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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    LucHL
    @Mossy said in Bile can serve as a reservoir for funghi, making them harder to treat: you obviously don't think the vitamin A from liver is enough or effective in the same manner as supplementing vitamin A? No. Whenever I can eat 2 chicken livers (broth) it's fine. Not always available. No need to supplement if I eat liver. Apart case: Infection, higher ratio and more D3.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    alfredoolivasA
    I call this Illuminatione, not dropspirenone [image: 1776734580390-96ac4c93-20b6-4a3c-b8a1-542411766669-image.png]
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    engineerE
    The connection between dopamine and serotonin https://haidut.me/?p=2830 It just so happens that dopamine and serotonin have an inverse relationship. Each one suppressed the levels of the other. Thus, when serotonin is high dopamine is low and vice versa. That relationship extends to synthetic molecules that mimic the effects of serotonin or dopamine at the receptor level. For example serotonin agonists suppress dopamine synthesis and vice versa. Serotonin (5-HT) promotes blood vessel thickening, may cause cardiovascular disease (CVD) Serotonin (5-HT) may drive brain/liver/pancreatic and many other cancers, at the genomic level Serotonin (5-HT) increases inflammatory mediators (IL-6, NF-kB), may cause atherosclerosis SSRI drugs, serotonin (5-HT) can cause chronic fatigue syndrome (CFS) Blocking serotonin may treat obsessive-compulsive disorder (OCD) Drop in dopamine behind giving up And it goes on and on and on! https://haidut.me/?s=serotonin Looks like maybe microdosing a DA could be the way to go? Edit: Looks like the weird side effects from DAs are truly just a stress response? https://lowtoxinforum.com/threads/dopaminergic-drugs-like-bromocriptine-may-treat-alcoholilsm.11828/
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer Good news that you're getting away from the computer.  I've been doing the same. I don't believe I can change the title, but if I could, I promise I would, to put the burden, so to speak, on me, rather than you.  Though, I think the evidence will show your inclination to cooking is more natural than mine. Ok, so your brother likes attention to detail as well.  I think that makes sense.  Guys can have a more analytical approach, and girls more intuitive.  Though, that can vary, I think, depending on the task.  For me, cooking these days is more work than fun.  So, I think my desire to be precise is so I can be efficient with my time and move on to another task, or even better, free time.  Though, with my precision, I do want to get it right, so the finished dish tastes as it should. Indeed, that is trying, to say the least — serious trauma.  I'm glad you're able to move forward and that you've gotten thyroid to work for you.  It was an eye opener for me, to learn that supporting the physiological can help deal with the psychological.  I tended to approach everything as mind over matter.  Where sometimes supporting the matter can help the mind.  If thyroid works for you, I see that as a win. I must say, I would've coveted your red floaties over the blue.  At least as a younger child.  My story is very similar, coincidentally, where I was crying to have the red cup my brother had, and I had the blue.  Ok, now that I can relate to...floating in the water and relaxing, versus trying to conquer the wave. I think if there is one activity that is anti-internet age, it is floating.  The saying these days is to "touch grass", to all of us who are online too much...maybe we can add to that, "go float", "touch water", etc. That is tough, new meals on demand.  I've trained my dad to know he won't get that every night.  Most nights are a mix of premade and new ingredients.  Like I may have premade seasoned beef and rice, which I'll use in a just-made burrito or taco.  So, your dad's appetite is low to the point that only fresh food appeals to him?  Or, is he purposely being ornery? I think you'd have a good chance if The Peat is Right or Wheel of Alternative Medicine ever becomes a game show. Interesting about sprouted grains being sweeter.  Maybe there is something to that.  Where a riper version of something is usually sweeter...maybe the same for sprouted grains.  You had me at Wonka .  Wonka anything has got to be better.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @hawk1 Yeah I don't think you understood the article, if you are looking at these sources.
  • Jobs without BPAS?

