carrot, antibiotics etc? That could improve things but I would look into your thyroid first.
  • Eating the fighting or fleeing animal

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    rohmilchbubiR
    Vaguely related; Why we ignore the suffering of wild animals: Understanding our biases """ Executive summary: This exploratory post argues that widespread neglect of wild animal suffering—despite its immense scale—is driven by a range of cognitive biases, and that overcoming these biases requires conscious effort and intellectual honesty. Key points: Wild animal suffering vastly outweighs human-caused animal suffering, yet it is overlooked even by many animal advocates; this discrepancy is not logically grounded and is likely due to psychological biases. Cognitive biases such as status quo bias, scope neglect, survivorship bias, and compassion fade cause people to underestimate or emotionally disconnect from the scale and severity of suffering in the wild. People tend to empathize more with large, intelligent, or emotionally relatable animals, leading to the neglect of small animals (e.g., insects and crustaceans) that make up the majority of wild animal populations. Biases like omission bias and the idyllic view of nature cause individuals to excuse natural suffering or see it as less morally urgent simply because it is not human-caused. Common reasoning errors, including the assumption that “nature must be good,” false consensus about public opinion, and proportion bias, reinforce inaction by downplaying the moral importance or feasibility of interventions. The author advocates for practicing intellectual honesty and consistent reflection, arguing that only through sustained effort can we overcome our intuitive biases and make more accurate moral judgments about wild animal suffering. """
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    stagS
    @cs3000 this one is interesting too: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice We further demonstrated that bone marrow-derived macrophages (BMDMs) were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone (PQQ), reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
  • This topic is deleted!

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  • Povidone Iodine as an effective and cheap topical antifungal

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    R
    @Hearthfire It seemingly makes my curls coil a little tighter. Besides that, I haven't noticed much dramatic. Maybe a few new baby hairs.
  • How to decrease puffiness in face

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    B
    methylene blue and progesterone both have this effect on my face.
  • How to stop tyrosine supplement converting to Adrenaline

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    @wester130 As @alfredoolivas mentions: bright light: If i were going to be supplementing with tyrosine, I’d do so in the daytime when planning on being out and getting a good amount of light.
  • General Adaptation Syndrome

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  • Resistant starch increase endotoxin?

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    LucHL
    Endotoxins sources when eating starch? Short answer: LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life). Developed theory Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed. Endotoxins from Gut Bacteria Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…) In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free … Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”. Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach). The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.
  • Body Temperature, World Temperature

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    sunsunsunS
    @Corngold go to Spain or western Canada for a vacation xD or le south de Francé
  • What's your body temperature?

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    JenniferJ
    @Corngold, I find the most accurate reading is a rectal reading. Compared to orally and axillary, my temp is at least 1° higher when taken rectally. When the temp is low in comparison to how warm one feels, it’s likely due to adrenaline compensating for poor thyroid function by keeping the core temp up. Often, one or more of the extremities (feet, hands, nose and ears) will be cooler as adrenaline cuts off circulation to them to keep vital organs warm. One way to tell is by taking the temp about 20–30 minutes after eating. If running on adrenaline, the temp will, in most cases, be lower.
  • Rhonda Patrick - deep dive into coffee

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    IsmailI
    @yerrag 100%! Similar to what alot of the keto and carnivore ones thought about reducing/eliminating carbs, and later on realised their mistake(s) (e.g. Thomas Delauer, Mercola, Paul Saladino etc.), though I'm still waiting for Eric Berg to come to that realisation too
  • any good canned oyster brands other than crown prince?

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    @16characterstwas have not tried either yet
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    JenniferJ
    @Mulloch94 said in For those of you FGF21maxxing or otherwise eating low protein, what are you eating?: I'm interested in hearing what all you are eating right now? I didn’t think my diet was low protein, but I average the same amount as you and get upwards of 3,000 calories daily so I guess it is. In hopes of overcoming my dependency on thyroid supplementation, something that has been especially challenging since my mum’s passing in 2022 and my dad’s cancer diagnosis in March of 2024 (I’m his caregiver), I experimented with different protein sources and intakes last year and settled on 65 g daily, which has allowed me to maintain my muscle and bone mass. My diet consists of: CARBS (65%) • Guava juice (Namai—Amazon) • Honeydew melon (juiced) • All fruit jam (St. Dalfour)—strawberry, black raspberry, blueberry, apple & cinnamon, fig royale • Honey—Boreal, mountain, prairie, orange blossom, tupelo, wildflower, wild blueberry, wild raspberry • Sugar sweetened green tea (Gold Peak) • Chocolate (Tony’s Chocolonely white chocolate) • Coconut water (Taste Nirvana) FATS (25%) • Butterfat • Cocoa butter • Coconut fat • Egg yolks PROTEINS (10%) • Beef teriyaki and hot dogs (Force of Nature) • Bone broth (Roli Roti Butcher’s) • Pastured chicken • Pastured eggs (NestFresh) • Raw 100% grass-fed A2 dairy (Benedikt Dairy NH) • Skyr (Icelandic Provisions whole milk) • Sea scallops • Skipjack tuna MISCELLANEOUS • Dried shiitake mushrooms • Garlic • Ginger • Kaffir lime leaves • Lemon grass • Rainbow carrots • Vidalia onions • Coconut aminos (Coconut Secret) • Dijon mustard (Raye’s Mustard) • Fish sauce (Red Boat 40°N) • Worcestershire sauce (Lea & Perrins) • Bay leaf (Simply Organic) • Ceylon cinnamon (Simply Organic) • Dill (Simply Organic) • Peppercorn medley (Simply Organic) • Sage (Simply Organic) • Salt (Morton’s pickling) • Tarragon (Simply Organic) • Thyme (Simply Organic • Vanilla bean powder (Bakto Flavors)