@monkey11
Hey bro if all else fails:
Lie face down
have fat friend belly flop on your back

It is suggested to take off pants and whitey tighties for this.

good luck OP

@Mallard6146 Interesting to see another person dealing with long covid here

I did a protocol of nicotine patches for about a month and it temporarily took away all my fatigue and PEM. The only downside is that it sadly started to give me sleep issues and insomnia so I had to stop using them. I find that either smoking cigarettes or using snus give me better results for eliminating my fatigue and not giving me as many sleep issues as the patches do.

Although everyone is different you should definitely try it and see how you feel since I see a lot of success stories coming out of nicotine use for long covid.

@Evolutionarily a good way to get any drug is to basically say you were staying out of the country and were prescribed this drug at this dose and you are seeing if you can get a refill because your date for going back to the country you got it in is a little later and you are worried to run out. then once you have it prescribed one on your file you can go to another doctor and more easily get it. this works well in countries with tele-medicine consults and doctor shortages.

minocycline is easy to get over the phone by saying you took it for acne many years ago and would like to go back on it

@Norwegian-Mugabe chvd goes south. curious.

@yerrag said in Heart failure report showing t4 solo vs t4:t3 in action for full recovery (edema too):

By the way, I have fully recovered from heart failure but thanks to the knowledge gained from the bioenergetic orientation of being immersed in a thought subculture revolving around Ray Peat's writings I am back to mybold healthy thriving self.

💪 💪 💪

So few murders back then.

@Sattva Everything you said is not peaty. Meditation is bad and for losers just like psychedelics; it shrinks your amygdala as well.

Your advice is good for people with bad metabolism who want to have even worse metabolism.

He hasn’t been Keto for years.

@pittybitty said in What helps improve executive function?:

I've generally been fine in regards to energy since supplementing B vitamins, but the low executive function remains.

Give details, please, because it's not with a B-50 multi you're going to have a game changer.
You need to read these two links to understand why you lack B6 if you're inflamed or under-immune. Sure with dysbiosis.
And to understand why you need more B1 thiamine (not HCl) if you eat carbs like most people.

Potential roles of Vit B6 in inflammation and immunity.

Preventive role of B6 against chronic diseases & downregulation of the inflammatory mediators
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633
Main ideas
• Preventive role of B6 against chronic diseases. Several diseases are mediated, at least in part, by lower inflammation, possibly through modulation of several kinases. (1)
• Vit B6 deficiency is associated with lower immune function and higher susceptibility to viral infection. (2) Megadoses do not produce additional benefits after repletion. (3-4) But elderly should benefit from cyclic supplement (with pauses and moderate amounts, aka 50 mg pyridoxamine).
• Plasma PLP levels were inversely correlated with systemic inflammation markers such as CRP. (5) Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions. (6)
• Vitamin B6 supplementation improved immune function in both human and animal studies. (7-8) It improves the immune response, causing increased antibody production, and enhances communicative interactions between cytokines and chemokines. (9-11)
• The authors of this study (0) assume that vitamin B6 is possible to suppress hyperinflammation, at least in part, through NLRP3 inflammasome inhibition, limiting virus spread and cytokine storm. Together with the notion that NLRP3 inflammasome plays a central role in chronic diseases, including CVD, diabetes, and acute viral pneumonia (12–14), the anti-inflammasome effect of vitamin B6 suggest its therapeutic role in reducing the severity of COVID-19 and its complications.
• Studies indicate that B6-vitamers can reduce superoxide radical and lipid peroxide levels induced by H2O2 in vascular endothelial cells (15). Too much sulfites (H2O2) exhaust B6 PLP.
• Pyridoxamine has anti-glycation activity and inhibits the formation of AGEs. (16)
• It was identified that high-dose vitamin B6 has a global anti-inflammatory effect on lipopolysaccharide-induced inflammation in monocyte/macrophage cells by downregulating the key broad-spectrum inflammatory mediators. (17-18)
Sources and References (in English, on the link, my forum).

See too:
English Corner – Vit B6: How much is too much?
Main ideas

Too much of a good thing is bad.

Especially bad for neuro-sensitive people.

Vitamin B6 is well documented for its role as a modulator of steroid hormones. No problem with food intake if not supplemented. Maximum RDA target is 25 mg B6. But update RDA is given at 6-12 mg. There are 6 vitamers and a way-out form through the urine. If we want a pharmacological effect, we have to take into account the form of the vitamers. The active form is B6 PLP.

And for B1 thiamin
*) ## Thiamine Deficiency - A Potential Cause of SIBO and other Gut Dysfunction?
https://mirzoune-ciboulette.forumactif.org/t1896-vit-b1-deficience-desordre-intestinal
Version complète plus complète sur ce site (Vaut le détour) : Elliot Overton – Nutrition and Functional Medicine
https://www.eonutrition.co.uk/post/thiamine-deficiency-a-major-cause-of-sibo – 01/2019
*) ## Thiamine and the Microbiome – Dr. Lonsdale
https://www.hormonesmatter.com/thiamine-microbiome/ 03/23
Excerpt:
The acquisition / bioavailability of thiamine is not only essential to the physiology of our organism and our good physical and mental condition, but thiamine is a cofactor for certain intestinal bacteria that change behavior depending on the variable availability of B1 .

