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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    692 Topics
    5k Posts
    C
    And I was looking for the answer on whether FMTs are a guarantor for clearance of fungal abundance in the small intestinal or colonic lumen. Surprisingly, it's a no! It appears to be even the other way round. Here's something interesting IMO about FMTs: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection, 2018 In this study, it is shown that CDI is strongly accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Post-FMT, successful responders lack their previous C. albicans dominance but rather display a high relative abundance of Saccharomyces and Aspergillus. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. In essence, therefore, annihilation of Candida dominance in CDI patients is crucial for FMT success and arguable it could be much advisable to pre-/co-treat any CDI with antifungals along with either ABx or FMT. Another study showed contrasting results of FMT on UC: Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis, 2020 Herein they showed that in contrast to FMT in CDI, clinically successful response to FMT in UC very much depended on high Candida abundance at baseline, which decreased after FMT. The authors argue that the prior Candida dominance may provide a specific niche for bacterial engraftment, ameliorating UC. So, the very opposite of the pre-conditions in CDI. However, what the authors do not talk about in their text but what their graphs clearly show is the following caveat: UC patients with a low relative Candida abundance at baseline did not only not clinically benefit from the FMT, but their dysbiosis, inflammation and Candida levels post-FMT was mostly even larger than before (confounders? Small sample size?): [image: 1-s2.0-S1931312820301700-fx1.jpg] [image: 1-s2.0-S1931312820301700-gr2.jpg]´

  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.

  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

    1k Topics
    11k Posts
    Z
    “Many people feel positive emotions in their organ nerve centers, for example the heart plexus and the solar plexus. The good feelings go with good functions. When the nerves cringe because of the presence of authoritarians, the nerve supply to the organs is impaired. Thinking of the offensive person is enough to do it. Food, activity, and feelings about your surroundings go together, and it’s important to listen to your viscera, to really participate in constructive living.” – Ray Peat The cringing of nerves blocking blood flow resulting in a stress reaction is obvious to me in the presence of some people (or a certain personality). Complete avoidance of these people is not possible and exposure therapy hasn’t worked so far. Has anyone been able to overcome this and if yes, how did you do it?

  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    395 Topics
    4k Posts
    daposeD
    I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone

  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
    2k Posts
    Milk DestroyerM
    @alfredoolivas Perhaps, but I'm not certain. I actually was eating a lot more kale recently (maybe 150g a day) for a week and I did notice I had lost some weight (like 5lbs), but I was also walking in nature more at the time. I'll try incorporating it more consistently and get back to you.

  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
    1k Posts
    alfredoolivasA
    @hawk1 okay you actually had agency & balls and settled with some pretty decent sources. It took you two months, but I’m proud of you if that means anything.
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  • P

    My Protocol for Hypothyroidism + Starch/Fat sensitivity

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    GardnerG
    @Gardner said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @sunsunsun said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @Gardner tolerance to eggs , use raw pineapple with core Not practical , everytime I want to eat egg I have to get somewhere pine apple and then juice it ... crazy No doubt it might work but , don't you get mouth ulcers (canker sore) from eating pineapple ? raw egg is very allergenic for me. Anyway, simply frying eggs (at higher temperature than boiling) deactivates most of allergens and makes them much more tolerable. Oxidized cholesterol is small amount is not a big deal
  • I

    Dr. Garrett Smith asks for help

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    LetTheRedeemedL
    Dam what does insomniac know…
  • B

    Stronger Voice From Ephedrine

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    ThinPickingT
    It may be related to this and replicable another way. https://pmc.ncbi.nlm.nih.gov/articles/PMC4958351/ https://journals.sagepub.com/doi/10.3181/00379727-24-3422 https://pubmed.ncbi.nlm.nih.gov/2039811/ https://www.jabfm.org/content/jabfp/4/4/201.full.pdf
  • H

    Health and science experts that can fill in for Dr. Ray Peat (RIP)

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    LetTheRedeemedL
    Dangit @herenow i was excited to read your comment
  • alex155A

    chicken and turkey

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  • lobotomizeL

    any explanation for photographic memory?

