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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    692 Topics
    5k Posts
    C
    And I was looking for the answer on whether FMTs are a guarantor for clearance of fungal abundance in the small intestinal or colonic lumen. Surprisingly, it's a no! It appears to be even the other way round. Here's something interesting IMO about FMTs: Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection, 2018 In this study, it is shown that CDI is strongly accompanied by over-representation of Candida albicans and decreased fungal diversity, richness, and evenness. Post-FMT, successful responders lack their previous C. albicans dominance but rather display a high relative abundance of Saccharomyces and Aspergillus. High abundance of C. albicans in donor stool also correlates with reduced FMT efficacy. In essence, therefore, annihilation of Candida dominance in CDI patients is crucial for FMT success and arguable it could be much advisable to pre-/co-treat any CDI with antifungals along with either ABx or FMT. Another study showed contrasting results of FMT on UC: Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis, 2020 Herein they showed that in contrast to FMT in CDI, clinically successful response to FMT in UC very much depended on high Candida abundance at baseline, which decreased after FMT. The authors argue that the prior Candida dominance may provide a specific niche for bacterial engraftment, ameliorating UC. So, the very opposite of the pre-conditions in CDI. However, what the authors do not talk about in their text but what their graphs clearly show is the following caveat: UC patients with a low relative Candida abundance at baseline did not only not clinically benefit from the FMT, but their dysbiosis, inflammation and Candida levels post-FMT was mostly even larger than before (confounders? Small sample size?): [image: 1-s2.0-S1931312820301700-fx1.jpg] [image: 1-s2.0-S1931312820301700-gr2.jpg]´
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

    62 Topics
    703 Posts
    CiceroC
    I noticed the reprint of Nutrition for Women says "100 short articles by Ray Peat, PHD," where the old one said "92...". What did they add to it? Also, note that From PMS to Menopause is for sale on Peat's website but not Amazon, and Peat's website doesn't have Generative Energy. Weird. I wonder if Katherine gets more of the money if you order from Peat's site. I'd imagine so.
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    Z
    “Many people feel positive emotions in their organ nerve centers, for example the heart plexus and the solar plexus. The good feelings go with good functions. When the nerves cringe because of the presence of authoritarians, the nerve supply to the organs is impaired. Thinking of the offensive person is enough to do it. Food, activity, and feelings about your surroundings go together, and it’s important to listen to your viscera, to really participate in constructive living.” – Ray Peat The cringing of nerves blocking blood flow resulting in a stress reaction is obvious to me in the presence of some people (or a certain personality). Complete avoidance of these people is not possible and exposure therapy hasn’t worked so far. Has anyone been able to overcome this and if yes, how did you do it?
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

    395 Topics
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    daposeD
    I’ve been using two drops 8mg of thymoquinone of the current formulation right before bed on my tongue. Sleeping extra good. Don’t wake up at all until alarm clock except some recent thunderstorms. I replaced 4 drops of Kuinone on tongue before bed. I like the effects of Tuinone better. More calming. For black seed oil seems like if you had an extra strength oil 7.5% TQ you’d need about a teaspoon of the product and would be getting lots of Pufa and other things that aren’t thymoquinone
  • Recipes, food, meal prep, brands. Discuss them all here.

    238 Topics
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    Milk DestroyerM
    @alfredoolivas Perhaps, but I'm not certain. I actually was eating a lot more kale recently (maybe 150g a day) for a week and I did notice I had lost some weight (like 5lbs), but I was also walking in nature more at the time. I'll try incorporating it more consistently and get back to you.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

    95 Topics
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    alfredoolivasA
    @hawk1 okay you actually had agency & balls and settled with some pretty decent sources. It took you two months, but I’m proud of you if that means anything.
  • FDA Pushes Estrogen Therapy for Women, Requests Comment

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  • What does vit A even do

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    LucHL
    @lobotomize-me said in What does vit A even do: i havnt yet understood what it does Vitamin A exists mainly in two forms, to simplify: vitamin A = retinol. Provitamin A = carotene. Provitamin A (carotene) has its own function (for example, to protect membranes as an antioxidant), but it can also be converted into vitamin A (retinol). The conversion rate is quite low and decreases with age and context. We then speak in equivalent units. NB: 10,000 IU = 3,000 mcg Vit A. We divide the IU by 0.3 Let's simplify once more. We're only concerned with vitamin A (retinol). We mostly distinguish a role in vision, and a role in cell differentiation and growth. Not only. We talk about vitamin A1/X and the latest version is vitamin A5/X. "Vitamin A" or "retinol" are two fairly equivalent, interchangeable terms, although purists may have some nuances to add: Retinol refers to the entire molecule. As DavidPS said: https://bioenergetic.forum/topic/6850/vitamin-a5 Vitamin A5 helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions in the body. How does it happen (pathway)? Retinoic acid binds to the receptors RAR (retinoic acid receptor) and RXR (retinoid X receptor) before being activated into the active hormone. Note that vitamin D and vitamin A partly use the same transport pathway, particularly in their action on genes. They both act by binding to nuclear receptors that control gene expression, and these receptors require a common partner, the RXR (retinoid X receptor), to activate gene expression. It is also important to avoid taking a high dose of vitamin A without supplementing with vitamins K2 and D3. Best at maximum 5 000 UI or 1 500 mcg Vitamin A (and not without D3) to avoid interference with osteocalcin, a protein involved in bone formation. Take once a week. Not at the same meal (with fat). https://www.julienvenesson.fr/interaction-vitamine-a-vitamine-d
  • He Asked ChatGPT One Question… Then It Got Disturbingly Prophetic

