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Subcategories

  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    626 Topics
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    U
    Increased Androgens: A pilot study on male volunteers (1 g/day for 1 month) found that DCI administration was associated with a +23.4% increase in testosterone and a +13.8% increase in dehydroepiandrosterone (DHEA). Reduced Estrogens: In the same study, DCI significantly reduced estrone levels (-85.0%) and reduced estradiol levels (-14.4%). Androgen Precursors: In addition to DHEA, other androgen precursors like epiandrosterone also increased (+39%). Aromatase Inhibition: DCI is believed to act as an aromatase down-modulator (inhibitor), reducing the conversion of androgens (like testosterone) into estrogens (like estradiol and estrone). D-chiro-inositol (DCI) acts to stimulate PDHP (pyruvate dehydrogenase phosphatase), which in turn dephosphorylates and activates PDH (pyruvate dehydrogenase). Insulin Mimicry: DCI has been shown to reduce the concentration of required for full activation of PDHP, a mechanism similar to how insulin works in adipocytes
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    LucHL
    @engineer said in Too high systolic blood pressure?: Should I keep using them or or lay them off? I'd stop the whole thing for 3 days. To avoid interference with half-life molecule and a return to +/ balance. Then I'll see the the interconnection of the molecules and the lack of. If you stress, you lack magnesium bisglycinate. There is interaction between B1 B2 B3 B6 + B8iotine. No more than 20-25 B3 if niacin (histamine flush). Here no caffeine until it's fine. wait 5 days. Need carbs (glucose & fructose with fiber) when taking caffeine again. Half life is 5-6 hours for caffeine. Too much caf interfere with adenosine and serotonin afterwards. And don't take a high dose because you've already done it before and everything was alright... Need l-theanine if you're angry / disturbed / in bad temper ... + a relax technique (breath) for 3'.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    loessL
    Wow, glad you're feeling a lot better. I think I might actually be experiencing something similar and I hadn't even considered it. I packed away my UV lamp in January in preparation for a move, and shortly after that started supplementing daily 5000 IU of vitamin D in olive oil because I had gotten lab results that came back low for 25-OH vitamin D @ 30 ng/mL. It's the larksupply.co vitamin D, which is pretty much unparalleled as far as quality. I think I just simply don't tolerate oral vitamin D for whatever reason. Since I got to my new place at the beginning of February I haven't been myself at all. My sleep has been inconsistent, full of interruptions for no reason, and waking up has felt like being a vampire glued to the inside of a dark coffin. I've been super lethargic, and I'd also describe my mood and perceptual capacity as both stupid and irritable. Have also been hit with random nonsensical bouts of anxiety and fear that are way out of my norm. I've been so out of wack and dragging that I haven't bothered to get that lamp out and set it up since I got here. I thought it was remnants of the flu that knocked me down a week before I moved, but I think it is very possible that the vit D supplementation might actually be responsible for seriously messing me up since I arrived here. Cutting it out and going back to the lamp.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    LukeL
    You can try to find a good Thai Curry paste without bad ingredients like seed oils. They are available with red, yellow or green color. Sauté some vegetables in a pot (Onions, carrots, zucchini, peppers, whatever you like - if you use broccoli, better cook it in water before, otherwise it will be half raw). Add meat, white fish or shrimps. Add the curry paste and mix everything. Add coconut milk and let it simmer for five minuted or so. Serve with rice.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    alfredoolivasA
    @sunsunsun https://www.youtube.com/watch?v=7f25pFhuAaY
  • Metamorphosis of rpf

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    ThinPickingT
    @Living_thing said in Metamorphosis of rpf: You've not got the basics of perceive, can't think and act backwards. A shining example.
  • Homemade skincare

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    Mango butter, vitamin e, mct oil, coconut oil makes a nice body butter.
  • FDA Pushes Estrogen Therapy for Women, Requests Comment

