@Chris2401 I do a sort of combination of randle cycle, peating, and raw till 4 lol. Fruit, sugar, honey, and juices all day long with one cooked protein/fat heavy meal.

Btw theres some fuckery going on with some popular supplements, one i got didnt dissolve in water (not gaba)

Things like this keep me up at night. How many kilos of powders from china have I eaten over the years? I don't even want to think about it. Horrifying

Some good info here https://www.tcoyf.com/fertility-info/

The molestation I experienced began around age 5 and went on for years. I remember in great detail what happened, what I was thinking while it was happening, but it doesn’t carry with it the energetic weight it used to. I feel nothing now when I think of it and the one who abused me. I’m not angry, resentful, distrustful of all people. I am, however, more aware of the read I get on people, sensing their energy, and I trust my instincts. I can share in detail an example if anyone thinks it would be beneficial to the discussion, but I’ve avoided being assaulted as an adult many times because I don’t write my feelings/intuition off as an unwarranted side-effect of being abused, something that happens far too often because of common beliefs, and assumptions made, about women who have suffered abuse. Jokes about women with “daddy issues” comes to mind.

My family life was and still is challenging, but that’s life. There will always be challenges in relationships, however, the difference now is how I respond to them. Now I’m honest about my feelings—for better or worse, I don’t hold back—and I’m able to let harmful relationships go. I thought for sure that I was going to take my “shameful” secret with me to my grave and would forever fear my words, associating them with death because I grew up with a mother who was suicidal and understandably she was easily triggered, but my filter broke when my spine collapsed in my late 20s and my truth came out. The physical pain of the disease and subsequent injury were unimaginable, but I know it happened for me, and for those I have helped because of it.

@mavuue Hmm i guess you could experiment with coming off. It would only take like 2 weeks max for natural thyroid function to re ignite

@BioEclectic said in Does anyone take a multivitamin? What to look for in it?:

interesting note about the B50 complex. I recall you mentioning before but i don't recall the backup detail (?) That potentially harmful?

AMPK sensor: Friend or foe?
@BioEclectic
Starting point: Too much of a good thing can become counterproductive (cancer).
BioEclectic, a forum user on bioenergetic.com, recently asked me why it was not appropriate to regularly take a complex Vitamin B50 supplement. OK if it's 2x/week or these are the RDA if taken regularly, knowing that we will then have chosen a co-enzymated form (with cofactors), without yuck ingredients. (…)
Short answer:
AMPK functions as an energy sensor in our cells. This sensor plays a key role in the balance between anabolic and catabolic programs for cellular homeostasis in response to metabolic stress.
In the case of a tumor, the cancer cell attempts to slow down oxidative metabolism and works to divert the supply of glucose for its own benefit in order to grow. The cancer cell will therefore try to down-regulate the influence of AMPK, which acts a little too much like a traffic agent to supply the different organs, instead of promoting the flow of fuel to the advantage of his own needs.
So, what the link with cancer?
Taking high dose of thiamin (B1) or pyridoxine PLP (B6) – they are just 2 examples of antioxidant – they act to moderate the AMPK sensor, to dampen the effects. Right in cure or if the dose turns round RDA but not for prolonged use.
Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial metabolism and eliminated via antioxidant systems.
Cancer cells try to moderate / neutralize anti-stress.

Full answer on my forum, with link in English and in French (translator needed).

Cancer cells are usual, at a certain age, and have to be considered “normal” if the size does not exceed a €2 coin… AMPK as a regulator of energy metabolism How much B vitamins do we need, in which proportions? How can we modulate the sensitivity of the regulation? Cancer cells divert the supply of fuel and try to avoid oxidative stress. What’s the link between B1 and cancer growth? Targeting the AMP-Activated Protein Kinase for Cancer purpose?

@Goodman
How much caffeine is too much for a pregnant woman? I'm scared this might have happened to me, although I was born normal, it could have affected my brain.

@raytreats I eliminated my chronic anger with dextrose. I am more resilient to stress than I have ever been in my adult life.

A meetup is definitely a great idea, kudos for putting this together

You'll want plenty of Vitamin E to protect from the fat you are releasing as you lose weight.

I also love theanine after workouts. It helps to reduce serotonin and estrogen.

I prefer 0.7g protein per pound of your target bodyweight.

It would help to know how heavy you are now and what you plan to do to lose the weight.

You should avoid steady-state cardio except as walking. I would do HIIT sessions on an exercise bike 3x/wk and lots of walking. Walking outside will do the most for you but in the gym you should walk at a steep incline on the treadmill to burn the most calories.

