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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

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    alfredoolivasA
    Progesterone actually has amazing solubility in oils! No other solvents used. Testosterone is okay too! Hydrated is the stuff you find in the store [image: 1785369239114-49330938-d5ce-436e-a9cf-54693288c6c0-image.jpeg] https://link.springer.com/article/10.1007/s11095-005-2595-6
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    R
    @alfredoolivas agreed! You want to keep a steady flow of dhea and preg. Otherwise you can take it standalone assuming you're not taking an outrageous amount 10 times a day. Taking it for years, I never experienced suppression
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    M
    @Corngold I do both
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer Oops!  My typo caused the confusion.  I meant to type French toast, not French bread.   There is a common bread brand, like Nature's Own, that has a Brioche that is pretty good.  I just looked it up: Artesano.  I've seen that everywhere. That does make sense, the growing conditions for potatoes being key.  Where the soil, water, and sun provide the quality.  Interesting that baby potatoes are easier to digest.  I'll keep that in mind.  I do remember using Yukon gold for another recipe, and they are creamy.  I think I read they're less waxy than red potatoes, but not as starchy are russet.  I'm wondering now, if the red are too waxy, and the gold would be better, for the potato salad.  I may try them next. Wow, that dairy farm sounds like the best of both worlds: modern and traditional.  And how nice of him (to say the least) to tailor the cow's diet to address your need.  I've never heard of Louis Kervran, I'll have to look him up when I get a chance.  I've never heard of biological transmutation either.  I've lightly touched upon the subject of transmutation, in other reading, but not in the subject of health.  I remember you, and others, mentioning Brix before, which is another subject for my list. No problem, on the Vital Farms tip.  It sounds like you have the knowledge, and access, to get the best eggs where you live, let alone anything else you need.  You must keep up on all of it, with you and your dad's health needs.  I've slacked off a bit, once my health took an up turn, and my budget a down turn.  At least the timing wasn't too bad.  I would imagine the quality of food, and how animals are treated, goes hand in hand.  And I know that more care equals more cost.  Do you buy those eggs locally or are they available in stores? Yes, I was pretty shocked that I can eat bananas again.  I don't recall If I had any issues from cooked bananas, but I could guess I did.  Everything gave me trouble.  I could hardly eat anything during that time.  Ray's advice makes sense, cooking the raw starch.  And needing them to be overripe raw, as well.  Just like with plantains.  I used to love cooked plantains.  They're not native to my diet or cultural heritage, but I adopted them and ate them for a long period.  I have not had them in many years, though.  Years back I hypothesized that my heavy plantain habit may have contributed to my poor health, with all the starch, but I could guess stress caused the poor health and the plantains were proof of the poor state.  I think when you're healthy, you can basically eat like a goat.  I completely relate on the need to simplify meals.  I'm doing that everywhere I can now. That's a lot of potatoes.  You must've gotten creative eating that much.  Yes, we are more than just our bodies, though it's easy to focus the fixing of our defective systems on the mechanical, because it's the most evident and immediate.  No doubt, sometimes a mechanical fix is what's needed, and brings some relief.  I'm glad you've turned some of your focus beyond the physical.  A fit mind and spirit, I feel, is the most important.  Like the body, it has to be worked at and honed.  Which is what it sounds like your repetitive hikes, a change of perspective, helped you with. That is quite the epiphany.  I like the Biblical analogies.  I think it was King David, and some other writers in the Bible, who dealt with severe depression and burdens, who contemplated nature just as you've explained, recognizing the trees and mountains that stood before them were made by the same Creator who made their very body.  There really is relief in that.  I hope you continue to find relief and hope in that.  I feel we are brought to the end of ourselves, through our hardships, so that we might know Who made us, and that we might know our true self.  I find it interesting that you come back to your water analogy, where the idea of free flowing water gives you relief.  You're not the only one.  One of my favorite authors, C. S. Lewis, had a big draw to water, and found relief both in the idea of it, and in literally floating in it. You have the right perspective, about simply being thankful.  I know it's hard for me sometimes to maintain that under the burdens.  But whenever I get my wits about me, I do come back to that.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    I thought aspirin and/or baking soda w water is good for afterwards? Gummy bears or fruit before and during lifting, no?
  • is it possible to reduce adrenal androgens, but not testicular androgens?

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    @DKJoeAgain basically it is cushings
  • DHT E/P (5AR)

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  • Post-Viral Illness

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    @Corngold After the pneumonia yes, for about a month. The post viral illness was mostly histamine intolerance/mcas symptoms. My symptoms are still improved over a month after the doxy course.
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    My pantethine protocol these days is now: Two gelatin capsules (size 1) per day, each containing: 280mg D-pantethine (it's quite dense) 2mg P5P 3mg R5P 5mg NAM 3mg NA 2mg thiamin 20mg ascorbic acid 200mcg D-biotin 50mcg molybdenum 50mg hyaluronic acid 100mcg folate is what I also wanted to include but hadn't thought of in time
  • is oral tobacco le bad?

