@wester130 said in glutamine? good or bad?:

why is gelatin so high in glutamine?

We don't use gelatin for glutamine but for collagen. Collagen is rich in glycine and proline.
Glycine is going to moderate the possible excito-toxicity of glutamate (change of glutamine into glutamate (glutamic acid) in the process of assimilation, partially).

Collagène composition: Protéine 86 – 92 %

Glycine: +/ 30 % (+5 / -9) Proline: +/ 18 % (-6) Hydroxyproline: +/ 14% (-2 / +2) Alanine: 11 % (-2 / +1) Lysine: 5 % (-1)
NB: Pour le collagène selon Ray PEAt, myprotein .com, Great lakes.

Si prise de glycine : 2 x 5 g, assimilation 20 % selon un post de Haidut.

@LucH said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?:

@Ecstatic_Hamster said in What peaty substance is closest to cannabis/CBD on mental and physical relaxation?:

CBD is not deleterious to neurons. Where did you get that idea. It helps inhibit excessive neuronal firing.

Cannabinoids reduce brain connectivity
I know several studies demonstrate beneficial effects on pain. Mercola has written a thunderous article on the benefits of medical cannabis.
I remember having heard a psychiatrist (radio interview) saying we lost partial connectivity from neurons, becoming useless. But as we only use 10 % of our capacity, problems shouldn’t arise, unless teenagers begin to regularly smoke cannabinoids. Marijuana is however safer than cocaine, but with new synthetic mix drugs, it’s another problem…
Excerpt
The study’s findings revealed significant disruptions in brain connectivity across several key networks after cannabis administration. These networks include the executive control network (ECN), salience network, hippocampal network, and limbic striatal network.
Specifically, the ECN, responsible for higher-order cognitive functions like decision-making and cognitive control, showed reduced connectivity under the influence of both THC and THC + CBD.
Source: New neuroscience research: CBD does not temper THC’s effects on brain connectivity, may enhance disruption. In PsyPost, by Eric W. Dolan July 23, 2024 in Psychopharmacology Brain > Cannabis.
https://www.psypost.org/new-neuroscience-research-cbd-does-not-temper-thcs-effects-on-brain-connectivity-may-enhance-disruption/

Thank you for posting this. It isn’t my experience and I don’t think this is much of a study. But I appreciate it. I never gave this one any credence. There are much better studies that show the opposite.

@temple-of-salt I believe the main purpose of the SFA/ ethanol mixture is that it should greatly increase topical absorption of whatever is dissolved in it. Really great for stuff like vit K where a good topical dose would end up in me cutting up several capsules and mixing them with coconut oil on my legs. The olive oil may still be preferable for topical use on more sensitive areas, or for making into diy cosmetics etc. I’m unsure if one is better than the other for oral use other than olive oil being more pleasant to squirt into your mouth.

Haidut recently wrote

That corroborates Ray’s views that one should be careful when consuming foods naturally high in 5-HT such as kiwis, dates, and (unripe) bananas.
http://haidut.me/?p=2700

Peatbot.com: The context provided suggests that there are concerns about the use of 5-HTP (5-hydroxytryptophan), which is a precursor to serotonin. It is mentioned that while 5-HTP might elevate mood, it could also have potential negative effects. These include an increased risk of breast cancer, obesity, and other adverse effects due to its role in raising serotonin levels. Excess serotonin is associated with increased estrogen, which can slow liver metabolism, suppress thyroid function, and potentially lead to obesity and cancer. Therefore, while 5-HTP is sometimes used as a natural supplement to boost serotonin, there are significant concerns about its long-term health effects.

@the-MOUSE you fattys keep coping. john pork is calling me i must attend

I have experienced the same. I started using it without any bad side effects, and I took andro on off for a couple months. After awhile worse and worse symtoms such as low libido (My sex ability was fine but my desire was near 0), anhedonia, apathy all manifested which scared me as they were strong.

