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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    660 Topics
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    LucHL
    @Mossy said in Bile can serve as a reservoir for funghi, making them harder to treat: you obviously don't think the vitamin A from liver is enough or effective in the same manner as supplementing vitamin A? No. Whenever I can eat 2 chicken livers (broth) it's fine. Not always available. No need to supplement if I eat liver. Apart case: Infection, higher ratio and more D3.

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    alfredoolivasA
    I call this Illuminatione, not dropspirenone [image: 1776734580390-96ac4c93-20b6-4a3c-b8a1-542411766669-image.png]

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    393 Topics
    4k Posts
    engineerE
    The connection between dopamine and serotonin https://haidut.me/?p=2830 It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa. Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD) Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS) Blocking serotonin may treat obsessive-compulsive disorder (OCD) Drop in dopamine behind giving up And it goes on and on and on! https://haidut.me/?s=serotonin Looks like maybe microdosing a DA could be the way to go? Edit: Looks like the weird side effects from DAs are truly just a stress response? https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/

  • Recipes, food, meal prep, brands. Discuss them all here.

    236 Topics
    2k Posts
    MossyM
    @Jennifer Good news that you're getting away from the computer.  I've been doing the same. I don't believe I can change the title, but if I could, I promise I would, to put the burden, so to speak, on me, rather than you.  Though, I think the evidence will show your inclination to cooking is more natural than mine. Ok, so your brother likes attention to detail as well.  I think that makes sense.  Guys can have a more analytical approach, and girls more intuitive.  Though, that can vary, I think, depending on the task.  For me, cooking these days is more work than fun.  So, I think my desire to be precise is so I can be efficient with my time and move on to another task, or even better, free time.  Though, with my precision, I do want to get it right, so the finished dish tastes as it should. Indeed, that is trying, to say the least — serious trauma.  I'm glad you're able to move forward and that you've gotten thyroid to work for you.  It was an eye opener for me, to learn that supporting the physiological can help deal with the psychological.  I tended to approach everything as mind over matter.  Where sometimes supporting the matter can help the mind.  If thyroid works for you, I see that as a win. I must say, I would've coveted your red floaties over the blue.  At least as a younger child.  My story is very similar, coincidentally, where I was crying to have the red cup my brother had, and I had the blue.  Ok, now that I can relate to...floating in the water and relaxing, versus trying to conquer the wave. I think if there is one activity that is anti-internet age, it is floating.  The saying these days is to "touch grass", to all of us who are online too much...maybe we can add to that, "go float", "touch water", etc. That is tough, new meals on demand.  I've trained my dad to know he won't get that every night.  Most nights are a mix of premade and new ingredients.  Like I may have premade seasoned beef and rice, which I'll use in a just-made burrito or taco.  So, your dad's appetite is low to the point that only fresh food appeals to him?  Or, is he purposely being ornery? I think you'd have a good chance if The Peat is Right or Wheel of Alternative Medicine ever becomes a game show. Interesting about sprouted grains being sweeter.  Maybe there is something to that.  Where a riper version of something is usually sweeter...maybe the same for sprouted grains.  You had me at Wonka .  Wonka anything has got to be better.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    93 Topics
    1k Posts
    alfredoolivasA
    @hawk1 Yeah I don't think you understood the article, if you are looking at these sources.
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  • raytreatsR

    How to decrease puffiness in face

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    B
    methylene blue and progesterone both have this effect on my face.
  • W

    How to stop tyrosine supplement converting to Adrenaline

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    @wester130 As @alfredoolivas mentions: bright light: If i were going to be supplementing with tyrosine, I’d do so in the daytime when planning on being out and getting a good amount of light.
  • stagS

    General Adaptation Syndrome

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  • J

    Resistant starch increase endotoxin?

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    LucHL
    Endotoxins sources when eating starch? Short answer: LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life). Developed theory Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed. Endotoxins from Gut Bacteria Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…) In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free … Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”. Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach). The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.
  • C

    Body Temperature, World Temperature

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    sunsunsunS
    @Corngold go to Spain or western Canada for a vacation xD or le south de Francé
  • S

    What's your body temperature?

