@the-MOUSE https://www.kmart.com.au/product/400ml-glass-container-with-silicone-lid-43376667/?sku=43376667&utm_source=google&utm_medium=organic&utm_campaign=free_listings&srsltid=AfmBOop1ktGQ1JX8eedvlRrSXY6HjAP23DZGH-veYl0GjN7SWxnJQm7uNxw&region_id=200001

Thyroid for me is essential but not the 1 pill to cure all my woes.

Without taking thyroid, my pulse dips to 36 bpm and in the 40s - 50s with office work. On thyroid, my daytime resting is around 70 bpm.

I take Cynoplus and Cynomel. I need less in the summer and more in the winter to reach a daytime temperature of 37 C or higher and a reasonable pulse.

I hope that one day I can become metabolically healthy enough to stop needing it, but until then, I still have to source it.

@BioEclectic said in Never feel satiated:

Pressure cookers actually save energy

Effect of high pressure steam on the eating quality of meat proteins
High-pressure processing has potential for food preservation purposes because it can inactivate microorganisms and enzymes.
The spatial configuration of some enzymes is changed. Proteins are composed of amino acids connected by amide bonds. Due to high reactivity under pressure and heat the molecules are twisted and changed. They could be no longer recognized by our digestive enzymes.

The use of high pressure to modify the functionality of food proteins
https://doi.org/10.1016/S0924-2244(97)01015-7
However some studies have shown to make it easier to digest meat but high pressure can affect protein conformation and can lead to protein denaturation, aggregation or gelation, depending on the protein system, the applied pressure, the temperature and the duration of the pressure treatment.

@GreekDemiGod Jay Feldman and Mike fave recommend a good amount of protein for clients around .6 to .8 grams per pound with a good source of glycine. It’s reasonable to me

I wanna know what Dinkov thinks about this.

"It seems that an "empty/unbound androgen receptor" is the worst thing as far as glucocorticoid signalling - and that even androgen antagonists interacting with the androgen receptor can reduce that glucocorticoid signalling."
https://raypeatforum.com/community/threads/panquinone-liquid-triquinoyl-quinone-mix-for-lab-r-d.11566/page-8#post-292585

@LucH That's a very comprehensive paper, thanks for sharing!

I didn't mean that zonulin is a protective inhibitor, I was referencing that substances that inhibit zonulin (like Larazotide acetate) are protective against its deleterious effects (like type 1 diabetes / celiac), as elaborated on in the papers we have both posted.

@LucH said in Zonulin and its Consequences:

For me zonulin is secreted in presence of excess lectins and gliadin (agglutinin family) to avoid aggregation with L-glutamine from the membranes. Zonulin acts as a garde-barrière, telling the body to let the toxins get away. Zonulin tells the tight junctions to stay open …

Do you have more info on this? A search for lectins and leaky gut discloses this article:
Lectins: The Gluten-Lectin-Leaky Gut Connection

Some lectins that we consume in everyday foods can bind to the sugars in the cell walls of the gut or in the blood. This can cause an immune response, leading to inflammation, intestinal damage, altered gut flora, malabsorption, decreased cellular repair, cellular death, and eventually disease.

These lectins bind to glycoproteins and glycolipids (sugar-coated proteins and fats) found on the surface of human and other animal cells. This binding allows for agglutination (clumping) and sometimes can produce an immune response. They can cause agglutination of blood cells and they can bind to the cells that line the small intestine.

This article also references Fasano, he seems to be a popular guy in zonulin world. The relevant reference regarding lectins is here (I think):
Dietary lectins are metabolic signals for the gut and modulate immune and hormone functions

A related paper is here:
Characteristics and consequences of interactions of lectins with the intestinal mucosa

Following general Peat diet suggestions will have you avoiding most lectin-containing foods anyway, but there are two that stick out: dairy and nightshades. Someone could be getting most of their calories from milk and potatoes thinking theyre fine because its Peaty but may be driving intestinal permeability due to the lectin content.