@wester130 said in Natural antibiotic - Allicin, Neem and Oregano Oil,:

Would this work for SIBO?

Not enough.
As said by Kviron, we need to deal with a better metabolism or the problem won't disappear, and even worsens. You're going to kill some / a lot of bacteria with these options but not all the bacteria. The strongest ones will remain and overgrowth.
You must first get informed on how dealing with LPS when killing some bacteria (how to manage a saturated liver). Need to know how to avoid stagnation of starch in the second part of the colon (See MMC and SIBO / SIFO).
Afterwards you need to help thyroid for the right amount of energy with adapted nutrients.
And last but not the ultimate you have to balance the communication between the brain and the stomach (commensal bacteria).

Excerpt:
The lower regions of the brain responsible for coordinating the autonomic nervous system are particularly vulnerable to a deficiency of thiamine. Consequently, the metabolic derangement in these brain regions caused by deficiency produces dysfunctional autonomic outputs and misfiring, which goes on to exert detrimental effects on every bodily system – including the gastrointestinal organs.
However, the severe gut dysfunction in this context is not only caused by faulty central mechanisms in the brain, but also by tissue specific changes which occur when cells lack thiamine. The primary neurotransmitter utilized by the vagus nerve is acetylcholine. Enteric neurons also use acetylcholine to initiate peristaltic contractions necessary for proper gut motility. Thiamine is necessary for the synthesis of acetylcholine and low levels produce an acetylcholine deficit, which leads to reduced vagal tone and impaired motility in the stomach and small intestine.
In the stomach, thiamine deficiency inhibits the release of hydrochloric acid from gastric cells and leads to hypochlorydria (low stomach acid). The rate of gastric motility and emptying also grinds down to a halt, producing delayed emptying, upper GI bloating, GERD/reflux and nausea. This also reduces one’s ability to digest proteins. Due to its low pH, gastric acid is also a potent antimicrobial agent against acid-sensitive microorganisms. Hypochlorydria is considered a key risk factor for the development of bacterial overgrowth.
Source:
Dr Costantini SIBO and Thiamine Deficiency
Dr Costantini and bacterial overgrowth
SIBO, IBS, and Constipation: Unrecognized Thiamine Deficiency? – June 2020
https://www.hormonesmatter.com/sibo-ibs-constipation-thiamine-deficiency/

PS: You'll probably need to optimize bile and chlorhidric acid to optimize meat digestion if the digestion takes to long.
Bile & SIBO (in French, but with links in English)
Optimiser la bile & fluidifier le transit en cas de SIBO
https://mirzoune-ciboulette.forumactif.org/t2005-impact-de-la-bile-sur-le-microbiote-et-le-transit#29365
La prolifération bactérienne est fréquemment rencontrée chez les personnes qui souffrent de colopathie (IBS).

On twitter, @haidut mentioned using vitamin K3 as a safer version of DNP to drop some weight. (This was back around ~Mar 15 2023.)

In one of the reply streams, someone posted a link to this product:

https://www.medixlife.com/shop/vicasol-buy-online-menadione/

I am not aware of a US source. I would love to find one and give it a try.

@hwisdom Np. Lmk if you need more info.

@b1 I don't think we have the kind of data we'd like to have (or think we have) to really know whether smoking untreated tobacco leaf (organic roll-your-own) is detrimental. The major confound is all the toxic crap most commercial tobacco is laced with. Even with those toxins, there were threads at RPF with "pro-tobacco-smoking points of view" posting studies about how difficult it was to give rodents, dogs and other animal models lung cancer by exposure to tobacco smoke.

I think many of us here have unusually well-attuned bullshit detectors (especially after seeing how "pushed", exaggerated and propagandized the industry-or government-promoted vaccine-mandate studies were pushed and conflicting information was suppressed). It's easy to see pro-tobacco-smoking studies as "industry propaganda" but I now think perhaps the same players, in some cases, control both sides.

We know that nicotine patches (without smoke) provide measurable pro-metabolic gains for IBS, preventing neuro-degeneration and dementia-causing illness. So by that measure, nicotine has a pretty substantial evidence base to support it.

Five years ago, I would have thought anyone saying a good word about smoking tobacco being healthy was industry-funded propaganda or bunk. Now I'm not so sure. I think a close look at the studies reveals something surprising: how difficult it is to find persuasive open-and-shut-case evidence for harms associated with smoking. I don't think there have been any RCTs (or ever could be due to ethics-committee rules) showing that smoking dried tobacco leaves with few or no additives causes lung problems, respiratory stress or anything else harmful.

I think the jury is out on this question more than we might have thought (those of us who once thought -- wrongly, I now believe -- that there is a conclusive evidence base showing that smoking tobacco is harmful). I think if you can afford very high-end roll-your-own tobacco with minimal additives, then smoking it may in fact be net beneficial. It's so expensive however that it's probably a bad idea for most people to consider starting. How would we know until we try (e.g. eating Peaty, being metabolically and scientifically attuned, and smoking high-end organic leaf tobacco) -- maybe it's worth considering for those can afford it. Yolo.

@stag thank you so much for this, I always wanted to read this study fully, much appreciated 🙏