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    JenniferJ
    @Corngold, I find the most accurate reading is a rectal reading. Compared to orally and axillary, my temp is at least 1° higher when taken rectally. When the temp is low in comparison to how warm one feels, it’s likely due to adrenaline compensating for poor thyroid function by keeping the core temp up. Often, one or more of the extremities (feet, hands, nose and ears) will be cooler as adrenaline cuts off circulation to them to keep vital organs warm. One way to tell is by taking the temp about 20–30 minutes after eating. If running on adrenaline, the temp will, in most cases, be lower.
  • IsmailI

    Rhonda Patrick - deep dive into coffee

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    IsmailI
    @yerrag 100%! Similar to what alot of the keto and carnivore ones thought about reducing/eliminating carbs, and later on realised their mistake(s) (e.g. Thomas Delauer, Mercola, Paul Saladino etc.), though I'm still waiting for Eric Berg to come to that realisation too
  • ChudC

    any good canned oyster brands other than crown prince?

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    @16characterstwas have not tried either yet
  • M

    For those of you FGF21maxxing or otherwise eating low protein, what are you eating?

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    JenniferJ
    @Mulloch94 said in For those of you FGF21maxxing or otherwise eating low protein, what are you eating?: I'm interested in hearing what all you are eating right now? I didn’t think my diet was low protein, but I average the same amount as you and get upwards of 3,000 calories daily so I guess it is. In hopes of overcoming my dependency on thyroid supplementation, something that has been especially challenging since my mum’s passing in 2022 and my dad’s cancer diagnosis in March of 2024 (I’m his caregiver), I experimented with different protein sources and intakes last year and settled on 65 g daily, which has allowed me to maintain my muscle and bone mass, however, it took upping my fat intake from coconut sources to maintain my cycle and lower my Armour dose from 3 grains to 1. My diet consists of: CARBS (65%) • Apple cider • Bananas (extra ripe) • Figs • Guava juice (Namai—Amazon) • Honeydew melon (juiced) • Jackfruit (Pitaya Foods) • Lychee juice (Namai—Amazon) • Passion fruit juice (Namai—Amazon) • Pineapple juice (Trader Joe’s) • Pink muscat grape juice (Tamaya—Amazon) • Soursop juice (Namai—Amazon) • Watermelon (juiced) • All fruit jam (St. Dalfour)—strawberry, black raspberry, blueberry, apple & cinnamon, fig royale, French grape, mango & passion fruit, pineapple & mango • Honey—Ohi'a Lehua, orange blossom, prairie blossom, tupelo, wildflower, wild blueberry, wild raspberry • Coconut water (Symbiosis and Taste Nirvana) FATS (25%) • Coconut milk (MALK) • Coconut yogurt (Coconut Cult) • Young Thai coconut meat (Symbiosis) • Coconut butter (Artisana) • Coconut oil (365 Whole Foods and Tropical Traditions) PROTEINS (10%) • Heirloom eggs • Sea scallops • Coconut yogurt (Cocojune Greek-style) MISCELLANEOUS • Dill pickles (Bubbies) • Mung bean sprouts • Mushroom “umami” powder (Trader Joe’s) • Coconut aminos (Coconut Secret) • Instant decaf coffee (Mount Hagen) • Three mint tea (Pukka Herbs) • Lemon ginger tea (Pukka Herbs) • Vanilla bean powder (Bakto Flavors) • Ceylon cinnamon (Simply Organic) • Salt (Morton’s pickling) EXAMPLE DAY OF EATING Breakfast: Flourless banana crêpes stuffed with yogurt and jam, apple cider and sweetened (coconut) milky coffee Snack: A liter of lychee juice Lunch: Seared scallops with a mango & passion fruit teriyaki glaze, and a piña colada (coconut) milkshake Snack: A liter of guava juice Dinner: Cantonese omelette, yogurt stuffed figs with ohi’a lehua honey, “nice” cream, and sweetened milky coffee Before bed: Honey sweetened three mint tea
  • W

    how dangerous is Metyrapone - cortisol inhibitor?

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    samsonS
    @jamezb46 ya serotonin stimulates HPTA directly, thus inducing cortisol
  • J

    How to get a prescription for antibiotics ?

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    J
    thanks guys
  • B

    What was Albert Szent-Györgyi health regiment like?

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    @heyman umlauts help too
  • highseabaschH