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    No. If you want to smoke use cigars or cigarillos with pure tobacco and if you want to use snus make sure it has tobacco
  • Has anyone tried applying Androsterone on their beard to see any growth?

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  • Estrogen Dominance and Progest E

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    @Living_thing what is large boils? So was androsterone good or not? You think its better for a male than prog. Tell me more in detail about your experience with it and what effects you had.
  • Stopped absorbing thyroxine....

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    LucHL
    @FitnessMikey said in Stopped absorbing thyroxine....: anyone know whats up with thyroxine absorbtion? still can barely raise it, something with the gut? Here is an different approach... Not based on a higher level absorption but on balance since it can improve the conversion of the reserve hormone to the active one. Please, don't reject the whole thing when one part is thought to be inadequate or even "stupid". Context 1 A forumer (FM) on bioenergetics.com is trying to get thyroxine higher because when he took some T4 (first 50 mcg, afterwards 100mcg T4) it has alleviated symptoms for the most part (usual hypo symptoms, like a lack of energy, constipation). He also took some pork thyroid to raise his ft3, he said. He thinks something impedes the conversion and is trying to find out how to deal with. Context 2 FM comments: "I do everything right, empty stomach, hour away from food, it was working and just stopped. Stopped gluten now for few days but doesn't seem anything is happening yet." When doing a thyroid panel, he found rt3 was elevated. He was advised to improve balance between T3 and T4. He doesn’t catch that when he decided to get T4 higher, the correlation between global improvement and continuous high level T4 doesn’t last. I advised him to pay attention to useful nutrients for deiodinase enzymes: “Deiodinases allow tissues to customize either enhancing or decreasing the intracellular concentration of thyroid hormone at the single-cell level and independently of plasma”. I drew his attention to the fact that we need an adequate amount of cofactors as Zn, I, Mg I. Thyroid and deiodinase function depends on supply of some trace elements. Taking T3 and T4 synthetic supplement improves metabolism only for a while if Dio3 isn’t performant. Dio3 is responsible for converting T4 to the inactive reverse T3 (rT3), and also for inactivating T3, meaning it can hinder the desired metabolic effects of thyroid hormone replacement. For other readers (remind) : T4 and T3 in Hypothyroidism: T4 is a prohormone that is converted to the active hormone T3 in the body. Importance of Deiodinases: Deiodinases are enzymes that play a crucial role in regulating thyroid hormone levels. Deiodinase 1 (Dio1) and Dio2 convert T4 to T3, while Dio3 inactivates both T4 (by converting it to rT3) and T3. Dio3's Role: Dio3 is particularly important because it can significantly reduce the amount of active T3 available for metabolic processes. If Dio3 is overactive or malfunctioning, it can lead to lower than optimal levels of T3, even with thyroid hormone replacement therapy. => So Dio3 is also useful to balance / correct an excess T4 when supplementing. Impact on Metabolism: If Dio3 is not performing its function properly, it can limit the beneficial effects of T3 supplementation on metabolism, as it may convert the administered T3 into inactive metabolites. *) Excess T4 supplement and lack of Dio3 How to improve deiodinase enzymes to correct an excess t4 supplement This can be achieved through dietary adjustments, targeted supplementation, and lifestyle modifications. Se- and Zn-rich foods Ensure adequate intake of vitamin A, vitamin E, and iodine, all of which play a role in thyroid function. Avoidance of hidden deficiencies by blood test. Iodine: Consider the fact that iodine is needed by other organs but has been stolen by thyroid. Selenium: Consider the fact that deiodinase enzymes are seleno-proteins., depending on a right amount. RDA 50 mcg is not sufficient when there is a lack of other anti-oxidants (inflammation, illness, heavy metal intox). After reloading, mind excess. Too much of a good thing is bad. Manganese: if you don’t eat nuts (30 g / 1 oz.) 2x/wk. Consider medication adjustments: some medications can interfere with thyroid function. NB: When Reverse T3 dominance lasts: Pay attention to reverse T3 levels, as increased reverse T3 can indicate impaired conversion and may require specific management strategies (professional follow-up). Useful info: Trace elements and the thyroid doi: 10.3389/fendo.2022.904889 Front Endocrinol. Excerpt: Trace elements, such as iodine and selenium (Se), are vital to human health and play an essential role in metabolism. They are also important to thyroid metabolism and function, and correlate with thyroid autoimmunity and tumors. Other minerals such as iron (Ir), lithium (Li), copper (Co), zinc (Zn), manganese (Mn), magnesium (Mg), cadmium (Cd), and molybdenum (Mo), may related to thyroid function and disease. Normal thyroid function depends on a variety of trace elements for thyroid hormone synthesis and metabolism. These trace elements interact with each other and are in a dynamic balance. Question to ChatGPT: How could I make the forum user aware that there are several possibilities for enzyme deficiencies, focusing on the conversion of T3 and T4, and avoiding excessive T4 supplementation? Note: Don't offer a complete range of nutritional and behavioral advice, but rather rely on one or two probabilities. Don't try to be thorough. Focus the research on raising awareness of the problem, with clues based on what I’ve mentioned. Thanks. ChatGPT answers To raise FitnessMikey’s awareness—without overwhelming him—your best approach is to gently reframe the problem he's trying to solve. He seems focused on boosting T4 levels because he feels better temporarily, but he hasn’t grasped that high T4 is not sustainable if conversion pathways are compromised—particularly if Dio3 is dysregulated and/or cofactors are missing. Here’s a concise, respectful way you could intervene on the forum: “Mikey, it sounds like you’re doing all the right things to optimize T4 intake—but since your symptoms improved and then regressed, and your rT3 is elevated, it might be worth stepping back to look at why conversion to T3 isn’t holding. You may already know this, but just in case: T4 is just the raw material. The real action happens when it’s converted to T3—unless too much of it is shunted into rT3. That often signals a bottleneck at the enzyme level (Dio1/Dio2), or overactivity of Dio3. Sometimes it’s not about adding more T4, but about whether your system has what it needs to use it well. Even subtle shortages in selenium or zinc—both needed for deiodinase enzymes—can throw this off. Just a thought: instead of upping T4 again, maybe test or experiment to see if those cofactor pathways are part of what’s blocking the long-term benefit.”** This message: • Validates his experience without disputing his logic. • Plants a seed that more T4 isn’t always the answer. • Points to one or two trace minerals (Se, Zn) without overloading. • Encourages him to redirect his energy to a more productive investigation (enzyme support rather than more hormone). Let me know if you’d like to adjust the tone—more technical or more casual. LucH says: Bye. I'll see later. PS: Thyroid needs minimum 10 days to adjust the levels.
  • what is causing body hair/nose hair and ear hair if not androgens?