You'll want to keep your muscle until close to you weigh-in date, but high reps will push more fluid into them without boosting their metabolic rate. Stick to 1-3 reps per set.

@CrumblingCookie said in Normal body temperature is now 97.9. "it’s rarely as high as 98.6 F":

s it just PUFA? Is it an altered setpoint of carbohydrate/caloric malnutrition? Is it electromagnetic interference of physiological cellular functioning? Is it a (low-key) chronic disease state?

PUFA is one key reason. The more PUFA and the less SFA the fat being used as a substrate in fatty acid metabolism, the more likely the mitochondria is deprived of co-factors it needs to run on sugar-based mitochondrial metabolism.

Sugar metabolism becomes cytosolic and glycolytic, which produces much less energy. More lactic acid is produced and less CO2.

Less energy already makes for lower temperature. But it gets worse when the body has less available CO2. Because enough CO2.is needed in the blood to effect adequate tissue oxygenation of our cells and tissues. Without enough oxygen in the tissues, the body will keep on producing energy inefficiently by producing energy from sugar glycolytically, and become more dependent on fatty acid mitochondrial metabolism, the mitochondrial pathway throttled as it is on oxygen being limited already.

The combined capacity of the mitochondria and the cytoplasm to produce energy will be much less, and this would be reflected in lower temperatures across the board.

Last year my lungs had bronchitis and I was not getting enough oxygen from breathing. At that state, and unaware of the effect of has, I dove in my fishpond to clear some debris from the bottom. I got hypothermia from it. I was shivering a lot, and struggled to come up. My temperature has gone down to 35C in less than a minute.

@LucH Great stuff thank you.

@grymsky90210

Lol thanks. I have lost some weight. Not sure it's because of the DNP tho. I have dosed it very sporadically. Mostly just used it on cold nights to stay warm but not even sure I have even felt those effects much. I thought ethanol would enhance it's effects but hasn't been the case for me. But this was by no means a perfect experiment. Did not take it regularly and am very likely underdosing.

It would be vaginally. I think the idea is that while pregnant, the body ramps up progesterone to support pregnancy. Using vaginally is to make the body think it is already pregnant, and therefore would not have need for another implantation.

Ray Peat spoke about this in an interview.

@onliest thnaks, never heard of this, but then again I'm in Europe...I will have to mix it myself since they don't ship overseas.

@sneedful said in What to do about Orange Juice causing high histamine?:

dates dont have high oxalates, the exact info is available from studies.

I have several sources mentioning no oxalates and other "respectful" ones (4x) mentioning the contrary.
I can post if you're receptive 😉
And why : Oxalates are natural compounds found in vegetables, fruits, nuts, and grains.
This inhibiting effect is due to the binding functions of antinutrients in plants in order to protect the species: If the animals eat too much of them, the natural cycle would be stopped.

Peatbot: Yes, vitamin E has undergone significant changes over the years. Originally, vitamin E was produced using methods that resulted in a product that was thick, viscous, and often brown in color. This form of vitamin E was associated with beneficial effects, including anti-estrogenic and anti-clotting properties, and was thought to protect against the toxic effects of polyunsaturated fatty acids (PUFAs).

However, over time, the manufacturing processes for vitamin E have changed. For example, when ADM bought the old Eastman distillation products factory, they altered the methods of production, which affected the consistency and appearance of vitamin E. The newer vitamin E products became more diluted, often with soybean oil, which is highly unsaturated. This change in formulation has been linked to a reduction in the beneficial effects that were observed with the original vitamin E products.

Additionally, the perception and definition of vitamin E's role have evolved. Initially, it was recognized for its fertility-enhancing and anti-estrogenic properties, but later it was primarily marketed as an antioxidant. The changes in manufacturing and formulation have led to variations in the effectiveness and safety of vitamin E supplements, with some studies suggesting increased mortality associated with certain formulations.

Overall, the form and quality of vitamin E have shifted, and these changes have influenced its perceived health benefits and risks.

Peatbot: Yes, vitamin E is generally considered safe to take on a daily basis, especially when taken in appropriate amounts. The context suggests that about 30 to 50 milligrams per day can provide full protection. However, it's important to choose a high-quality vitamin E supplement, preferably one that contains mixed tocopherols, as these are anti-inflammatory. It's also noted that vitamin E is particularly beneficial if you are consuming polyunsaturated fatty acids (PUFAs), as it can help counteract some of their negative effects.

@LetTheRedeemed Yea ray also said that thyroid is unstable dissolved in alcohol I believe

@Jennifer said in What is your favourite substance/ supplement for reducing cortisol?:

Ice cream.

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