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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    660 Topics
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    LucHL
    @Mossy said in Bile can serve as a reservoir for funghi, making them harder to treat: you obviously don't think the vitamin A from liver is enough or effective in the same manner as supplementing vitamin A? No. Whenever I can eat 2 chicken livers (broth) it's fine. Not always available. No need to supplement if I eat liver. Apart case: Infection, higher ratio and more D3.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    alfredoolivasA
    I call this Illuminatione, not dropspirenone [image: 1776734580390-96ac4c93-20b6-4a3c-b8a1-542411766669-image.png]
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    393 Topics
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    engineerE
    The connection between dopamine and serotonin https://haidut.me/?p=2830 It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa. Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD) Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS) Blocking serotonin may treat obsessive-compulsive disorder (OCD) Drop in dopamine behind giving up And it goes on and on and on! https://haidut.me/?s=serotonin Looks like maybe microdosing a DA could be the way to go? Edit: Looks like the weird side effects from DAs are truly just a stress response? https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/
  • Recipes, food, meal prep, brands. Discuss them all here.

    236 Topics
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    MossyM
    @Jennifer Good news that you're getting away from the computer.  I've been doing the same. I don't believe I can change the title, but if I could, I promise I would, to put the burden, so to speak, on me, rather than you.  Though, I think the evidence will show your inclination to cooking is more natural than mine. Ok, so your brother likes attention to detail as well.  I think that makes sense.  Guys can have a more analytical approach, and girls more intuitive.  Though, that can vary, I think, depending on the task.  For me, cooking these days is more work than fun.  So, I think my desire to be precise is so I can be efficient with my time and move on to another task, or even better, free time.  Though, with my precision, I do want to get it right, so the finished dish tastes as it should. Indeed, that is trying, to say the least — serious trauma.  I'm glad you're able to move forward and that you've gotten thyroid to work for you.  It was an eye opener for me, to learn that supporting the physiological can help deal with the psychological.  I tended to approach everything as mind over matter.  Where sometimes supporting the matter can help the mind.  If thyroid works for you, I see that as a win. I must say, I would've coveted your red floaties over the blue.  At least as a younger child.  My story is very similar, coincidentally, where I was crying to have the red cup my brother had, and I had the blue.  Ok, now that I can relate to...floating in the water and relaxing, versus trying to conquer the wave. I think if there is one activity that is anti-internet age, it is floating.  The saying these days is to "touch grass", to all of us who are online too much...maybe we can add to that, "go float", "touch water", etc. That is tough, new meals on demand.  I've trained my dad to know he won't get that every night.  Most nights are a mix of premade and new ingredients.  Like I may have premade seasoned beef and rice, which I'll use in a just-made burrito or taco.  So, your dad's appetite is low to the point that only fresh food appeals to him?  Or, is he purposely being ornery? I think you'd have a good chance if The Peat is Right or Wheel of Alternative Medicine ever becomes a game show. Interesting about sprouted grains being sweeter.  Maybe there is something to that.  Where a riper version of something is usually sweeter...maybe the same for sprouted grains.  You had me at Wonka .  Wonka anything has got to be better.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @hawk1 Yeah I don't think you understood the article, if you are looking at these sources.
  • Baldness explained - Forgotten article from 15 years ago

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    @Rah1woot yes, I agree
  • What brought back my morning wood

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    lobotomizeL
    @gg12 I don’t know, I may have had a good effect on my morning wood when turning the Wi-Fi off in the house, but I don’t remember if this perceived effect happened on the same day i turned the wifi off.
  • Make Carrier Oils MCT again

    testosterone hormones
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    jamezb46J
    @CrumblingCookie Those are interesting ideas for modifying tocopherol, but you'll have to do safety studies before anyone wants to inject it and those cost a lot more than $35,000
  • eggshell membrane instead of beef/pork/fish collagen

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    @davisjedwards theres not really an easy way to do it at home. the companies that do it have some bulk process for seperating the membrane from the shell. youre probably getting some membrane with your eggshell unless youre peeling it out. the dose is really low tho.
  • Cacao/Cacao Powder

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    @alfredoolivas altereco doesn't either
  • Experiments with transdermal hormones

    Moved testosterone transdermal trt hormones
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    @alfredoolivas I think he ordered dht raws before they went out of stock, and I get good results from his dht liquid. that's all I can say, and yes my only criticism is there is no testing as some proof that it's correct dht
  • Ice Cream Evening Chat

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    @Turk That's no fun.
  • how do you justify meat eating?

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    alex155A
    I stopped eating meat (I can't digest it, because of biliary pancreatitis) now I eat red lentils, a liter of yogurt with bifid bacteria, olive oil (coconut oil gives me severe colic) I also eat apples and some berries... I mean that a vegetarian diet can be useful for some
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    @BeefEnjoyer How are you doing now? Any better? Have you managed to solve the problem or identify the culprit of your hypersalivation? Dealing with a similiar situation over here...
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    AmazoniacA
    I came across a claim that cancer hypoxia can be explained by the lack of sufficient carbon dioxide production, invoking the Bohr effect for this. Carbon dioxide helps in oxygen offloading from hemoglobin, but it's not an imperative factor. It would have been more appropriate to argue in terms of uncontrolled and fast growth outpacing the ability to properly vascularize the mass, leading to poor oxygenation. Cancer cells can produce substantial amounts of carbon dioxide with the aid of cytosolic carbonic anhydrases. Suppose that the external carbonic anhydrases (↓CO₂) overwhelm the internal ones (↑CO₂), to the point of depleting carbon dioxide. However, the effect of carbon dioxide on hemoglobin is primarily mediated by acidity from carbonic acid deprotonation.* Tumors will form plenty of carbonic acid and tend to have the surroundings extraordinarily acidic, so it remains possible that this acidity reaches hemoglobin, which circulates in blood rich in hydrocarbonate ions. Carbon dioxide is just one of the factors affecting the oxygen-hemoglobin association. Not surprisingly, acidity, temperature, and glycerate-2,3-bisphosphate also influence its behavior. In tumor thermography, they take advantage of overactive cancerous tissues being warmer than healthy ones. *The erythrocyte The oxygen affinity of Hb is influenced by H+ in a manner termed the Bohr effect. In capillaries of metabolizing tissues, CO2 enters RBCs where it is rapidly converted to H2CO3 by carbonic anhydrase (carbonate dehydratase). This carbonic acid spontaneously ionizes to H+ and HCO3−. The increased H+ concentration decreases the oxygen affinity of Hb and facilitates oxygen delivery to the tissues. The direct binding of CO2 to Hb in carbamino groups also lowers oxygen affinity, but this effect is considered to be minor. [image: 1746835363277-a19a58cc-80c7-4be0-b3b8-fd7de969f6ef-image.png]
  • What is Metabolic Uncoupling?