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    sunsunsunS
    @alfredoolivas are you on vacation?
  • Missing small details

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    lobotomizeL
    solution was: I realized i was still doing stuff which kept my acetylcholine too high i dont remember what it was exactly but probably too high of vit b1 dosing or something else. after i stopped the diet habit which raised my acetylcholine i aced my exams
  • Vaccines - the cause of society's dysfunction

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    C
    @ursidae said in Vaccines - the cause of society's dysfunction: It is unfortunate. I know a lot of people that only talk to chat gpt, it is their only friend and they prefer it over actual humans. I believe this is a symptom of neurodivergence that people overlook and it will make the people around them that actually love humanity feel isolated, lonely and rejected as their peers continue to choose a chatbot over human connection Possible silver lining is that the hyper-utility of ai / chats may backfire. The specificity and inhumanness may inspire real conversations. The problem may be that people need to be ready to not communicate as they do with chatbots. The spontaneity, intelligence, and experience of actual people will have to be reimagined and patiently accepted.
  • Royal Jelly increases Lifespan in both insects and rats

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    @lobotomize-me 70€ is not superexpensive?
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  • My Protocol for Hypothyroidism + Starch/Fat sensitivity

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    GardnerG
    @Gardner said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @sunsunsun said in My Protocol for Hypothyroidism + Starch/Fat sensitivity: @Gardner tolerance to eggs , use raw pineapple with core Not practical , everytime I want to eat egg I have to get somewhere pine apple and then juice it ... crazy No doubt it might work but , don't you get mouth ulcers (canker sore) from eating pineapple ? raw egg is very allergenic for me. Anyway, simply frying eggs (at higher temperature than boiling) deactivates most of allergens and makes them much more tolerable. Oxidized cholesterol is small amount is not a big deal
  • Dr. Garrett Smith asks for help

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    L
    Dam what does insomniac know…
  • Stronger Voice From Ephedrine

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    ThinPickingT
    It may be related to this and replicable another way. https://pmc.ncbi.nlm.nih.gov/articles/PMC4958351/ https://journals.sagepub.com/doi/10.3181/00379727-24-3422 https://pubmed.ncbi.nlm.nih.gov/2039811/ https://www.jabfm.org/content/jabfp/4/4/201.full.pdf
  • Health and science experts that can fill in for Dr. Ray Peat (RIP)

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    Dangit @herenow i was excited to read your comment
  • chicken and turkey

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  • any explanation for photographic memory?

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    GardnerG
    John von Neumann and other Hungarian aliens from early 20th century, they just came to this world with super computer in their head. But maybe there is a role for diet too, the department where John von Neumann worked had very high sugar consumption. Mnemonic techniques work only so far, photographic memory comes naturally to some people.
  • Any solutions for sulfur and salicylate intolerance?

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    SmittyS
    @nicemushroom17 Molybdenum can help with sulfur clearance and glycine for salicylates. I would keep the molybdenum dose under 300mg but with glycine the world is your oyster, find whatever dose makes you feel best and keeps your skin clear. Peat disliked second and third generation antihistamines due to the presence of a Chlorine atom in their structure, which could have potential liver implications. Try 0.5mg of Cyproheptadine before bed for a few weeks and see how you feel, the drowsiness should wear off after a couple weeks.
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    stagS
    @stag While it was suspected by the authors that progesterone may bind to endotoxin directly, another mechanism of its protection may be by increasing the ability of albumin to bind LPS: One of estrogen's effects is to lower the amount of albumin in the blood. Estrogen causes the liver to synthesize less albumin, partly by causing the messenger RNA to be destabilized and degraded. (Iron can have some similar effects on liver RNA.) When there isn't enough albumin in the blood, water moves from the blood into the tissues. Albumin binds oily substances, and its conformation seems to be opened when it binds them. Progesterone is known to adsorb strongly to proteins--it has been called a "cardinal adsorbant," meaning that it can bind in ways that cause the protein's adsorptive capacity to change I believe that progesterone and pregnenolone oppose estrogen in many ways, but the amazing speed with which they can cause major structural changes in the soft tissues convinces me that one of their first sites of action is the albumin molecule, causing its conformation to open in such a way that it is able to more strongly bind water molecules. This physical change in albumin would change the blood's osmotic/oncotic pressure, causing water to flow into capillaries. As the edema is reduced, oxygenation is more efficient, because the pathway for oxygen diffusion becomes shorter. Albumin has been described as a first line of defense against toxins, since it binds them until the liver is able to degrade them chemically. Progesterone, pregnenolone, and cholesterol are known to increase thc organism's resistance to a great variety of toxins. (Selye coined the name "catatoxic steroids" to describe steroids of this type.) If these steroids bind to albumin in a way that opens the protein to increase its binding capacity, that single process could explain the "catatoxic" effect, as well as the anti-edema effect. Ray Peat, From PMS to Menopause: Female Hormones in Context
  • Constipation /digestive system/stomach issues