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  • What does vit A even do

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    LucHL
    @lobotomize-me said in What does vit A even do: i havnt yet understood what it does Vitamin A exists mainly in two forms, to simplify: vitamin A = retinol. Provitamin A = carotene. Provitamin A (carotene) has its own function (for example, to protect membranes as an antioxidant), but it can also be converted into vitamin A (retinol). The conversion rate is quite low and decreases with age and context. We then speak in equivalent units. NB: 10,000 IU = 3,000 mcg Vit A. We divide the IU by 0.3 Let's simplify once more. We're only concerned with vitamin A (retinol). We mostly distinguish a role in vision, and a role in cell differentiation and growth. Not only. We talk about vitamin A1/X and the latest version is vitamin A5/X. "Vitamin A" or "retinol" are two fairly equivalent, interchangeable terms, although purists may have some nuances to add: Retinol refers to the entire molecule. As DavidPS said: https://bioenergetic.forum/topic/6850/vitamin-a5 Vitamin A5 helps activate something called the Retinoid X Receptor (RXR), which is like a central control panel or "master switch" for many important functions in the body. How does it happen (pathway)? Retinoic acid binds to the receptors RAR (retinoic acid receptor) and RXR (retinoid X receptor) before being activated into the active hormone. Note that vitamin D and vitamin A partly use the same transport pathway, particularly in their action on genes. They both act by binding to nuclear receptors that control gene expression, and these receptors require a common partner, the RXR (retinoid X receptor), to activate gene expression. It is also important to avoid taking a high dose of vitamin A without supplementing with vitamins K2 and D3. Best at maximum 5 000 UI or 1 500 mcg Vitamin A (and not without D3) to avoid interference with osteocalcin, a protein involved in bone formation. Take once a week. Not at the same meal (with fat). https://www.julienvenesson.fr/interaction-vitamine-a-vitamine-d
  • He Asked ChatGPT One Question… Then It Got Disturbingly Prophetic

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    daposeD
    I like asking those old magic 8 balls question about what to do and what not.
  • cutting/ starting dnp cycle/wanting any advice

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    ThyroticT
    @Mallard6146 being lean is worth it bro I’ll just deal with all problems later
  • This topic is deleted!

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  • How Much Protein Do Tour de France Riders Consume?

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  • turkey neck

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    @alex155 pork neck bones are good but to me less fatty. Good in sauces.
  • Low T and Anxiety, questions about steroids

    ray peat testosterone steroids
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    lobotomizeL
    are your balls hot often or do you have a varicocele?
  • How can I heal from a sunburn?

    sunburn niacinamide aspirin redlight
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    ovenO
    @oven Be careful with aspirin once sunburned. It can be useful when taken prior to sun exposure to make you slightly less prone to burning, but afterwards hypoglycemia becomes a serious consideration. Try listening to your cravings when burnt instead of following a protocol.
  • Sugar Fasting General

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    LucHL
    @Kilgore I didn’t say to eat 5-600 K/cal. as often read in a 5.2 diet. You’ve well done to attract the attention that when starving the body you could depress the metabolism (brain and thyroid). Always listen to the body reaction and adapt if required, otherwise metabolism will slow down (spare mode). If we except people with glycemia problems, who shouldn’t follow a low-calorie diet, I said we shouldn’t eat less than 80 % of our needs, on a regular basis. Or you’ll pay it soon or later, with a lack of essential nutrients, on top of that. The problem is not to lose weight, but not to regain the lost weight and gain more on top of it as in 90% of cases. So to be clear, what I mention: a) 5 days, I advise to eat / take your usual intake. 100% Mind the breakfast / the first meal as the insulin reaction of the first meal is going to impact the rest of the day. If you eat less – no matter why – which I do not advise (no need here to lose weight), don’t eat less than 80 % of you metabolic needs (metabolism + physical expenditure). Focus then on nutrient-dense foods. b) 2 days a week (not in a row) between 1200-1600 K/cal. So usually 2 meals. Why this level and not 5-600 K/cal., as often read. Our 3 mains organs require that amount to function well (liver, hart & brain). Note: If we combine 5.2 with 16.8 – what I try when want to lose excess weight (> 23 BMI), it’s ideal to take advantage (1) NB: Most of us will have to make staples, to reload energy or to make it easier when encounting a Herxheimer reaction (detox reaction). It's also normal to stall at some point during weight loss. 2 to 3 weeks is quite common. Don't rush things, or your brain will make you pay (slow-down mode). At that moment, 8-10 days after a pause, you can exercise, but in cardio mode, not in high intensity. For instance bike, quick walk (6 – 8 Km/H) or swimming. A dynamic pace but manageable over a long distance (30 minutes). Avoid exceeding 120-140 heart rates (80% of MHR) MHR: 220 – age. For beginners, and to obtain a more accurate measurement, it is recommended to perform a supervised stress test. Sources and References The 16:8 diet, an intermittent fasting method, can potentially offer several brain-related advantages by promoting metabolic switching and autophagy, a cellular cleanup process. These mechanisms may enhance brain resistance to stress, improve cognitive function, and potentially slow down age-related cognitive decline. Counter-indication: glycemia problems and brain disturbances (emotional instability). Mark Mattson, senior investigator for the National Institute on Aging, which is part of the US National Institutes of Health (NIH), has researched the health benefits of intermittent fasting, as well as the benefits of calorie restriction. According to Mattson, there are several theories to explain why fasting works: http://fitness.mercola.com/sites/fitness/archive/2013/06/28/intermittent-fasting-health-benefits.aspx?e_cid=20130628_DNL_art_1&utm_source=dnl&utm_medium=email&utm_content=art1&utm_campaign=20130628#_edn6 Note (LucH): I don't take Dr. Mercola's advice for granted. Too biased. Not suitable for everyone. *) The Health-Promoting Effects and the Mechanism of Intermittent Fasting J Diabetes Res. 2023 doi: 10.1155/2023/4038546 Health Benefits of IF IF can trigger autophagy, a cellular process that helps remove damaged cells and promotes tissue regeneration, potentially contributing to longevity and disease prevention. Insulin sensitivity (HbA1c) Weight Loss by people with high BMI Reduced Inflammation (improving gut health and a healthy gut microbiome) Cellular Repair and Protection *) Health Benefits of Intermittent Fasting Microb Physiol 2024. https://doi.org/10.1159/000540068 There are many benefits in losing weight; boosting immunity; countering the risks of diabetes, cancer, and cardiovascular diseases; and slowing the process of ageing. IF studies in animal models suggest that the process induces longevity, improve metabolic health, and positively influences hormonal changes. IF also seems to influence inflammatory reactions, lipid metabolism, and insulin sensitivity. Other sources  CMAJ April 8, 2013 http://www.cmaj.ca/site/earlyreleases/8apr13_intermittent-fasting-the-science-of-going-without.xhtml  Prostate Cancer Prostatic Diseases 2010;13:350-5 http://www.nature.com/pcan/journal/v13/n4/full/pcan201024a.html  CMAJ March 20, 2013 http://www.cmaj.ca/content/early/2013/03/25/cmaj.109-4437  Eurekalert, Study finds routine periodic fasting is good for your health, and your heart, April 3, 2011 http://www.eurekalert.org/pub_releases/2011-04/imc-sfr033111.php  Free Radical Bio Med 2007;42:665-74 http://www.sciencedirect.com/science/article/pii/S089158490600801X  International Journal of Obesity 2011;35:714-27 http://www.nature.com/ijo/journal/v35/n5/full/ijo2010171a.html  Washington Post December 31, 2012 http://www.washingtonpost.com/national/health-science/fasting-may-protect-against-disease-some-say-it-may-even-be-good-for-the-brain/2012/12/24/6e521ee8-3588-11e2-bb9b-288a310849ee_story.html?tid=wp_ipad
  • Post nut clarity