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    LucHL
    @pittybitty said in What is Metabolic Uncoupling?: why is metabolic uncoupling such a sought after property in the peat-sphere? From what I've understood so far: Short version: Mitochondrial uncoupling makes reference to the use of ATP, not for energy production but for “respiration” or other biological processes (thermogenesis and defense against oxidative damage: ROS). According to RP When mitochondria are “uncoupled,” they produce more carbon dioxide than normal, and the mitochondria produce fewer free radicals. Source: Protective CO2 and aging. https://raypeat2.com/articles/articles/protective-co2-aging.shtml Full explanation (to be confirmed): Uncoupling mitochondria What is the role of uncouplers in mitochondrial function and energy production? The uncoupling proteins (UCP) are transporters, present in the mitochondrial inner membrane, that mediate a regulated discharge of the proton gradient that is generated by the respiratory chain, to serve functions such as thermogenesis, maintenance of the redox balance, or reduction in the production of reactive oxygen ... (PMC2924931) Explained differently: Mitochondrial uncoupling makes reference to the use of ATP, not only for energy production but for “respiration” or other biological processes (thermogenesis and defense against oxidative damage: ROS). Source: ScienceDirect.com (PMC151194) When we partially bypass the natural process of producing energy (through the uncoupling process), we limit the production of ROS. The attenuation of ROS by partial uncoupling while maintaining sufficient ATP production would be a potential mechanism for delaying cellular senescence (Papa and Skulachev, 1997; Brand, 2000). According to RP When mitochondria are “uncoupled,” they produce more carbon dioxide than normal, and the mitochondria produce fewer free radicals. Note (LucH): CO2 is very important when trying to lower stress induced by metabolism or other "intruders". Source: Protective CO2 and aging. https://raypeat2.com/articles/articles/protective-co2-aging.shtml Natural uncouplers FFAs form one of the major class of endogenous mitochondrial uncouplers. They can act through various mechanisms. First, they stimulate directly mitochondrial respiration, as seen in intact isolated brown adipocytes or mitochondria isolated from these cells [28,29]. Capsaicins and their derivatives are red-pepper components and are long known for their capacity to induce the upregulation of uncoupling proteins, even in vivo [62]. The molecular mechanisms are still unclear but could involve sympathetic stimulation [63,64]. T3 Thyroid hormone. Among the natural endogenous molecules with uncoupling properties, one can also cite the thyroid hormone T3. T3 regulates mitochondrial uncoupling by different mechanisms: (1) by sympathetic stimulation [61], (2) by increasing acylcarnitine production [61], thereby activating mitochondrial respiration/uncoupling, and (3) by directly stimulating the transcription of the Ucp1 gene [37]. Cellular response to uncoupling It can be easily understood that the activation or induction of mitochondrial uncoupling will lead to the activation of cellular mechanisms/responses in order to cope with induced stress and/or to regulate this process. For instance, a severe mitochondrial uncoupling can lead to rapid cellular ATP depletion and, if the stress persists, to the triggering of other cellular mechanisms, such as cell death.
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    @CarbCarbCarbs I got fat as shit on all the peaty stuff like niacinamide aspirin and especially cyproheptadine. and the ice cream. oh, the ice cream...
  • Peat did not believe in the androgenic man?

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    KilgoreK
    @ThinPicking "I almost got the trans surgery. But my father wouldnt pay for it."
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    Apart from supplements, have you tried including well-tolerated green leafy vegetables, like asparagus or kale? It is often overlooked in the peat-sphere, but can be very helpful. Asparagus for example lowers excess ammonia, which often is a culprit for fatigue.
  • MRNA Vaccine Shedding - Legit?

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    daposeD
    @ThinPicking ha!!!
  • high carb zero added fat zero added protein for weight loss

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    LucHL
    The hardest part isn't losing weight, but keeping it off. Not to mention the fact that if you're a frequent yo-yo dieter, it will become increasingly difficult to lose the weight you regain as you get older. And you run the risk of your brain slowing down its metabolism (starvation protection mode). Not a good idea to get lower than 80 % of your required calorie intake. Otherwise, you will pay the bill early or late (deferred problems).
  • This topic is deleted!

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  • Is it peaty to hang out in graveyards (during the day)?

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    @ThinPicking mayhaps….
  • how would you reduce DHEA-S

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  • Tell me your opinion on the covid vaxx

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    C
    @ThinPicking somewhat but we are captive now. Animals don't breed in captivity. Isn't female birth rising too? Percent born male is decreasing. Their captivity was different for the last century. It's insane how powerful national policies and actions are for 99% of people.