It took some time but eventually I correlated this to low estrogen and I went to have my levels checked and they came back as:

estradiol: 95 (pmol/L)
testosterone: 26 (nmol/L)
free testosterone: 15(nmol/L)
SHBG: 28(nmol/L)

The estrogen is right in the middle of the reference range which was very strange. I did still feel all the symptoms but I hadn't taken the Andro for a couple of days before the test.

Aromatase Inhibitors are quite scary, I read on Excelmale forum about something called PAMD or Post AI Major Dysfunction where symtoms are basically like PSSD from finasteride or SSRIs. https://www.excelmale.com/threads/persistent-low-e2-symptoms-lasting-long-after-crash-possible-solution-or-a-little-relief.27402/

Now a couple months after I still don't feel back to how I was but I am able to function. I didn't use much Andro but on one occasion I applied roughly 20 drops to my scrotum (it is following this that much of the negative symptoms started).

@temple-of-salt

https://lowtoxinforum.com/threads/pansterone-liquid-pregnenolone-dhea-mix.7426/

personal thoughts: he has changed the formula a lot of times

I think there is a big difference with the alcohol and oil solution

It's probably his best supplement

it's effective, it shouldn;t convert to estrogen but it will in sickly people

@cs3000 said in Erosive Arthritis (Osteoarthritis not rheumatoid), ray peats article + case report in fingers using thyroid:

Thyroid + Famotadine should be effective for osteoarthritis restoration

Thiamine (B1) is also a carbonic anhydrase inhibitor. It might be useful here as well.

Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

@DkJoe2 I wonder if exogenous l-dopa would convert instead to adrenaline though? And is tyrosine use safe, it being a standalone amino-acid? I suppose it'd be a matter of individual experimentation

@leon-damjanov, it sounds like you run on stress hormones to compensate for poor thyroid function. Adrenaline raises temps and lowers TSH, giving the false impression that thyroid function is good. The biggest give away to me are cold extremities. Adrenaline cuts off circulation to extremities to keep vital organs warm when thyroid function is poor. The stress of darkness and fasting at night may be triggering adrenaline, causing your temp to be normal in the morning, while eating throughout the day lowers adrenaline, resulting in lower temps and revealing what your actual thyroid function is. Regarding weight, I’m thin, consume a lot of calories for my size and activity level, and have a history of running on adrenaline due to a weak thyroid. Ray Peat talked about people like us whose hypothyroidism often goes untreated because we aren’t overweight.

A lot of bone broth, potatoes, pot roast, cheese, sourdough bread. I essentially adopt what you would expect an English medieval peasant to consume

@mavuue

You have to go back to the time your CBC blood work began to show these poor numbers and retrace to that time to figure and out what changed in terms of sickness, a change in lifestyle etc

This way, I can hazard some guesses on why your blood work took a turn south

@Insomniac cool thx

my urine is a deep yellow and it seems structured. like, times I am stressed and peeing frequently and light coloured, it is basically like water in texture. when I am feeling good and urinating my urine shimmers and when I touch it, it doesn't feel like plain water. It is structured cellular water.

I know all this because I pee in a cup then pour it down the drain.

@Rayoshi-Pufamoto just do the food sir. maybe 1 deop of k2 mk4

@Goodman said in Why did Ray Peat change his mind on sugar:

From book "Nutrition For Women" by Ray Peat, "I have seen publicity about something called the NASA astronauts' diet, and was impressed by the large amount of refined sugar in it.

He wasn't impressed with all the research from NASA. He considered HRV (heart rate variability) a fad. But HRV is the glue of of ringcore that began with the Oura ring. But all it is is glorified old heart rate measurement technology derived and spun into a hodgepodge stew of questionable biomarkers that is more marketing than science, based on it being from NASA 'rocket science.' Dressed up additionally in the garments of AI, it should keep selling well into the age of wearables with brands like Polar, Samsung, and Apple joining in the fray.