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    lobotomizeL
    @nicemushroom17 """Ich bin mir nicht sicher, ich schaue definitiv gut in die Augen der Menschen, besonders bei Frauen, zu denen ich mich hingezogen fühle, oder ob sie ein guter Mensch sind.""" so i will recommend you try out l reuteri as it raises oxytocin similar to gazing into a partners eyes or ejaculation it. you can ferment your own dairy with it so to not need to buy it often context : l reuteuri is a bonding hormone which raises testosterone and has many benefits only downside from it is that you may become more complaint if it is paired up with high serotonin. as if you believe everyone around you loves you and you love them you may be more receptive to general requests or worse so be aware
  • why is the search function in lowtoxinforum locked behind a paywall

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    ThinPickingT
    @Hearthfire said in why is the search function in lowtoxinforum locked behind a paywall: I really do miss the Ray Peat Forum. Maybe this one could e/acc with the addition of a 'Political Talk, Alternative World Theories' category and schizoid recruitment drive.
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    lobotomizeL
    https://testonation.com/2020/06/26/the-high-acetylcholine-syndrome/
  • Coffee dries out skin and eyes, like finasteride, dutasteride and accutane

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    alex155A
    @teamfortress too many 5-ar inhibitors bro... https://pubmed.ncbi.nlm.nih.gov/11380153/ Abstract Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid and myristoleic acid, as well as other natural compounds, including alizarin and curcumin, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.
  • The Coffeine, Serotonin and Dopamine conundrum

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    It seems that... Caffeine -> Physical work (Exercise) -> Mental work ...makes the mental work much less stressful than... Caffeine -> Mental work
  • OCD, ADD, Fatigue

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    gg12G
    https://youtu.be/XSUJHKAPAdg?si=hvOc2NlX7LtlHAfU I have OCD too and I really like this guys perspective on it
  • Jobs without BPAS?

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    sunsunsunS
    @alfredoolivas are you on vacation?
  • Missing small details

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    lobotomizeL
    solution was: I realized i was still doing stuff which kept my acetylcholine too high i dont remember what it was exactly but probably too high of vit b1 dosing or something else. after i stopped the diet habit which raised my acetylcholine i aced my exams