    The Heart Remembers

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    Yeah. As does the whole organism it seems: [image: 1749591238645-477011e9-bd19-44f2-8981-8d2ba0d0485d-image.png]
  • gg12G

    coffee questions

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    LucHL
    Thanks or flowers. But before answering a question I have to asked myself if my answer could help other readers (I'm a retired teacher). If they're ready to hear what I want to say. Supposition, of course. I need to spare energy, as well, and feel it can be useful. (...) For instance, about "high level glucose". Not a bad idea for those ones who suffer from a pathology, to help the body to set things in order if ... Observe the" if". Or simply to gain energy if you metabolize glucose well, with the ability to adapt, to listen to your body... But I have no "legitimacy". So I have to cite sources and to make the balance. (...) We must also let people experiment. Some will make mistakes, including me in perception, and then they will correct their course. But be careful to keep a little energy to help the body change course. As Haidut would say: See, perceive and act! Additional info when we want to manage / moderate / adapt: Caffeine and CYP1A2 detox pathway https://bioenergetic.forum/topic/6434/caffeine-and-cyp1a2-detox-pathway => Estrogen and caffeine are both broken down in the liver by the CYP1A2 enzyme. useful info on coffee and caffeine (in French, translator needed) Caféine, ami ou ennemi ? (caffeine, friend or foe?) http://mirzoune-ciboulette.forumactif.org/t1523-cafeine-ami-ou-ennemi#17789 Coffee: Friend or foe? The answer won't be clear-cut: As is often the case, it's not all black and white. How can you optimize your situation if you enjoy drinking coffee? You have to consider the context: Coffee is an alkaloid of the methylxanthine family, present in many foods, which acts as a psychotropic stimulant (+/moderate, depending on the environment) and a mild diuretic. Alkaloids are part of the plant's defense system. But it's all in the dose (…) Imbalance (insufficient base intake) and stress management The liver's ability to convert caffeine into paraxanthine Caffeine toxicity and cytochrome P450 Habituation phenomenon and interference between adenosine and theobromine Mechanism: How does caffeine affect receptors? Caffeine therefore acts as an inhibitor. Caffeine is said to antagonize adenosine receptors and thus allow an increase in dopaminergic activity. Hormesis: Principle of hormesis "What doesn't kill us makes us stronger!" Teasing an organism, which has the capacity to recover from this stress and eliminate toxins, is good in itself. Sources and references (21x).
  • S

    36 hours into my raw milk a2 fast

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    S
    @evan-hinkle said in 36 hours into my raw milk a2 fast: s it whole milk? Peat typically recommended low fat milk. If it is full fat, do you have any history of poor fat digestion? If don’t could explain feeling low energy. Just some ideas yes its raw whole fat milk a2
  • alex155A

    familial hypercholesterolemia

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    alex155A
    @Mulloch94 Understood! Thank you)
  • M

    Tim has returned

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    M
    Another Tim vid just dropped https://www.youtube.com/watch?v=GACui0kERm8 let the record stand I agree with everything except virgin coconut oil....use the slutty stuff instead. She's a good girl that does as she's told.
  • B

    So did anyone try the D/K on the penis

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    A
    @Wabi-sabi thankfully it isn't permanent accumulation, and it does gradually start to return to baseline after stopping supplementation (same can be said for Vitamin D).
  • W

    Adolescene based cycle for heightmaxxing

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  • MauritioM

    RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman

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    MauritioM
    @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: My question is, anabologies honey diet formulation was eating one pound of ground beef a night… every night. Are you guys @ThinPicking @Mauritio calling this MR or protein restriction? That seems wrong if you are No you're right that's not protein restriction. The honey diet would fall under the category of "intermittent protein restriction". The sugar diet/ sugar fast would be real protein restriction. They're all grouped together in this video and in my response as well, because they all increase FGF21. And contrary to Jay's statement it does not take 7 days to increase FGF21 significantly, but less than 2 h. See the OP. So, the honey diet qualifies for " things that increase FGF21" since for a significant part of the day you do get the FGF21 increase. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Jay was slamming on fgf21 increasing reductive stress. Well maybe it balances out? I have a part on that in the OP. Look for "Reductive stress" and the following part on the ETC. If you read those quotes and studies it seems clear to me that FGF21 isn't a cause of reductive stress but a reaction to it. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Then Georgi chimes in later on fructose lowers phosphorus to calcium ratio, by conversion of fructose into glucose consumes phosphorus Klotho lowers phosphate. And FGF21 increases Klotho. So FGF21 lowers phosphate, thereby increasing the calcium/phosphorus ratio. Making it possible to have a decent ratio while mostly consuming fruit and sugar and little dairy. I have a post about Klotho and FGF21 on X. @dapose said in RE: The Sugar Diet/Honey Diet and FGF21: The Research (EB #133) My Response to Jay Feldman: Id be interested in hearing actual criticism of the honey diet rather than Jays knee jerk reaction. Same! I'm not saying the honey diet is the end all be all. Or that it is the perfect diet. I think it's a good diet, for some people, for a limited amount of time. It's a good tool. I'd love to hear a more nuanced criticism, because what Jay put out was quite twisted and one sided. It's like he had his conclusion first and then looked at the studies.