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    GardnerG
    John von Neumann and other Hungarian aliens from early 20th century, they just came to this world with super computer in their head. But maybe there is a role for diet too, the department where John von Neumann worked had very high sugar consumption. Mnemonic techniques work only so far, photographic memory comes naturally to some people.
  • nicemushroom17N

    Any solutions for sulfur and salicylate intolerance?

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    SmittyS
    @nicemushroom17 Molybdenum can help with sulfur clearance and glycine for salicylates. I would keep the molybdenum dose under 300mg but with glycine the world is your oyster, find whatever dose makes you feel best and keeps your skin clear. Peat disliked second and third generation antihistamines due to the presence of a Chlorine atom in their structure, which could have potential liver implications. Try 0.5mg of Cyproheptadine before bed for a few weeks and see how you feel, the drowsiness should wear off after a couple weeks.
  • stagS

    Progesterone is protective against lethal doses of histamine and endotoxin, may bind to endotoxin directly

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    stagS
    @stag While it was suspected by the authors that progesterone may bind to endotoxin directly, another mechanism of its protection may be by increasing the ability of albumin to bind LPS: One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins--it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter. Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase thc organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect. Ray Peat, From PMS to Menopause: Female Hormones in Context
  • ThyroticT

    Constipation /digestive system/stomach issues

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    LucHL
    @BioEclectic said in Constipation /digestive system/stomach issues: There's one guy with hypertension/hbp who drank about 6oz of my homemade mineral water (Cal-Mag bicarbonate) Not bad at all when you want to deal in crisis. Those persons were deficient and under stress. Note there is here a subtle balance to find. Magnesium as a laxative? Using HD magnesium as a laxative is not appropriate as a usual middle. Why? While using HD magnesium or L-acid ascorbic as an occasional middle could be effective and acceptable, by saturation (HD), it’s not advisable as a usual practice. HD: High Dose. • Not suitable for chronic constipation: Magnesium hydroxide is more appropriate for acute, occasional constipation rather than chronic, ongoing constipation. • Potential for dependency: Long-term use of laxatives, including other magnesium-based ones, can lead to a reliance on them for bowel movements, potentially making the body less responsive to natural stimuli. • Kidney problems: Individuals with kidney problems are more susceptible to the adverse effects of magnesium and may not be able to regulate magnesium levels effectively. Endpoint: Don't take more than the recommended amounts of these laxatives, or use them long-term, because they can throw off your chemistry. Combined with an underperforming kidney or heart failure, saline osmotic laxatives can be dangerous. Source: health.harvard.edu My opinion: These two middles are mechanistic osmotic ways to force the way out. Many people have tried them with success, on occasional circumstances. If the body gets accustomed to this use, natural interprandial bowel won’t come back (between 2 meals, when the bowels get empty). Make a search with “MMC and colon peristalsis” or I can develop if interested. People could get accustomed to the dose and required more substance to get the same osmotic effect. Second, we change the acid-base balance. Third, the way we proceed has an impact on the microbiota… Without mentioning the time we need (unproductive) and the stress we occasion. Short term view.
  • stagS

    Mycotoxins 101: Testing, Binders, & Detox

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  • B

    Stomach issues / digestive system problems

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    H
    @biogenic Sounds like low thyroid to me. How is your temp/pulse? Have you tried cascara sagrada, activated charcoal, carrot, antibiotics etc? That could improve things but I would look into your thyroid first.
  • rohmilchbubiR