The example given in the article of a noxious lectin is wheat germ agglutinin. I wonder how bad non-wheat derived lectins like those from potatoes and milk are.

If the mechanism is as described I also wonder if it may be advisable to keep dietary gluten and lectins to a minimum during L-glutamine supplementation, as that combination may provide ample reason for a zonulin trigger. This will be easy for wheat, likely also potatoes, but cutting milk may prove to be a challenge, if necessary. It also may be the case that the supraphysiological doses of glutamine generally used in supplementation may override any zonulin signaling caused by incidental dietary lectins. I'm not sure.

Lol bling became cool last second. Rip

look up cannabis hypermesis syndrome to find out what happens to some people after long term marijuana smoking.

C3G has similar activities . It's high in elderberry juice as reported in this thread.
(https://bioenergetic.forum/topic/847/cyanidin-3-o-glucoside-c3g-the-next-polyphenolic-star?_=1724528336146)

And elderberry juice is traditionally given when you have the flue in Germany.

There's also some study showing anti-viral effects specifically in Covid.

https://pubmed.ncbi.nlm.nih.gov/35807916/

https://pubmed.ncbi.nlm.nih.gov/35431537/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856223/

@Cezar4911 also I got a powerful warmth that was uncomfortable, similar to high protein meal

@FOR-THE-POTATO This is off topic....

@the-MOUSE you dont really need hair once your his age and already have wife/kids. and being built like that is peaty. also 1.5 liters chocolate ice cream/day diet cures hairloss but you need to supp bicarb, sunbathe, and do nofap for it to take effect.

@Nomanarch A large amount of peaters I meet online either here or on the RPF are from Canada including me. It's interesting because I would think for our size it would be much rarer to see a Canadians on here. To answer your question though all the substances you use are good and peaty but it can be excessive if your taking them everyday. t3 and t4 are easily acquired via meds.com.mx. I had no problems getting mine through customs.

Besides that ensuring you have adequate carb intake, salt to taste, eating gelatinous foods.

Some other supplements you can think about trying in the future are Progest e, Pregnenolone, and Cyproheptadine.

@Jennifer said in Protein synthesis / net carbs:

“*Protein: (about 15-20% calories) .6-.8g/lb. Protein should be on the higher end if you are active, or you are older. Protein sources should be from ruminant meat (beef, bison, lamb, goat), specific seafood (shrimp, scallops, cod, sole, oysters, mussels, clams), pasture raised eggs, very lean 99% chicken/ turkey/ fowl (These are very lean because they are high in polyunsaturated fats if not).”

I am older and active to I try to get 1g/lb. Like I mentioned in an earlier post when I dropped the protein intake below that my recovery suffered but that was with lower carbs so now that I am increasing them I will adjust and see how it works. I only track animal based protein in crono and disregard the plant based.

@Jennifer said in Protein synthesis / net carbs:

Since you developed allergies and digestive issues following a keto(ish) elimination diet and feel better since upping your carbs, I wonder if your thyroid was affected. Have you tracked your temps and pulse rate first thing in the morning and 20–30 minutes after eating? Too much protein relative to your needs and not enough carbs can lower thyroid function, and poor thyroid function is a common cause of allergies.

I never had any thyroid problems until I did the lower carb diet. I did lab work while I was on that diet and my free T3 crashed but as soon as I increased the carbs it came right back to upper levels and that was just around 120 carbs. Definitely affected my thyroid. Unfortunately I had food allergies before starting that diet. I have had to avoid shell fish for quite some time now. But the EoE and possibly related to dairy/eggs could be the supps she has me on or my gut is now so messed up that will be need to be corrected. Would be nice if it was one of the supplements. Good thing is I am rotating off of some of the supps she has had me on for a year now and that is in the time frame EoE appeared.

Something I will need to watch, thanks.