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    LucHL
    @BioEclectic said in Constipation /digestive system/stomach issues: There's one guy with hypertension/hbp who drank about 6oz of my homemade mineral water (Cal-Mag bicarbonate) Not bad at all when you want to deal in crisis. Those persons were deficient and under stress. Note there is here a subtle balance to find. Magnesium as a laxative? Using HD magnesium as a laxative is not appropriate as a usual middle. Why? While using HD magnesium or L-acid ascorbic as an occasional middle could be effective and acceptable, by saturation (HD), it’s not advisable as a usual practice. HD: High Dose. • Not suitable for chronic constipation: Magnesium hydroxide is more appropriate for acute, occasional constipation rather than chronic, ongoing constipation. • Potential for dependency: Long-term use of laxatives, including other magnesium-based ones, can lead to a reliance on them for bowel movements, potentially making the body less responsive to natural stimuli. • Kidney problems: Individuals with kidney problems are more susceptible to the adverse effects of magnesium and may not be able to regulate magnesium levels effectively. Endpoint: Don't take more than the recommended amounts of these laxatives, or use them long-term, because they can throw off your chemistry. Combined with an underperforming kidney or heart failure, saline osmotic laxatives can be dangerous. Source: health.harvard.edu My opinion: These two middles are mechanistic osmotic ways to force the way out. Many people have tried them with success, on occasional circumstances. If the body gets accustomed to this use, natural interprandial bowel won’t come back (between 2 meals, when the bowels get empty). Make a search with “MMC and colon peristalsis” or I can develop if interested. People could get accustomed to the dose and required more substance to get the same osmotic effect. Second, we change the acid-base balance. Third, the way we proceed has an impact on the microbiota… Without mentioning the time we need (unproductive) and the stress we occasion. Short term view.
  • Mycotoxins 101: Testing, Binders, & Detox

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  • Stomach issues / digestive system problems

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    H
    @biogenic Sounds like low thyroid to me. How is your temp/pulse? Have you tried cascara sagrada, activated charcoal, carrot, antibiotics etc? That could improve things but I would look into your thyroid first.
  • Eating the fighting or fleeing animal

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    rohmilchbubiR
    Vaguely related; Why we ignore the suffering of wild animals: Understanding our biases """ Executive summary: This exploratory post argues that widespread neglect of wild animal suffering—despite its immense scale—is driven by a range of cognitive biases, and that overcoming these biases requires conscious effort and intellectual honesty. Key points: Wild animal suffering vastly outweighs human-caused animal suffering, yet it is overlooked even by many animal advocates; this discrepancy is not logically grounded and is likely due to psychological biases. Cognitive biases such as status quo bias, scope neglect, survivorship bias, and compassion fade cause people to underestimate or emotionally disconnect from the scale and severity of suffering in the wild. People tend to empathize more with large, intelligent, or emotionally relatable animals, leading to the neglect of small animals (e.g., insects and crustaceans) that make up the majority of wild animal populations. Biases like omission bias and the idyllic view of nature cause individuals to excuse natural suffering or see it as less morally urgent simply because it is not human-caused. Common reasoning errors, including the assumption that “nature must be good,” false consensus about public opinion, and proportion bias, reinforce inaction by downplaying the moral importance or feasibility of interventions. The author advocates for practicing intellectual honesty and consistent reflection, arguing that only through sustained effort can we overcome our intuitive biases and make more accurate moral judgments about wild animal suffering. """
  • PQQ Pyrroloquinoline quinone (found in space dust) - dietary intake

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    stagS
    @cs3000 this one is interesting too: Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice We further demonstrated that bone marrow-derived macrophages (BMDMs) were polarized toward an inflammatory state at 8 weeks of age and that a potent antioxidant, pyrroloquinoline quinone (PQQ), reversed BMDM metabolic reprogramming from glycolytic toward oxidative metabolism by restoring trichloroacetic acid cycle function at isocitrate dehydrogenase.
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  • Povidone Iodine as an effective and cheap topical antifungal

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    R
    @Hearthfire It seemingly makes my curls coil a little tighter. Besides that, I haven't noticed much dramatic. Maybe a few new baby hairs.