    Eating the fighting or fleeing animal

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    rohmilchbubiR
    Vaguely related; Why we ignore the suffering of wild animals: Understanding our biases """ Executive summary: This exploratory post argues that widespread neglect of wild animal suffering—despite its immense scale—is driven by a range of cognitive biases, and that overcoming these biases requires conscious effort and intellectual honesty. Key points: Wild animal suffering vastly outweighs human-caused animal suffering, yet it is overlooked even by many animal advocates; this discrepancy is not logically grounded and is likely due to psychological biases. Cognitive biases such as status quo bias, scope neglect, survivorship bias, and compassion fade cause people to underestimate or emotionally disconnect from the scale and severity of suffering in the wild. People tend to empathize more with large, intelligent, or emotionally relatable animals, leading to the neglect of small animals (e.g., insects and crustaceans) that make up the majority of wild animal populations. Biases like omission bias and the idyllic view of nature cause individuals to excuse natural suffering or see it as less morally urgent simply because it is not human-caused. Common reasoning errors, including the assumption that “nature must be good,” false consensus about public opinion, and proportion bias, reinforce inaction by downplaying the moral importance or feasibility of interventions. The author advocates for practicing intellectual honesty and consistent reflection, arguing that only through sustained effort can we overcome our intuitive biases and make more accurate moral judgments about wild animal suffering. """
  • cs3000C

    PQQ Pyrroloquinoline quinone (found in space dust) - dietary intake

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    stagS
    @cs3000 this one is interesting too: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice We further demonstrated that bone marrow-derived macrophages (BMDMs) were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone (PQQ), reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
  • sunsunsunS

    This topic is deleted!

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  • R

    Povidone Iodine as an effective and cheap topical antifungal

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    R
    @Hearthfire It seemingly makes my curls coil a little tighter. Besides that, I haven't noticed much dramatic. Maybe a few new baby hairs.
  • raytreatsR

    How to decrease puffiness in face

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    B
    methylene blue and progesterone both have this effect on my face.
  • W

    How to stop tyrosine supplement converting to Adrenaline

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    1
    @wester130 As @alfredoolivas mentions: bright light: If i were going to be supplementing with tyrosine, I’d do so in the daytime when planning on being out and getting a good amount of light.
  • stagS

    General Adaptation Syndrome

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  • J

    Resistant starch increase endotoxin?

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    LucHL
    Endotoxins sources when eating starch? Short answer: LPS toxins don’t come from starch from itself but are the result of died gram-negative bacteria (killed by the milieu or arrived at the end of their life). Developed theory Endotoxins, specifically lipopolysaccharides (LPS) from Gram-negative bacteria, can be a concern when eating starch, but the primary source is not the starch itself. While some LPS may be present in food, including those containing starch, the major source of endotoxins in the body is from the bacteria that naturally inhabit the gut. Starch, especially resistant starch, can influence the gut microbiome and potentially impact the amount of LPS produced and absorbed. Endotoxins from Gut Bacteria Gram-negative bacteria, which are a normal part of the gut flora, have LPS in their outer membrane. When these bacteria die or their cell walls are disrupted, they release LPS into the gut. Some LPS can be absorbed into the bloodstream from the gut, potentially contributing to inflammation. (…) In essence, while starch itself isn't a direct source of endotoxins, its impact on the gut microbiome can influence the amount of endotoxins produced and absorbed, with resistant starch potentially playing a beneficial role in mitigating the effects of LPS if, and only if, there is no stagnation of the feces (optimal transit, with a functional MMC), the liver isn’t overburdened (neutralization of side-effects), the way-out is free … Note: The kind of stuff used in the 2 studies is deprived of fiber. An isolated “nutrient”. Potatoes induce a higher insulin reaction than sugar cane. When I eat 2 medium potatoes, I mix them with butter, one egg and pieces of broccoli or some frozen spinach. (+ a calcium source to neutralize the very high source of oxalates from spinach: 660 mg for 100 gr spinach). The capacity of the body is 50 mg oxalate/d. 150 - 200 mg if not every day.
  • C

    Body Temperature, World Temperature

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    sunsunsunS
    @Corngold go to Spain or western Canada for a vacation xD or le south de Francé