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    @risingfire do you think the pituitary is the problem?
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  • high levels of growth hormone - what does this mean?

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  • GLA from evening primrose oil

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    @sunsunsun From ChatGPT; Too much omega-6 (even GLA) can throw off your omega-3/omega-6 ratio if you don’t balance it with omega-3s (like EPA/DHA). Some people get mild GI side effects. It's not a testosterone booster or anything dramatic like that.
  • Increasing DHT

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    @hainsloy in case you hadn’t seen, I posted some discussions about dht from “Ray Peat email exchanges” at the thread here: https://bioenergetic.forum/topic/6745/androsterone-source-in-eu
  • Metamorphosis of rpf

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    ThinPickingT
    @Living_thing said in Metamorphosis of rpf: You've not got the basics of perceive, can't think and act backwards. A shining example.
  • Homemade skincare

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    Mango butter, vitamin e, mct oil, coconut oil makes a nice body butter.
  • FDA Pushes Estrogen Therapy for Women, Requests Comment

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  • What does vit A even do

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    LucHL
    @lobotomize-me said in What does vit A even do: i havnt yet understood what it does Vitamin A exists mainly in two forms, to simplify: vitamin A = retinol. Provitamin A = carotene. Provitamin A (carotene) has its own function (for example, to protect membranes as an antioxidant), but it can also be converted into vitamin A (retinol). The conversion rate is quite low and decreases with age and context. We then speak in equivalent units. NB: 10,000 IU = 3,000 mcg Vit A. We divide the IU by 0.3 Let's simplify once more. We're only concerned with vitamin A (retinol). We mostly distinguish a role in vision, and a role in cell differentiation and growth. Not only. We talk about vitamin A1/X and the latest version is vitamin A5/X. "Vitamin A" or "retinol" are two fairly equivalent, interchangeable terms, although purists may have some nuances to add: Retinol refers to the entire molecule. As DavidPS said: https://bioenergetic.forum/topic/6850/vitamin-a5 Vitamin A5 helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions in the body. How does it happen (pathway)? Retinoic acid binds to the receptors RAR (retinoic acid receptor) and RXR (retinoid X receptor) before being activated into the active hormone. Note that vitamin D and vitamin A partly use the same transport pathway, particularly in their action on genes. They both act by binding to nuclear receptors that control gene expression, and these receptors require a common partner, the RXR (retinoid X receptor), to activate gene expression. It is also important to avoid taking a high dose of vitamin A without supplementing with vitamins K2 and D3. Best at maximum 5 000 UI or 1 500 mcg Vitamin A (and not without D3) to avoid interference with osteocalcin, a protein involved in bone formation. Take once a week. Not at the same meal (with fat). https://www.julienvenesson.fr/interaction-vitamine-a-vitamine-d
  • He Asked ChatGPT One Question… Then It Got Disturbingly Prophetic

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    daposeD
    I like asking those old magic 8 balls question about what to do and what not.
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  • How Much Protein Do Tour de France Riders Consume?

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