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    daposeD
    I like asking those old magic 8 balls question about what to do and what not.
  • This topic is deleted!

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  • How Much Protein Do Tour de France Riders Consume?

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  • turkey neck

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    @alex155 pork neck bones are good but to me less fatty. Good in sauces.
  • Low T and Anxiety, questions about steroids

    ray peat testosterone steroids
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    lobotomizeL
    are your balls hot often or do you have a varicocele?
  • How can I heal from a sunburn?

    sunburn niacinamide aspirin redlight
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    ovenO
    @oven Be careful with aspirin once sunburned. It can be useful when taken prior to sun exposure to make you slightly less prone to burning, but afterwards hypoglycemia becomes a serious consideration. Try listening to your cravings when burnt instead of following a protocol.
  • Sugar Fasting General

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    LucHL
    @Kilgore I didn’t say to eat 5-600 K/cal. as often read in a 5.2 diet. You’ve well done to attract the attention that when starving the body you could depress the metabolism (brain and thyroid). Always listen to the body reaction and adapt if required, otherwise metabolism will slow down (spare mode). If we except people with glycemia problems, who shouldn’t follow a low-calorie diet, I said we shouldn’t eat less than 80 % of our needs, on a regular basis. Or you’ll pay it soon or later, with a lack of essential nutrients, on top of that. The problem is not to lose weight, but not to regain the lost weight and gain more on top of it as in 90% of cases. So to be clear, what I mention: a) 5 days, I advise to eat / take your usual intake. 100% Mind the breakfast / the first meal as the insulin reaction of the first meal is going to impact the rest of the day. If you eat less – no matter why – which I do not advise (no need here to lose weight), don’t eat less than 80 % of you metabolic needs (metabolism + physical expenditure). Focus then on nutrient-dense foods. b) 2 days a week (not in a row) between 1200-1600 K/cal. So usually 2 meals. Why this level and not 5-600 K/cal., as often read. Our 3 mains organs require that amount to function well (liver, hart & brain). Note: If we combine 5.2 with 16.8 – what I try when want to lose excess weight (> 23 BMI), it’s ideal to take advantage (1) NB: Most of us will have to make staples, to reload energy or to make it easier when encounting a Herxheimer reaction (detox reaction). It's also normal to stall at some point during weight loss. 2 to 3 weeks is quite common. Don't rush things, or your brain will make you pay (slow-down mode). At that moment, 8-10 days after a pause, you can exercise, but in cardio mode, not in high intensity. For instance bike, quick walk (6 – 8 Km/H) or swimming. A dynamic pace but manageable over a long distance (30 minutes). Avoid exceeding 120-140 heart rates (80% of MHR) MHR: 220 – age. For beginners, and to obtain a more accurate measurement, it is recommended to perform a supervised stress test. Sources and References The 16:8 diet, an intermittent fasting method, can potentially offer several brain-related advantages by promoting metabolic switching and autophagy, a cellular cleanup process. These mechanisms may enhance brain resistance to stress, improve cognitive function, and potentially slow down age-related cognitive decline. Counter-indication: glycemia problems and brain disturbances (emotional instability). Mark Mattson, senior investigator for the National Institute on Aging, which is part of the US National Institutes of Health (NIH), has researched the health benefits of intermittent fasting, as well as the benefits of calorie restriction. According to Mattson, there are several theories to explain why fasting works: http://fitness.mercola.com/sites/fitness/archive/2013/06/28/intermittent-fasting-health-benefits.aspx?e_cid=20130628_DNL_art_1&utm_source=dnl&utm_medium=email&utm_content=art1&utm_campaign=20130628#_edn6 Note (LucH): I don't take Dr. Mercola's advice for granted. Too biased. Not suitable for everyone. *) The Health-Promoting Effects and the Mechanism of Intermittent Fasting J Diabetes Res. 2023 doi: 10.1155/2023/4038546 Health Benefits of IF IF can trigger autophagy, a cellular process that helps remove damaged cells and promotes tissue regeneration, potentially contributing to longevity and disease prevention. Insulin sensitivity (HbA1c) Weight Loss by people with high BMI Reduced Inflammation (improving gut health and a healthy gut microbiome) Cellular Repair and Protection *) Health Benefits of Intermittent Fasting Microb Physiol 2024. https://doi.org/10.1159/000540068 There are many benefits in losing weight; boosting immunity; countering the risks of diabetes, cancer, and cardiovascular diseases; and slowing the process of ageing. IF studies in animal models suggest that the process induces longevity, improve metabolic health, and positively influences hormonal changes. IF also seems to influence inflammatory reactions, lipid metabolism, and insulin sensitivity. Other sources  CMAJ April 8, 2013 http://www.cmaj.ca/site/earlyreleases/8apr13_intermittent-fasting-the-science-of-going-without.xhtml  Prostate Cancer Prostatic Diseases 2010;13:350-5 http://www.nature.com/pcan/journal/v13/n4/full/pcan201024a.html  CMAJ March 20, 2013 http://www.cmaj.ca/content/early/2013/03/25/cmaj.109-4437  Eurekalert, Study finds routine periodic fasting is good for your health, and your heart, April 3, 2011 http://www.eurekalert.org/pub_releases/2011-04/imc-sfr033111.php  Free Radical Bio Med 2007;42:665-74 http://www.sciencedirect.com/science/article/pii/S089158490600801X  International Journal of Obesity 2011;35:714-27 http://www.nature.com/ijo/journal/v35/n5/full/ijo2010171a.html  Washington Post December 31, 2012 http://www.washingtonpost.com/national/health-science/fasting-may-protect-against-disease-some-say-it-may-even-be-good-for-the-brain/2012/12/24/6e521ee8-3588-11e2-bb9b-288a310849ee_story.html?tid=wp_ipad
  • Post nut clarity

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    lobotomizeL
    @nicemushroom17 """Ich bin mir nicht sicher, ich schaue definitiv gut in die Augen der Menschen, besonders bei Frauen, zu denen ich mich hingezogen fühle, oder ob sie ein guter Mensch sind.""" so i will recommend you try out l reuteri as it raises oxytocin similar to gazing into a partners eyes or ejaculation it. you can ferment your own dairy with it so to not need to buy it often context : l reuteuri is a bonding hormone which raises testosterone and has many benefits only downside from it is that you may become more complaint if it is paired up with high serotonin. as if you believe everyone around you loves you and you love them you may be more receptive to general requests or worse so be aware
  • why is the search function in lowtoxinforum locked behind a paywall

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    ThinPickingT
    @Hearthfire said in why is the search function in lowtoxinforum locked behind a paywall: I really do miss the Ray Peat Forum. Maybe this one could e/acc with the addition of a 'Political Talk, Alternative World Theories' category and schizoid recruitment drive.
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    lobotomizeL
    https://testonation.com/2020/06/26/the-high-acetylcholine-syndrome/
  • Coffee dries out skin and eyes, like finasteride, dutasteride and accutane

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    alex155A
    @teamfortress too many 5-ar inhibitors bro... https://pubmed.ncbi.nlm.nih.gov/11380153/ Abstract Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid and myristoleic acid, as well as other natural compounds, including alizarin and curcumin, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.
  • The Coffeine, Serotonin and Dopamine conundrum

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    It seems that... Caffeine -> Physical work (Exercise) -> Mental work ...makes the mental work much less stressful than... Caffeine -> Mental work
  • OCD, ADD, Fatigue

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    gg12G
    https://youtu.be/XSUJHKAPAdg?si=hvOc2NlX7LtlHAfU I have OCD too and I really like this guys perspective on it
  • Jobs without BPAS?

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    sunsunsunS
    @alfredoolivas are you on vacation?
  • Missing small details

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    lobotomizeL
    solution was: I realized i was still doing stuff which kept my acetylcholine too high i dont remember what it was exactly but probably too high of vit b1 dosing or something else. after i stopped the diet habit which raised my acetylcholine i aced my exams
  • Vaccines - the cause of society's dysfunction

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    @ursidae said in Vaccines - the cause of society's dysfunction: It is unfortunate. I know a lot of people that only talk to chat gpt, it is their only friend and they prefer it over actual humans. I believe this is a symptom of neurodivergence that people overlook and it will make the people around them that actually love humanity feel isolated, lonely and rejected as their peers continue to choose a chatbot over human connection Possible silver lining is that the hyper-utility of ai / chats may backfire. The specificity and inhumanness may inspire real conversations. The problem may be that people need to be ready to not communicate as they do with chatbots. The spontaneity, intelligence, and experience of actual people will have to be reimagined and patiently accepted.
  • Royal Jelly increases Lifespan in both insects and rats

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    @lobotomize-me 70€ is not superexpensive?
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